Siew Pheng Lim
Siew Pheng Lim
Singzyme Pte Ltd
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Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus
P Erbel, N Schiering, A D'Arcy, M Renatus, M Kroemer, SP Lim, Z Yin, ...
Nature structural & molecular biology 13 (4), 372-373, 2006
Ten years of dengue drug discovery: progress and prospects
SP Lim, QY Wang, CG Noble, YL Chen, H Dong, B Zou, F Yokokawa, ...
Antiviral research 100 (2), 500-519, 2013
Strategies for development of dengue virus inhibitors
CG Noble, YL Chen, H Dong, F Gu, SP Lim, W Schul, QY Wang, PY Shi
Antiviral research 85 (3), 450-462, 2010
Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein
D Luo, T Xu, RP Watson, D Scherer‐Becker, A Sampath, W Jahnke, ...
The EMBO journal 27 (23), 3209-3219, 2008
Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries
J Li, SP Lim, D Beer, V Patel, D Wen, C Tumanut, DC Tully, JA Williams, ...
Journal of Biological Chemistry 280 (31), 28766-28774, 2005
Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target
J Lescar, D Luo, T Xu, A Sampath, SP Lim, B Canard, SG Vasudevan
Antiviral research 80 (2), 94-101, 2008
The dengue virus NS5 protein as a target for drug discovery
SP Lim, CG Noble, PY Shi
Antiviral research 119, 57-67, 2015
A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication
Y Zhao, TS Soh, J Zheng, KWK Chan, WW Phoo, CC Lee, MYF Tay, ...
PLoS pathogens 11 (3), e1004682, 2015
Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead
Z Yin, SJ Patel, WL Wang, G Wang, WL Chan, KRR Rao, J Alam, ...
Bioorganic & medicinal chemistry letters 16 (1), 36-39, 2006
Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor
WT Sing, CL Lee, SL Yeo, SP Lim, MM Sim
Bioorganic & Medicinal Chemistry Letters 11 (2), 91-94, 2001
Small molecule inhibitors that selectively block dengue virus methyltransferase
SP Lim, LS Sonntag, C Noble, SH Nilar, RH Ng, G Zou, P Monaghan, ...
Journal of Biological Chemistry 286 (8), 6233-6240, 2011
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors
Z Yin, SJ Patel, WL Wang, WL Chan, KRR Rao, G Wang, X Ngew, V Patel, ...
Bioorganic & medicinal chemistry letters 16 (1), 40-43, 2006
2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase
H Dong, DC Chang, MHC Hua, SP Lim, YH Chionh, F Hia, YH Lee, ...
PLoS pathogens 8 (4), e1002642, 2012
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.
YF Lim S.P., Noble C.G., Seh C.C., Soh T.S., El Sahili A., Chan G.K., Lescar ...
PLOS Pathogens 12 (8), e1005737, 2016
Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication
PY Goh, YJ Tan, SP Lim, YH Tan, SG Lim, F Fuller-Pace, W Hong
Journal of virology 78 (10), 5288-5298, 2004
Flavivirus RNA methylation
H Dong, K Fink, R Züst, SP Lim, CF Qin, PY Shi
Journal of General Virology 95 (4), 763-778, 2014
The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell …
SP Lim, A Garzino-Demo
Journal of virology 74 (4), 1632-1640, 2000
Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing
CY Ng, F Gu, WY Phong, YL Chen, SP Lim, A Davidson, SG Vasudevan
Antiviral research 76 (3), 222-231, 2007
A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease
C Bodenreider, D Beer, TH Keller, S Sonntag, D Wen, LJ Yap, YH Yau, ...
Analytical biochemistry 395 (2), 195-204, 2009
Biochemical and genetic characterization of dengue virus methyltransferase
H Dong, DC Chang, X Xie, YX Toh, KY Chung, G Zou, J Lescar, SP Lim, ...
Virology 405 (2), 568-578, 2010
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