Activity-based proteome profiling of potential cellular targets of orlistat− an FDA-approved drug with anti-tumor activities PY Yang, K Liu, MH Ngai, MJ Lear, MR Wenk, SQ Yao Journal of the American Chemical Society 132 (2), 656-666, 2010 | 262 | 2010 |
Practical synthesis of maleimides and coumarin-linked probes for protein and antibody labelling via reduction of native disulfides HY Song, MH Ngai, ZY Song, PA MacAry, J Hobley, MJ Lear Organic & Biomolecular Chemistry 7 (17), 3400-3406, 2009 | 137 | 2009 |
Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome1 [S] SM Lam, L Tong, B Reux, X Duan, A Petznick, SS Yong, CBS Khee, ... Journal of lipid research 55 (2), 299-306, 2014 | 120 | 2014 |
A programmed cell death pathway in the malaria parasite Plasmodium falciparum has general features of mammalian apoptosis but is mediated by clan CA cysteine proteases JH Ch'Ng, SR Kotturi, AGL Chong, MJ Lear, KSW Tan Cell death & disease 1 (2), e26-e26, 2010 | 99 | 2010 |
A bismuth (III)-catalyzed Friedel− Crafts cyclization and stereocontrolled organocatalytic approach to (−)-platensimycin STC Eey, MJ Lear Organic letters 12 (23), 5510-5513, 2010 | 88 | 2010 |
Evaluation of Aroma-Active Compounds in Pontianak Orange Peel Oil (Citrus nobilis Lour. Var. microcarpa Hassk.) by Gas Chromatography−Olfactometry, Aroma … J Dharmawan, S Kasapis, P Sriramula, MJ Lear, P Curran Journal of Agricultural and Food Chemistry 57 (1), 239-244, 2009 | 85 | 2009 |
A Direct and Efficient α‐Selective Glycosylation Protocol for the Kedarcidin Sugar, L‐Mycarose: AgPF6 as a Remarkable Activator of 2‐Deoxythioglycosides MJ Lear, F Yoshimura, M Hirama Angewandte Chemie 113 (5), 972-975, 2001 | 83 | 2001 |
Oxidative amidation of nitroalkanes with amine nucleophiles using molecular oxygen and iodine J Li, MJ Lear, Y Kawamoto, S Umemiya, AR Wong, E Kwon, I Sato, ... Angewandte Chemie International Edition 54 (44), 12986-12990, 2015 | 71 | 2015 |
Stereocontrolled entry to the tricyclo [3.3. 0] oxoheptane core of bielschowskysin by a [2+ 2] cycloaddition of an allene-butenolide R Miao, SG Gramani, MJ Lear Tetrahedron Letters 50 (15), 1731-1733, 2009 | 69 | 2009 |
Efficient construction of the kedarcidin chromophore ansamacrolide Y Koyama, MJ Lear, F Yoshimura, I Ohashi, T Mashimo, M Hirama Organic letters 7 (2), 267-270, 2005 | 66 | 2005 |
Sterically Demanding Oxidative Amidation of α‐Substituted Malononitriles with Amines Using O2 J Li, MJ Lear, Y Hayashi Angewandte Chemie International Edition 55 (31), 9060-9064, 2016 | 63 | 2016 |
Remote 1, 6-Stereocontrol by Iminium-mediated Organocatalytic Events. MJ Lear, Y Hayashi ChemCatChem 5 (12), 2013 | 58 | 2013 |
Click-based synthesis and proteomic profiling of lipstatin analogues MH Ngai, PY Yang, K Liu, Y Shen, MR Wenk, SQ Yao, MJ Lear Chemical communications 46 (44), 8335-8337, 2010 | 53 | 2010 |
Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol AD Rodríguez, MJ Lear, JJ La Clair Journal of the American Chemical Society 130 (23), 7256-7258, 2008 | 45 | 2008 |
The first total synthesis of N1999-A2: absolute stereochemistry and stereochemical implications into DNA cleavage S Kobayashi, S Ashizawa, Y Takahashi, Y Sugiura, M Nagaoka, MJ Lear, ... Journal of the American Chemical Society 123 (45), 11294-11295, 2001 | 45 | 2001 |
Chemical modification and organelle‐specific localization of orlistat‐like natural‐product‐based probes PY Yang, K Liu, C Zhang, GYJ Chen, Y Shen, MH Ngai, MJ Lear, SQ Yao Chemistry–An Asian Journal 6 (10), 2762-2775, 2011 | 44 | 2011 |
Laetirobin from the Parasitic Growth of Laetiporus sulphureus on Robinia pseudoacacia MJ Lear, O Simon, TL Foley, MD Burkart, TJ Baiga, JP Noel, ... Journal of natural products 72 (11), 1980-1987, 2009 | 36 | 2009 |
Biomimetic Total Synthesis of Cyanosporaside Aglycons from a Single Enediyne Precursor through Site‐Selective p‐Benzyne Hydrochlorination K Yamada, MJ Lear, T Yamaguchi, S Yamashita, ID Gridnev, Y Hayashi, ... Angewandte Chemie 126 (50), 14122-14126, 2014 | 35 | 2014 |
Convenient route to derivatives of the 2-deoxysugar subunits of the kedarcidin chromophore: L-mycarose and L-kedarosamine MJ Lear, M Hirama Tetrahedron letters 40 (26), 4897-4900, 1999 | 34 | 1999 |
Rapid and sensitive profiling of tear wax ester species using high performance liquid chromatography coupled with tandem mass spectrometry SM Lam, L Tong, B Reux, MJ Lear, MR Wenk, G Shui Journal of Chromatography A 1308, 166-171, 2013 | 33 | 2013 |