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Kendall W Nettles
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Year
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism
AK Shiau, D Barstad, JT Radek, MJ Meyers, KW Nettles, ...
Nature structural biology 9 (5), 359-364, 2002
4792002
Partial agonists activate PPARγ using a helix 12 independent mechanism
JB Bruning, MJ Chalmers, S Prasad, SA Busby, TM Kamenecka, Y He, ...
Structure 15 (10), 1258-1271, 2007
3942007
Ligand control of coregulator recruitment to nuclear receptors
KW Nettles, GL Greene
Annu. Rev. Physiol. 67, 309-333, 2005
3152005
NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
KW Nettles, JB Bruning, G Gil, J Nowak, SK Sharma, JB Hahm, K Kulp, ...
Nature chemical biology 4 (4), 241-247, 2008
1722008
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis
Y Zhao, P Gong, Y Chen, JC Nwachukwu, S Srinivasan, CM Ko, ...
Science translational medicine 7 (271), 271ra9-271ra9, 2015
1642015
Structural plasticity in the oestrogen receptor ligand‐binding domain
KW Nettles, JB Bruning, G Gil, EE O'Neill, J Nowak, A Hughs, Y Kim, ...
EMBO reports 8 (6), 563-568, 2007
1472007
Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network
JC Nwachukwu, S Srinivasan, NE Bruno, AA Parent, TS Hughes, ...
elife 3, e02057, 2014
1412014
Coupling of receptor conformation and ligand orientation determine graded activity
JB Bruning, AA Parent, G Gil, M Zhao, J Nowak, MC Pace, CL Smith, ...
Nature chemical biology 6 (11), 837-843, 2010
1382010
Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
DJ Kojetin, E Matta-Camacho, TS Hughes, S Srinivasan, JC Nwachukwu, ...
Nature communications 6 (1), 8013, 2015
1312015
Allosteric control of ligand selectivity between estrogen receptors α and β: implications for other nuclear receptors
KW Nettles, J Sun, JT Radek, S Sheng, AL Rodriguez, ...
Molecular cell 13 (3), 317-327, 2004
1232004
Structural and molecular mechanisms of cytokine-mediated endocrine resistance in human breast cancer cells
JD Stender, JC Nwachukwu, I Kastrati, Y Kim, T Strid, M Yakir, ...
Molecular cell 65 (6), 1122-1135. e5, 2017
1082017
Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements
WH Hudson, IMS Vera, JC Nwachukwu, ER Weikum, AG Herbst, Q Yang, ...
Nature communications 9 (1), 1337, 2018
1042018
Creb coactivators direct anabolic responses and enhance performance of skeletal muscle
NE Bruno, KA Kelly, R Hawkins, M Bramah‐Lawani, AL Amelio, ...
The EMBO journal 33 (9), 1027-1043, 2014
972014
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
SW Fanning, R Jeselsohn, V Dharmarajan, CG Mayne, M Karimi, ...
Elife 7, e37161, 2018
882018
CBP is a dosage-dependent regulator of nuclear factor-κB suppression by the estrogen receptor
KW Nettles, G Gil, J Nowak, R Métivier, VB Sharma, GL Greene
Molecular endocrinology 22 (2), 263-272, 2008
862008
Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands
HB Zhou, KW Nettles, JB Bruning, Y Kim, A Joachimiak, S Sharma, ...
Chemistry & biology 14 (6), 659-669, 2007
762007
Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes
ER Weikum, IMS de Vera, JC Nwachukwu, WH Hudson, KW Nettles, ...
Nucleic acids research 45 (14), 8596-8608, 2017
702017
Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α
S Srinivasan, JC Nwachukwu, AA Parent, V Cavett, J Nowak, TS Hughes, ...
Nature chemical biology 9 (5), 326-332, 2013
652013
Thiophene-core estrogen receptor ligands having superagonist activity
J Min, P Wang, S Srinivasan, JC Nwachukwu, P Guo, M Huang, ...
Journal of medicinal chemistry 56 (8), 3346-3366, 2013
602013
Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains
HB Zhou, S Sheng, DR Compton, Y Kim, A Joachimiak, S Sharma, ...
Journal of medicinal chemistry 50 (2), 399-403, 2007
602007
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