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Karyn Schmidt
Karyn Schmidt
Scientist
Verified email at dfci.harvard.edu
Title
Cited by
Cited by
Year
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates
CR Brown, S Gupta, J Qin, T Racie, G He, S Lentini, R Malone, M Yu, ...
Nucleic acids research 48 (21), 11827-11844, 2020
1652020
Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2
K Schmidt, DM Wolfe, B Stiller, DA Pearce
Biochemical and biophysical research communications 383 (2), 198-202, 2009
1592009
Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity
K Schmidt, JS Butler
Wiley Interdisciplinary Reviews: RNA 4 (2), 217-231, 2013
1232013
The lncRNA SLNCR1 mediates melanoma invasion through a conserved SRA1-like region
K Schmidt, CE Joyce, F Buquicchio, A Brown, J Ritz, RJ Distel, CH Yoon, ...
Cell reports 15 (9), 2025-2037, 2016
1132016
The lncRNA SLNCR recruits the androgen receptor to EGR1-bound genes in melanoma and inhibits expression of tumor suppressor p21
K Schmidt, JS Carroll, E Yee, DD Thomas, L Wert-Lamas, SC Neier, ...
Cell reports 27 (8), 2493-2507. e4, 2019
672019
Targeting the oncogenic long non-coding RNA SLNCR1 by blocking its sequence-specific binding to the androgen receptor
K Schmidt, CA Weidmann, TA Hilimire, E Yee, BM Hatfield, ...
Cell reports 30 (2), 541-554. e5, 2020
522020
Repeated blood–brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase 1 trial
AM Sonabend, A Gould, C Amidei, R Ward, KA Schmidt, DY Zhang, ...
The Lancet Oncology 24 (5), 509-522, 2023
462023
The nonclinical disposition and pharmacokinetic/pharmacodynamic properties of N-Acetylgalactosamine–conjugated small interfering RNA are highly predictable and build confidence …
R McDougall, D Ramsden, S Agarwal, S Agarwal, K Aluri, M Arciprete, ...
Drug Metabolism and Disposition 50 (6), 781-797, 2022
372022
Air proteins control differential TRAMP substrate specificity for nuclear RNA surveillance
K Schmidt, Z Xu, DH Mathews, JS Butler
Rna 18 (10), 1934-1945, 2012
372012
The nonclinical disposition and PK/PD properties of GalNAc-conjugated siRNA are highly predictable and build confidence in translation to man
S Chong, S Agarwal, S Agarwal, KC Aluri, M Arciprete, C Brown, ...
Drug Metabolism and Disposition, 2021
192021
Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site
B Hamilton, A Manzella, K Schmidt, V DiMarco, JS Butler
PLoS One 9 (11), e112921, 2014
142014
Interobserver reproducibility of visually interpreted EGFR immunohistochemical staining in non-small-cell lung cancer
M Janas, WA Franklin, K Schmidt, LR Bailey
Proc Am Assoc Cancer Res 44, abstrLB-213, 2003
62003
Compositions and methods for treating AR- and/or lncRNA-mediated diseases
CN Karyn A Schmidt
4*
RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes
M Subramanian, J McIninch, I Zlatev, MK Schlegel, C Kaittanis, T Nguyen, ...
Nature Communications 14 (1), 1970, 2023
32023
RATA: A method for high-throughput identification of RNA bound transcription factors
K Schmidt, F Buquicchio, JS Carroll, RJ Distel, CD Novina
Journal of biological methods 4 (1), 2017
32017
Compositions and methods for identification, assessment, prevention, and treatment of cancer using slncr isoforms
K Schmidt, C Novina
US Patent App. 15/741,317, 2019
22019
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex
D Datta, CS Theile, K Wassarman, J Qin, T Racie, K Schmidt, Y Jiang, ...
Chemical Communications 59 (42), 6347-6350, 2023
12023
NAR Breakthrough Article Investigating the pharmacodynamic durability of
CR Brown, S Gupta, J Qin, T Racie, G He, S Lentini, R Malone, M Yu, ...
Nucleic Acids Research 48 (21), 11827-11844, 2020
12020
Compositions and Methods for Identification, Assessment, Prevention, and Treatment of Cancer Using SLNCR Isoforms
KSCD Novina
US Patent PCT/US2016/041,343, 2017
2017
Cd {sup 2+}, Mn {sup 2+}, Ni {sup 2+} and Se {sup 2+} toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2
K Schmidt, DM Wolfe, B Stiller
Biochemical and Biophysical Research Communications 383 (2), 2009
2009
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