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Sean Humphrey
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Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation
SJ Humphrey, DE James, M Mann
Trends in Endocrinology & Metabolism 26 (12), 676-687, 2015
5702015
High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics
SJ Humphrey, SB Azimifar, M Mann
Nature Biotechnology 33, 990-995, 2015
4722015
Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2
SJ Humphrey, G Yang, P Yang, DJ Fazakerley, J Stöckli, JY Yang, ...
Cell metabolism 17 (6), 1009-1020, 2013
4502013
Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates
NJ Hoffman, BL Parker, R Chaudhuri, KH Fisher-Wellman, M Kleinert, ...
Cell metabolism 22 (5), 922-935, 2015
4192015
A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
G Yang, DS Murashige, SJ Humphrey, DE James
Cell reports 12 (6), 937-943, 2015
3702015
Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology
MS Robles, SJ Humphrey, M Mann
Cell Metabolism 25 (1), 118-127, 2017
3592017
High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform
SJ Humphrey, O Karayel, DE James, M Mann
Nature protocols 13 (9), 1897, 2018
3082018
Illuminating the dark phosphoproteome
EJ Needham, BL Parker, T Burykin, DE James, SJ Humphrey
Science signaling 12 (565), eaau8645, 2019
2952019
MaxDIA enables library-based and library-free data-independent acquisition proteomics
P Sinitcyn, H Hamzeiy, F Salinas Soto, D Itzhak, F McCarthy, C Wichmann, ...
Nature Biotechnology 39 (12), 1563-1573, 2021
1912021
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection
RJ Mills, SJ Humphrey, PRJ Fortuna, M Lor, SR Foster, GA Quaife-Ryan, ...
Cell 184 (8), 2167-2182. e22, 2021
1672021
Multi-Omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
P Yang, SJ Humphrey, S Cinghu, R Pathania, AJ Oldfield, D Kumar, ...
Cell Systems, 2019
1322019
Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance
DJ Fazakerley, R Chaudhuri, P Yang, GJ Maghzal, KC Thomas, JR Krycer, ...
eLife 7, e32111, 2018
1252018
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes
AY Minard, SX Tan, P Yang, DJ Fazakerley, W Domanova, BL Parker, ...
Cell Reports 17 (1), 29-36, 2016
1242016
In vivo brain GPCR signaling elucidated by phosphoproteomics
JJ Liu, K Sharma, L Zangrandi, C Chen, SJ Humphrey, YT Chiu, M Spetea, ...
Science 360 (6395), eaao4927, 2018
1112018
Global redox proteome and phosphoproteome analysis reveals redox switch in Akt
Z Su, JG Burchfield, P Yang, SJ Humphrey, G Yang, D Francis, S Yasmin, ...
Nature communications 10 (1), 5486, 2019
1012019
Proteomic Analysis of Human Plasma during Intermittent Fasting
DJ Harney, AT Hutchison, L Hatchwell, SJ Humphrey, DE James, ...
Journal of proteome research 18 (5), 2228-2240, 2019
982019
Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
F Sacco, SJ Humphrey, J Cox, M Mischnik, A Schulte, T Klabunde, ...
Nature Communications 7 (1), 13250, 2016
962016
PhosR enables processing and functional analysis of phosphoproteomic data
HJ Kim, T Kim, ...
Cell Reports 34 (8), 108771, 2021
812021
Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets
F Sacco, A Seelig, SJ Humphrey, N Krahmer, F Volta, A Reggio, ...
Cell metabolism 29 (6), 1422-1432. e3, 2019
812019
Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry
BL Parker, G Yang, SJ Humphrey, R Chaudhuri, X Ma, S Peterman, ...
Science Signaling 8 (380), rs6-rs6, 2015
772015
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