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William Kelton
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High-resolution antibody dynamics of vaccine-induced immune responses
U Laserson, F Vigneault, D Gadala-Maria, G Yaari, M Uduman, ...
Proceedings of the National Academy of Sciences 111 (13), 4928-4933, 2014
2052014
Bypassing glycosylation: Engineering aglycosylated full-length IgG antibodies for human therapy
ST Jung, TH Kang, W Kelton, G Georgiou
Current Opinion in Biotechnology, 2011
1402011
Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells
G Romain, V Senyukov, N Rey-Villamizar, A Merouane, W Kelton, I Liadi, ...
Blood, The Journal of the American Society of Hematology 124 (22), 3241-3249, 2014
1242014
Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain
JM Taft, CR Weber, B Gao, RA Ehling, J Han, L Frei, SW Metcalfe, ...
Cell 185 (21), 4008-4022. e14, 2022
892022
High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis
DM Mason, CR Weber, C Parola, SM Meng, V Greiff, WJ Kelton, ...
Nucleic Acids Research, 285015, 2018
872018
Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity
ST Jung, W Kelton, TH Kang, DTW Ng, JT Andersen, I Sandlie, CA Sarkar, ...
ACS chemical biology 8 (2), 368-375, 2013
842013
IgGA: a “cross-isotype” engineered human Fc antibody domain that displays both IgG-like and IgA-like effector functions
W Kelton, N Mehta, W Charab, J Lee, C Lee, T Kojima, TH Kang, ...
Chemistry & biology 21 (12), 1603-1609, 2014
732014
Immunogenomic engineering of a plug-and-(dis) play hybridoma platform
M Pogson, C Parola, WJ Kelton, P Heuberger, ST Reddy
Nature communications 7 (1), 12535, 2016
642016
Deep mutational scanning for therapeutic antibody engineering
KR Hanning, M Minot, AK Warrender, W Kelton, ST Reddy
Trends in pharmacological sciences 43 (2), 123-135, 2022
392022
Molecular design, optimization, and genomic integration of chimeric B cell receptors in murine B cells
T Pesch, L Bonati, W Kelton, C Parola, RA Ehling, L Csepregi, D Kitamura, ...
Frontiers in immunology 10, 2630, 2019
322019
Reprogramming MHC specificity by CRISPR-Cas9-assisted cassette exchange
W Kelton, AC Waindok, T Pesch, M Pogson, K Ford, C Parola, ST Reddy
Scientific reports 7 (1), 45775, 2017
272017
Mechanisms of host manipulation by Neisseria gonorrhoeae
E Walker, S van Niekerk, K Hanning, W Kelton, J Hicks
Frontiers in Microbiology 14, 1119834, 2023
192023
Surveying the delivery methods of CRISPR/Cas9 for ex vivo mammalian cell engineering
WJ Kelton, T Pesch, S Matile, ST Reddy
Chimia 70 (6), 439-439, 2016
192016
Digital twins in food processing: A conceptual approach to developing multi-layer digital models
A Isuru, W Kelton, C Bayer
Digital Chemical Engineering 7, 100087, 2023
132023
Beyond allotypes: the influence of allelic diversity in antibody constant domains
AK Warrender, W Kelton
Frontiers in Immunology 11, 2016, 2020
132020
Engineered immunoglobulin FC polypeptides
G Georgiou, ST Jung, W Kelton, TH Kang
US Patent 8,952,132, 2015
92015
Constant domain polymorphisms influence monoclonal antibody stability and dynamics
AK Warrender, J Pan, CR Pudney, VL Arcus, W Kelton
Protein Science 32 (3), e4589, 2023
62023
Antibodies with engineered IgG Fc domains
G Georgiou, W Kelton, N Mehta
US Patent 9,890,216, 2018
62018
Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheep
GM Jacobson, K Kraakman, O Wallace, J Pan, A Hennebry, G Smolenski, ...
Biotechnology Reports 38, e00791, 2023
52023
Impact of prepartum administration of a vaccine against infectious calf diarrhea on nonspecific colostral immunoglobulin concentrations of dairy cows
GP Chambers, W Kelton, G Smolenski, E Cuttance
Journal of Animal Science 100 (8), skac212, 2022
52022
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Articles 1–20