John R. Engen
John R. Engen
James L. Waters Chair & Distinguished Professor of Chemistry, Northeastern University
Verified email at - Homepage
Cited by
Cited by
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
W Zhou, D Ercan, L Chen, CH Yun, D Li, M Capelletti, AB Cortot, ...
Nature 462 (7276), 1070-1074, 2009
Hydrogen exchange mass spectrometry for the analysis of protein dynamics
TE Wales, JR Engen
Mass spectrometry reviews 25 (1), 158-170, 2006
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
J Zhang, FJ Adrián, W Jahnke, SW Cowan-Jacob, AG Li, RE Iacob, T Sim, ...
Nature 463 (7280), 501-506, 2010
Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars
SA Berkowitz, JR Engen, JR Mazzeo, GB Jones
Nature Reviews Drug Discovery 11 (7), 527-540, 2012
Analysis of protein conformation and dynamics by hydrogen/deuterium exchange MS
JR Engen
Analytical chemistry 81 (19), 7870-7875, 2009
Post-translational modifications differentially affect IgG1 conformation and receptor binding
D Houde, Y Peng, SA Berkowitz, JR Engen
Molecular & Cellular Proteomics 9 (8), 1716-1728, 2010
The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies
D Houde, SA Berkowitz, JR Engen
Journal of pharmaceutical sciences 100 (6), 2071-2086, 2011
Therapeutic Targeting of Oncogenic K‐Ras by a Covalent Catalytic Site Inhibitor
SM Lim, KD Westover, SB Ficarro, RA Harrison, HG Choi, ME Pacold, ...
Angewandte Chemie International Edition 53 (1), 199-204, 2014
High-speed and high-resolution UPLC separation at zero degrees Celsius
TE Wales, KE Fadgen, GC Gerhardt, JR Engen
Analytical chemistry 80 (17), 6815-6820, 2008
Investigating Protein Structure and Dynamics by Hydrogen Exchange MS
JR Engen, DL Smith
Analytical chemistry 73 (9), 256-265, 2001
Semi-automated data processing of hydrogen exchange mass spectra using HX-Express
DD Weis, JR Engen, IJ Kass
Journal of the American Society for Mass Spectrometry 17 (12), 1700-1703, 2006
Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry
D Houde, J Arndt, W Domeier, S Berkowitz, JR Engen
Analytical chemistry 81 (7), 2644-2651, 2009
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
W Yu, EJ Chory, AK Wernimont, W Tempel, A Scopton, A Federation, ...
Nature Communications 3, 1288, 2012
Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis
DD Weis, TE Wales, JR Engen, M Hotchko, LF Ten Eyck
Journal of the American Society for Mass Spectrometry 17 (11), 1498-1509, 2006
Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome
Y Shi, X Chen, S Elsasser, BB Stocks, G Tian, BH Lee, Y Shi, N Zhang, ...
Science 351 (6275), aad9421, 2016
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments
GR Masson, JE Burke, NG Ahn, GS Anand, C Borchers, S Brier, ...
Nature Methods 16 (7), 595-602, 2019
Structure and dynamic regulation of Src-family kinases
JR Engen, TE Wales, JM Hochrein, MA Meyn, SB Ozkan, I Bahar, ...
Cellular and Molecular Life Sciences 65 (19), 3058-3073, 2008
Hydrogen exchange mass spectrometry: what is it and what can it tell us?
SR Marcsisin, JR Engen
Analytical and bioanalytical chemistry 397 (3), 967-972, 2010
Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications
H Wei, J Mo, L Tao, RJ Russell, AA Tymiak, G Chen, RE Iacob, JR Engen
Drug discovery today 19 (1), 95-102, 2014
Force interacts with macromolecular structure in activation of TGF-β
X Dong, B Zhao, RE Iacob, J Zhu, AC Koksal, C Lu, JR Engen, ...
Nature 542 (7639), 55-59, 2017
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