| Next-generation characterization of the cancer cell line encyclopedia M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ... Nature 569 (7757), 503-508, 2019 | 2656 | 2019 |
| Defining a cancer dependency map A Tsherniak, F Vazquez, PG Montgomery, BA Weir, G Kryukov, ... Cell 170 (3), 564-576. e16, 2017 | 2263 | 2017 |
| Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells RM Meyers, JG Bryan, JM McFarland, BA Weir, AE Sizemore, H Xu, ... Nature genetics 49 (12), 1779-1784, 2017 | 1660 | 2017 |
| Genetic and transcriptional evolution alters cancer cell line drug response U Ben-David, B Siranosian, G Ha, H Tang, Y Oren, K Hinohara, ... Nature 560 (7718), 325-330, 2018 | 863 | 2018 |
| Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome YJ Cho, A Tsherniak, P Tamayo, S Santagata, A Ligon, H Greulich, ... Journal of clinical oncology 29 (11), 1424-1430, 2011 | 852 | 2011 |
| β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis J Rosenbluh, D Nijhawan, AG Cox, X Li, JT Neal, EJ Schafer, TI Zack, ... Cell 151 (7), 1457-1473, 2012 | 839 | 2012 |
| Genomic copy number dictates a gene-independent cell response to CRISPR/Cas9 targeting AJ Aguirre, RM Meyers, BA Weir, F Vazquez, CZ Zhang, U Ben-David, ... Cancer discovery 6 (8), 914-929, 2016 | 674 | 2016 |
| Prognostically relevant gene signatures of high-grade serous ovarian carcinoma RGW Verhaak, P Tamayo, JY Yang, D Hubbard, H Zhang, CJ Creighton, ... The Journal of clinical investigation 123 (1), 2012 | 663 | 2012 |
| Discovering the anticancer potential of non-oncology drugs by systematic viability profiling SM Corsello, RT Nagari, RD Spangler, J Rossen, M Kocak, JG Bryan, ... Nature cancer 1 (2), 235-248, 2020 | 598 | 2020 |
| Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer HW Cheung, GS Cowley, BA Weir, JS Boehm, S Rusin, JA Scott, A East, ... Proceedings of the National Academy of Sciences 108 (30), 12372-12377, 2011 | 516 | 2011 |
| MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells GV Kryukov, FH Wilson, JR Ruth, J Paulk, A Tsherniak, SE Marlow, ... Science 351 (6278), 1214-1218, 2016 | 506 | 2016 |
| Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies GS Cowley, BA Weir, F Vazquez, P Tamayo, JA Scott, S Rusin, ... Scientific data 1 (1), 1-12, 2014 | 477 | 2014 |
| Mutational processes shape the landscape of TP53 mutations in human cancer AO Giacomelli, X Yang, RE Lintner, JM McFarland, M Duby, J Kim, ... Nature genetics 50 (10), 1381-1387, 2018 | 444 | 2018 |
| The landscape of cancer cell line metabolism H Li, S Ning, M Ghandi, GV Kryukov, S Gopal, A Deik, A Souza, K Pierce, ... Nature medicine 25 (5), 850-860, 2019 | 432 | 2019 |
| SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 KH Kim, W Kim, TP Howard, F Vazquez, A Tsherniak, JN Wu, W Wang, ... Nature medicine 21 (12), 1491-1496, 2015 | 421 | 2015 |
| Mitochondrial metabolism promotes adaptation to proteotoxic stress P Tsvetkov, A Detappe, K Cai, HR Keys, Z Brune, W Ying, P Thiru, ... Nature chemical biology 15 (7), 681-689, 2019 | 385 | 2019 |
| Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration JM McFarland, ZV Ho, G Kugener, JM Dempster, PG Montgomery, ... Nature communications 9 (1), 4610, 2018 | 351 | 2018 |
| High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines C Yu, AM Mannan, GM Yvone, KN Ross, YL Zhang, MA Marton, BR Taylor, ... Nature biotechnology 34 (4), 419-423, 2016 | 324 | 2016 |
| Extracting biological insights from the project achilles genome-scale CRISPR screens in cancer cell lines JM Dempster, J Rossen, M Kazachkova, J Pan, G Kugener, DE Root, ... BioRxiv, 720243, 2019 | 321 | 2019 |
| WRN helicase is a synthetic lethal target in microsatellite unstable cancers EM Chan, T Shibue, JM McFarland, B Gaeta, M Ghandi, N Dumont, ... Nature 568 (7753), 551-556, 2019 | 311 | 2019 |
Francisca VazquezDirector, Cancer Dependency Map, Broad InstituteVerified email at broadinstitute.org
