Kendall W Nettles
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Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism
AK Shiau, D Barstad, JT Radek, MJ Meyers, KW Nettles, ...
Nature structural biology 9 (5), 359-364, 2002
Manifesto for a higher T c
DN Basov, AV Chubukov
Nature Physics 7 (4), 272-276, 2011
Partial agonists activate PPARγ using a helix 12 independent mechanism
JB Bruning, MJ Chalmers, S Prasad, SA Busby, TM Kamenecka, Y He, ...
Structure 15 (10), 1258-1271, 2007
Ligand control of coregulator recruitment to nuclear receptors
KW Nettles, GL Greene
Annu. Rev. Physiol. 67, 309-333, 2005
NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
KW Nettles, JB Bruning, G Gil, J Nowak, SK Sharma, JB Hahm, K Kulp, ...
Nature chemical biology 4 (4), 241-247, 2008
Structural plasticity in the oestrogen receptor ligand‐binding domain
KW Nettles, JB Bruning, G Gil, EE O'Neill, J Nowak, A Hughs, Y Kim, ...
EMBO reports 8 (6), 563-568, 2007
Coupling of receptor conformation and ligand orientation determine graded activity
JB Bruning, AA Parent, G Gil, M Zhao, J Nowak, MC Pace, CL Smith, ...
Nature chemical biology 6 (11), 837-843, 2010
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis
Y Zhao, P Gong, Y Chen, JC Nwachukwu, S Srinivasan, CM Ko, ...
Science translational medicine 7 (271), 271ra9-271ra9, 2015
Allosteric control of ligand selectivity between estrogen receptors α and β: implications for other nuclear receptors
KW Nettles, J Sun, JT Radek, S Sheng, AL Rodriguez, ...
Molecular cell 13 (3), 317-327, 2004
Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network
JC Nwachukwu, S Srinivasan, NE Bruno, AA Parent, TS Hughes, ...
Elife 3, e02057, 2014
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
DJ Kojetin, E Matta-Camacho, TS Hughes, S Srinivasan, JC Nwachukwu, ...
Nature communications 6 (1), 1-14, 2015
Structural and molecular mechanisms of cytokine-mediated endocrine resistance in human breast cancer cells
JD Stender, JC Nwachukwu, I Kastrati, Y Kim, T Strid, M Yakir, ...
Molecular cell 65 (6), 1122-1135. e5, 2017
CBP is a dosage-dependent regulator of nuclear factor-κB suppression by the estrogen receptor
KW Nettles, G Gil, J Nowak, R Métivier, VB Sharma, GL Greene
Molecular endocrinology 22 (2), 263-272, 2008
Creb coactivators direct anabolic responses and enhance performance of skeletal muscle
NE Bruno, KA Kelly, R Hawkins, M Bramah‐Lawani, AL Amelio, ...
The EMBO journal 33 (9), 1027-1043, 2014
Elemental isomerism: A boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands
HB Zhou, KW Nettles, JB Bruning, Y Kim, A Joachimiak, S Sharma, ...
Chemistry & biology 14 (6), 659-669, 2007
Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α
S Srinivasan, JC Nwachukwu, AA Parent, V Cavett, J Nowak, TS Hughes, ...
Nature chemical biology 9 (5), 326-332, 2013
Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains
HB Zhou, S Sheng, DR Compton, Y Kim, A Joachimiak, S Sharma, ...
Journal of medicinal chemistry 50 (2), 399-403, 2007
Influence of the ventral hippocampal formation on plasma vasopressin, hypothalamic-pituitary-adrenal axis, and behavioral responses to novel acoustic stress
KW Nettles, C Pesold, MB Goldman
Brain research 858 (1), 181-190, 2000
Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements
WH Hudson, IMS de Vera, JC Nwachukwu, ER Weikum, AG Herbst, ...
Nature communications 9 (1), 1-13, 2018
Thiophene-core estrogen receptor ligands having superagonist activity
J Min, P Wang, S Srinivasan, JC Nwachukwu, P Guo, M Huang, ...
Journal of medicinal chemistry 56 (8), 3346-3366, 2013
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