| VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and … JC Hamrick, JD Docquier, T Uehara, CL Myers, DA Six, CL Chatwin, ... Antimicrobial Agents and Chemotherapy 64 (3), 10.1128/aac. 01963-19, 2020 | 153 | 2020 |
| Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase MA Farha, TL Czarny, CL Myers, LJ Worrall, S French, DG Conrady, ... Proceedings of the National Academy of Sciences 112 (35), 11048-11053, 2015 | 107 | 2015 |
| Identification of two phosphate starvation-induced wall teichoic acid hydrolases provides first insights into the degradative pathway of a key bacterial cell wall component CL Myers, FKK Li, BM Koo, OM El-Halfawy, S French, CA Gross, ... Journal of Biological Chemistry 291 (50), 26066-26082, 2016 | 40 | 2016 |
| Semi-synthetic analogues of thiostrepton delimit the critical nature of tail region modifications in the control of protein biosynthesis and antibacterial activity CL Myers, PC Hang, G Ng, J Yuen, JF Honek Bioorganic & medicinal chemistry 18 (12), 4231-4237, 2010 | 40 | 2010 |
| Microbiological characterization of VNRX-5236, a broad-spectrum β-lactamase inhibitor for rescue of the orally bioavailable cephalosporin ceftibuten as a carbapenem-sparing … CL Chatwin, JC Hamrick, REL Trout, CL Myers, SM Cusick, WJ Weiss, ... Antimicrobial Agents and Chemotherapy 65 (8), 10.1128/aac. 00552-21, 2021 | 20 | 2021 |
| Characterization of wall teichoic acid degradation by the bacteriophage ϕ29 appendage protein GP12 using synthetic substrate analogs CL Myers, RG Ireland, TA Garrett, ED Brown Journal of Biological Chemistry 290 (31), 19133-19145, 2015 | 16 | 2015 |
| Penicillin-binding protein inhibitors J Burns, D Daigle, GH Chu, J Hamrick, M Lucas, SA Boyd, AL Zulli, ... WO2018218190, November 29, 2018 | 14 | 2018 |
| Molecular Interactions between Thiostrepton and the TipAS Protein from Streptomyces lividans CL Myers, J Harris, JCK Yeung, JF Honek ChemBioChem 15 (5), 681-687, 2014 | 11 | 2014 |
| A cell-based approach to characterize antimicrobial compounds through kinetic dose response CR MacNair, JM Stokes, S French, CL Myers, KR Iyer, ED Brown Bioorganic & Medicinal Chemistry 24 (24), 6315-6319, 2016 | 9 | 2016 |
| Ceftibuten/VNRX-7145, an orally bioavailable β-lactam/β-lactamase inhibitor combination active against serine-β-lactamase-producing Enterobacteriaceae CL Myers, DM Daigle, CJ Burns, DC Pevear Proceedings of the ECCMID, 2019 | 5 | 2019 |
| Penicillin-binding protein inhibitors CJ Burns, D Daigle, GH Chu, J Hamrick, M Lucas, SA Boyd, AL Zulli, ... US Patent 11,332,485, 2022 | 4 | 2022 |
| Penicillin-binding protein inhibitors CJ Burns, D Daigle, GH Chu, J Hamrick, SA Boyd, AL Zulli, EF Mesaros, ... US Patent App. 17/057,593, 2021 | 3 | 2021 |
| Functional roles in S-adenosyl-L-methionine binding and catalysis for active site residues of the thiostrepton resistance methyltransferase CL Myers, EG Kuiper, PC Grant, J Hernandez, GL Conn, JF Honek FEBS letters 589 (21), 3263-3270, 2015 | 3 | 2015 |
| Penicillin-binding protein inhibitors CJ Burns, D Daigle, GH Chu, J Hamrick, SA Boyd, AL Zulli, SM Condon, ... US Patent App. 17/779,804, 2023 | | 2023 |
| Combination compositions comprising a beta-lactamase inhibitor and uses thereof CJ Burns, D Daigle, J Hamrick, DC Pevear, REL TROUT, L Xerri, ... US Patent App. 17/296,371, 2022 | | 2022 |
| Compositions mixtes comprenant un inhibiteur de bêta-lactamase et leurs utilisations CJ Burns, SM Condon, D Daigle, A Drager, J Hamrick, T Henkel, ... | | 2021 |
| Combination compositions comprising a beta-lactamase inhibitor and uses thereof CJ Burns, D Daigle, J HAMRICK, DC Pevear, REL TROUT, L XERRI, ... | | 2020 |
| Investigations of the Natural Product Antibiotic Thiostrepton from Streptomyces azureus and Associated Mechanisms of Resistance CL Myers University of Waterloo, 2013 | | 2013 |
Eric D BrownProfessor of Biochemistry, McMaster UniversityVerified email at mcmaster.ca
