Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner CL Benn, T Sun, G Sadri-Vakili, KN McFarland, DP DiRocco, GJ Yohrling, ... Journal of Neuroscience 28 (42), 10720-10733, 2008 | 278 | 2008 |
Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models G Sadri-Vakili, B Bouzou, CL Benn, MO Kim, P Chawla, RP Overland, ... Human molecular genetics 16 (11), 1293-1306, 2007 | 239 | 2007 |
Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease AS Chen-Plotkin, G Sadri-Vakili, GJ Yohrling, MW Braveman, CL Benn, ... Neurobiology of disease 22 (2), 233-241, 2006 | 138 | 2006 |
Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology GJ Yohrling IV, GCT Jiang, MM DeJohn, DW Miller, AB Young, KE Vrana, ... Molecular Brain Research 119 (1), 28-36, 2003 | 79 | 2003 |
Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study N Carty, N Berson, K Tillack, C Thiede, D Scholz, K Kottig, Y Sedaghat, ... PloS one 10 (4), e0123527, 2015 | 75 | 2015 |
Inhibition of tryptophan hydroxylase activity and decreased 5‐HT1A receptor binding in a mouse model of Huntington's disease GJ Yohrling Iv, GCT Jiang, MM DeJohn, DJ Robertson, KE Vrana, ... Journal of neurochemistry 82 (6), 1416-1423, 2002 | 65 | 2002 |
Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling GCT Jiang, GJ Yohrling, I Schmitt, KE Vrana Journal of molecular biology 302 (4), 1005-1017, 2000 | 53 | 2000 |
Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation GJ Yohrling IV, LA Farrell, AN Hollenberg, JHJ Cha Molecular and Cellular Neuroscience 23 (1), 28-38, 2003 | 50 | 2003 |
Survey of the Huntington’s disease patient and caregiver community reveals most impactful symptoms and treatment needs JA Simpson, D Lovecky, J Kogan, LA Vetter, GJ Yohrling Journal of Huntington's disease 5 (4), 395-403, 2016 | 47 | 2016 |
Striatal synaptosomes from Hdh 140Q/140Q knock-in mice have altered protein levels, novel sites of methionine oxidation, and excess glutamate release after stimulation A Valencia, E Sapp, JS Kimm, H McClory, KA Ansong, G Yohrling, S Kwak, ... Journal of Huntington's disease 2 (4), 459-475, 2013 | 47 | 2013 |
Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons Y Liu, GJ Yohrling, Y Wang, TL Hutchinson, DE Brenneman, CM Flores, ... Epilepsy research 83 (1), 66-72, 2009 | 43 | 2009 |
Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads Y Huang, ED Strobel, CY Ho, CH Reynolds, KA Conway, JA Piesvaux, ... Bioorganic & medicinal chemistry letters 20 (10), 3158-3160, 2010 | 36 | 2010 |
Huntingtin inclusions do not down‐regulate specific genes in the R6/2 Huntington's disease mouse G Sadri‐Vakili, AS Menon, LA Farrell, CE Keller‐McGandy, ... European Journal of Neuroscience 23 (12), 3171-3175, 2006 | 31 | 2006 |
Chromatin immunoprecipitation technique for study of transcriptional dysregulation in intact mouse brain MW Braveman, AS Chen-Plotkin, GJ Yohrling, JHJ Cha Trinucleotide Repeat Protocols, 261-276, 2004 | 22 | 2004 |
Volumetric MRI-based biomarkers in Huntington's disease: an evidentiary review KM Kinnunen, AJ Schwarz, EC Turner, D Pustina, EC Gantman, ... Frontiers in Neurology 12, 712555, 2021 | 20 | 2021 |
Neurochemistry of Huntington's disease GJ Yohrling, JHJ Cha OXFORD MONOGRAPHS ON MEDICAL GENETICS 45, 276-308, 2002 | 19 | 2002 |
Intersubunit binding domains within tyrosine hydroxylase and tryptophan hydroxylase GJ Yohrling IV, GCT Jiang, SM Mockus, KE Vrana Journal of neuroscience research 61 (3), 313-320, 2000 | 16 | 2000 |
Identification of amino-terminal sequences contributing to tryptophan hydroxylase tetramer formation GJ Yohrling, SM Mockus, KE Vrana Journal of Molecular Neuroscience 12, 23-34, 1999 | 15 | 1999 |
Prevalence of Huntington’s disease in the US (954) G Yohrling, K Raimundo, V Crowell, D Lovecky, L Vetter, L Seeberger Neurology 94 (15 Supplement), 2020 | 13 | 2020 |
Epidemiology of Huntington’s disease (HD) in the US medicare population (670) A Exuzides, V Crowell, SR Reddy, E Chang, G Yohrling Neurology 94 (15 Supplement), 2020 | 11 | 2020 |