Luk H. Vandenberghe, Ph.D.
Luk H. Vandenberghe, Ph.D.
Grousbeck Family Chair in Gene Therapy, Associate Professor of Ophthalmology, Harvard University
Verified email at - Homepage
Cited by
Cited by
Clades of Adeno-associated viruses are widely disseminated in human tissues
G Gao, LH Vandenberghe, MR Alvira, Y Lu, R Calcedo, X Zhou, ...
Journal of virology 78 (12), 6381-6388, 2004
In vivo gene editing in dystrophic mouse muscle and muscle stem cells
M Tabebordbar, K Zhu, JKW Cheng, WL Chew, JJ Widrick, WX Yan, ...
Science 351 (6271), 407-411, 2016
Worldwide epidemiology of neutralizing antibodies to adeno-associated viruses
R Calcedo, LH Vandenberghe, G Gao, J Lin, JM Wilson
The Journal of infectious diseases 199 (3), 381-390, 2009
New recombinant serotypes of AAV vectors
G Gao, LH Vandenberghe, JM Wilson
Current gene therapy 5 (3), 285-297, 2005
Adeno-associated viruses undergo substantial evolution in primates during natural infections
G Gao, MR Alvira, S Somanathan, Y Lu, LH Vandenberghe, JJ Rux, ...
Proceedings of the National Academy of Sciences 100 (10), 6081-6086, 2003
DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells
G Simmons, JD Reeves, CC Grogan, LH Vandenberghe, F Baribaud, ...
Virology 305 (1), 115-123, 2003
Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale
M Lock, M Alvira, LH Vandenberghe, A Samanta, J Toelen, Z Debyser, ...
Human gene therapy 21 (10), 1259-1271, 2010
Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain
JM Taymans, LH Vandenberghe, CVD Haute, I Thiry, CM Deroose, ...
Human gene therapy 18 (3), 195-206, 2007
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses therefor
JM Wilson, G Gao, MR Alvira, LH Vandenberghe
US Patent 7,906,111, 2011
In silico reconstruction of the viral evolutionary lineage yields a potent gene therapy vector
E Zinn, S Pacouret, V Khaychuk, HT Turunen, LS Carvalho, ...
Cell reports 12 (6), 1056-1068, 2015
Novel adeno-associated virus serotypes efficiently transduce murine photoreceptors
M Allocca, C Mussolino, M Garcia-Hoyos, D Sanges, C Iodice, M Petrillo, ...
Journal of virology 81 (20), 11372-11380, 2007
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
LD Landegger, B Pan, C Askew, SJ Wassmer, SD Gluck, A Galvin, ...
Nature biotechnology 35 (3), 280-284, 2017
Therapeutic AAV gene transfer to the nervous system: a clinical reality
E Hudry, LH Vandenberghe
Neuron 101 (5), 839-862, 2019
Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c
B Pan, C Askew, A Galvin, S Heman-Ackah, Y Asai, AA Indzhykulian, ...
Nature biotechnology 35 (3), 264-272, 2017
Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver
E Breous, S Somanathan, LH Vandenberghe, JM Wilson
Hepatology 50 (2), 612-621, 2009
Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid
LH Vandenberghe, L Wang, S Somanathan, Y Zhi, J Figueredo, ...
Nature medicine 12 (8), 967-971, 2006
Progress in gene therapy for neurological disorders
M Simonato, J Bennett, NM Boulis, MG Castro, DJ Fink, WF Goins, ...
Nature Reviews Neurology 9 (5), 277-291, 2013
Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey
LH Vandenberghe, P Bell, AM Maguire, CN Cearley, R Xiao, R Calcedo, ...
Science translational medicine 3 (88), 88ra54-88ra54, 2011
The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
CL Bell, LH Vandenberghe, P Bell, MP Limberis, GP Gao, K Van Vliet, ...
The Journal of clinical investigation 121 (6), 2427-2435, 2011
CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary humaná…
RV Parry, CA Rumbley, LH Vandenberghe, CH June, JL Riley
The Journal of immunology 171 (1), 166-174, 2003
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