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Aviad Tsherniak
Aviad Tsherniak
Broad Institute of Harvard and MIT
Verified email at broadinstitute.org - Homepage
Title
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Cited by
Year
Next-generation characterization of the cancer cell line encyclopedia
M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ...
Nature 569 (7757), 503-508, 2019
22552019
Defining a cancer dependency map
A Tsherniak, F Vazquez, PG Montgomery, BA Weir, G Kryukov, ...
Cell 170 (3), 564-576. e16, 2017
19212017
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
RM Meyers, JG Bryan, JM McFarland, BA Weir, AE Sizemore, H Xu, ...
Nature genetics 49 (12), 1779-1784, 2017
14772017
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
YJ Cho, A Tsherniak, P Tamayo, S Santagata, A Ligon, H Greulich, ...
Journal of clinical oncology 29 (11), 1424, 2011
8102011
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
J Rosenbluh, D Nijhawan, AG Cox, X Li, JT Neal, EJ Schafer, TI Zack, ...
Cell 151 (7), 1457-1473, 2012
8002012
Genetic and transcriptional evolution alters cancer cell line drug response
U Ben-David, B Siranosian, G Ha, H Tang, Y Oren, K Hinohara, ...
Nature 560 (7718), 325-330, 2018
7932018
Prognostically relevant gene signatures of high-grade serous ovarian carcinoma
RGW Verhaak, P Tamayo, JY Yang, D Hubbard, H Zhang, CJ Creighton, ...
The Journal of clinical investigation 123 (1), 2012
6372012
Genomic copy number dictates a gene-independent cell response to CRISPR/Cas9 targeting
AJ Aguirre, RM Meyers, BA Weir, F Vazquez, CZ Zhang, U Ben-David, ...
Cancer discovery 6 (8), 914-929, 2016
6272016
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer
HW Cheung, GS Cowley, BA Weir, JS Boehm, S Rusin, JA Scott, A East, ...
Proceedings of the National Academy of Sciences 108 (30), 12372-12377, 2011
4962011
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling
SM Corsello, RT Nagari, RD Spangler, J Rossen, M Kocak, JG Bryan, ...
Nature cancer 1 (2), 235-248, 2020
4822020
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
GS Cowley, BA Weir, F Vazquez, P Tamayo, JA Scott, S Rusin, ...
Scientific data 1 (1), 1-12, 2014
4602014
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
GV Kryukov, FH Wilson, JR Ruth, J Paulk, A Tsherniak, SE Marlow, ...
Science 351 (6278), 1214-1218, 2016
4392016
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
KH Kim, W Kim, TP Howard, F Vazquez, A Tsherniak, JN Wu, W Wang, ...
Nature medicine 21 (12), 1491-1496, 2015
3882015
Mutational processes shape the landscape of TP53 mutations in human cancer
AO Giacomelli, X Yang, RE Lintner, JM McFarland, M Duby, J Kim, ...
Nature genetics 50 (10), 1381-1387, 2018
3742018
The landscape of cancer cell line metabolism
H Li, S Ning, M Ghandi, GV Kryukov, S Gopal, A Deik, A Souza, K Pierce, ...
Nature medicine 25 (5), 850-860, 2019
3662019
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration
JM McFarland, ZV Ho, G Kugener, JM Dempster, PG Montgomery, ...
Nature communications 9 (1), 4610, 2018
3242018
Mitochondrial metabolism promotes adaptation to proteotoxic stress
P Tsvetkov, A Detappe, K Cai, HR Keys, Z Brune, W Ying, P Thiru, ...
Nature chemical biology 15 (7), 681-689, 2019
3042019
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
C Yu, AM Mannan, GM Yvone, KN Ross, YL Zhang, MA Marton, BR Taylor, ...
Nature biotechnology 34 (4), 419-423, 2016
2832016
Extracting biological insights from the project achilles genome-scale CRISPR screens in cancer cell lines
JM Dempster, J Rossen, M Kazachkova, J Pan, G Kugener, DE Root, ...
BioRxiv, 720243, 2019
2762019
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
EM Chan, T Shibue, JM McFarland, B Gaeta, M Ghandi, N Dumont, ...
Nature 568 (7753), 551-556, 2019
2662019
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