High-resolution antibody dynamics of vaccine-induced immune responses U Laserson, F Vigneault, D Gadala-Maria, G Yaari, M Uduman, ... Proceedings of the National Academy of Sciences 111 (13), 4928-4933, 2014 | 205 | 2014 |
Bypassing glycosylation: Engineering aglycosylated full-length IgG antibodies for human therapy ST Jung, TH Kang, W Kelton, G Georgiou Current Opinion in Biotechnology, 2011 | 140 | 2011 |
Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells G Romain, V Senyukov, N Rey-Villamizar, A Merouane, W Kelton, I Liadi, ... Blood, The Journal of the American Society of Hematology 124 (22), 3241-3249, 2014 | 124 | 2014 |
Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain JM Taft, CR Weber, B Gao, RA Ehling, J Han, L Frei, SW Metcalfe, ... Cell 185 (21), 4008-4022. e14, 2022 | 89 | 2022 |
High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis DM Mason, CR Weber, C Parola, SM Meng, V Greiff, WJ Kelton, ... Nucleic Acids Research, 285015, 2018 | 87 | 2018 |
Effective phagocytosis of low Her2 tumor cell lines with engineered, aglycosylated IgG displaying high FcγRIIa affinity and selectivity ST Jung, W Kelton, TH Kang, DTW Ng, JT Andersen, I Sandlie, CA Sarkar, ... ACS chemical biology 8 (2), 368-375, 2013 | 84 | 2013 |
IgGA: a “cross-isotype” engineered human Fc antibody domain that displays both IgG-like and IgA-like effector functions W Kelton, N Mehta, W Charab, J Lee, C Lee, T Kojima, TH Kang, ... Chemistry & biology 21 (12), 1603-1609, 2014 | 73 | 2014 |
Immunogenomic engineering of a plug-and-(dis) play hybridoma platform M Pogson, C Parola, WJ Kelton, P Heuberger, ST Reddy Nature communications 7 (1), 12535, 2016 | 64 | 2016 |
Deep mutational scanning for therapeutic antibody engineering KR Hanning, M Minot, AK Warrender, W Kelton, ST Reddy Trends in pharmacological sciences 43 (2), 123-135, 2022 | 39 | 2022 |
Molecular design, optimization, and genomic integration of chimeric B cell receptors in murine B cells T Pesch, L Bonati, W Kelton, C Parola, RA Ehling, L Csepregi, D Kitamura, ... Frontiers in immunology 10, 2630, 2019 | 32 | 2019 |
Reprogramming MHC specificity by CRISPR-Cas9-assisted cassette exchange W Kelton, AC Waindok, T Pesch, M Pogson, K Ford, C Parola, ST Reddy Scientific reports 7 (1), 45775, 2017 | 27 | 2017 |
Mechanisms of host manipulation by Neisseria gonorrhoeae E Walker, S van Niekerk, K Hanning, W Kelton, J Hicks Frontiers in Microbiology 14, 1119834, 2023 | 19 | 2023 |
Surveying the delivery methods of CRISPR/Cas9 for ex vivo mammalian cell engineering WJ Kelton, T Pesch, S Matile, ST Reddy Chimia 70 (6), 439-439, 2016 | 19 | 2016 |
Digital twins in food processing: A conceptual approach to developing multi-layer digital models A Isuru, W Kelton, C Bayer Digital Chemical Engineering 7, 100087, 2023 | 13 | 2023 |
Beyond allotypes: the influence of allelic diversity in antibody constant domains AK Warrender, W Kelton Frontiers in Immunology 11, 2016, 2020 | 13 | 2020 |
Engineered immunoglobulin FC polypeptides G Georgiou, ST Jung, W Kelton, TH Kang US Patent 8,952,132, 2015 | 9 | 2015 |
Constant domain polymorphisms influence monoclonal antibody stability and dynamics AK Warrender, J Pan, CR Pudney, VL Arcus, W Kelton Protein Science 32 (3), e4589, 2023 | 6 | 2023 |
Antibodies with engineered IgG Fc domains G Georgiou, W Kelton, N Mehta US Patent 9,890,216, 2018 | 6 | 2018 |
Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheep GM Jacobson, K Kraakman, O Wallace, J Pan, A Hennebry, G Smolenski, ... Biotechnology Reports 38, e00791, 2023 | 5 | 2023 |
Impact of prepartum administration of a vaccine against infectious calf diarrhea on nonspecific colostral immunoglobulin concentrations of dairy cows GP Chambers, W Kelton, G Smolenski, E Cuttance Journal of Animal Science 100 (8), skac212, 2022 | 5 | 2022 |