| Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus P Erbel, N Schiering, A D'Arcy, M Renatus, M Kroemer, SP Lim, Z Yin, ... Nature structural & molecular biology 13 (4), 372-373, 2006 | 585 | 2006 |
| Ten years of dengue drug discovery: progress and prospects SP Lim, QY Wang, CG Noble, YL Chen, H Dong, B Zou, F Yokokawa, ... Antiviral research 100 (2), 500-519, 2013 | 368 | 2013 |
| Strategies for development of dengue virus inhibitors CG Noble, YL Chen, H Dong, F Gu, SP Lim, W Schul, QY Wang, PY Shi Antiviral research 85 (3), 450-462, 2010 | 308 | 2010 |
| Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries J Li, SP Lim, D Beer, V Patel, D Wen, C Tumanut, DC Tully, JA Williams, ... Journal of Biological Chemistry 280 (31), 28766-28774, 2005 | 280 | 2005 |
| Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein D Luo, T Xu, RP Watson, D Scherer‐Becker, A Sampath, W Jahnke, ... The EMBO journal 27 (23), 3209-3219, 2008 | 272 | 2008 |
| Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target J Lescar, D Luo, T Xu, A Sampath, SP Lim, B Canard, SG Vasudevan Antiviral research 80 (2), 94-101, 2008 | 248 | 2008 |
| Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor WT Sing, CL Lee, SL Yeo, SP Lim, MM Sim Bioorganic & medicinal chemistry letters 11 (2), 91-94, 2001 | 197 | 2001 |
| Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead Z Yin, SJ Patel, WL Wang, G Wang, WL Chan, KRR Rao, J Alam, ... Bioorganic & medicinal chemistry letters 16 (1), 36-39, 2006 | 196 | 2006 |
| A crystal structure of the dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication Y Zhao, TS Soh, J Zheng, KWK Chan, WW Phoo, CC Lee, MYF Tay, ... PLoS pathogens 11 (3), e1004682, 2015 | 194 | 2015 |
| The dengue virus NS5 protein as a target for drug discovery SP Lim, CG Noble, PY Shi Antiviral research 119, 57-67, 2015 | 189 | 2015 |
| Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors Z Yin, SJ Patel, WL Wang, WL Chan, KRR Rao, G Wang, X Ngew, V Patel, ... Bioorganic & medicinal chemistry letters 16 (1), 40-43, 2006 | 174 | 2006 |
| Small molecule inhibitors that selectively block dengue virus methyltransferase SP Lim, LS Sonntag, C Noble, SH Nilar, RH Ng, G Zou, P Monaghan, ... Journal of Biological Chemistry 286 (8), 6233-6240, 2011 | 169 | 2011 |
| Cellular RNA helicase p68 relocalization and interaction with the hepatitis C virus (HCV) NS5B protein and the potential role of p68 in HCV RNA replication PY Goh, YJ Tan, SP Lim, YH Tan, SG Lim, F Fuller-Pace, W Hong Journal of virology 78 (10), 5288-5298, 2004 | 143 | 2004 |
| 2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase H Dong, DC Chang, MHC Hua, SP Lim, YH Chionh, F Hia, YH Lee, ... PLoS pathogens 8 (4), e1002642, 2012 | 142 | 2012 |
| Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling. YF Lim S.P., Noble C.G., Seh C.C., Soh T.S., El Sahili A., Chan G.K., Lescar ... PLOS Pathogens 12 (8), e1005737, 2016 | 130 | 2016 |
| Flavivirus RNA methylation H Dong, K Fink, R Züst, SP Lim, CF Qin, PY Shi Journal of General Virology 95 (4), 763-778, 2014 | 128 | 2014 |
| The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell … SP Lim, A Garzino-Demo Journal of virology 74 (4), 1632-1640, 2000 | 117 | 2000 |
| Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing CY Ng, F Gu, WY Phong, YL Chen, SP Lim, A Davidson, SG Vasudevan Antiviral research 76 (3), 222-231, 2007 | 108 | 2007 |
| A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease C Bodenreider, D Beer, TH Keller, S Sonntag, D Wen, LJ Yap, YH Yau, ... Analytical biochemistry 395 (2), 195-204, 2009 | 106 | 2009 |
| Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor CG Noble, SP Lim, YL Chen, CW Liew, L Yap, J Lescar, PY Shi Journal of virology 87 (9), 5291-5295, 2013 | 100 | 2013 |
