Kian Leong LEE
Kian Leong LEE
Senior Research Fellow, Duke-NUS Medical School
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Generating specificity and diversity in the transcriptional response to hypoxia
U Lendahl, KL Lee, H Yang, L Poellinger
Nature Reviews Genetics 10 (12), 821-832, 2009
Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations
KM Loh, LT Ang, J Zhang, V Kumar, J Ang, JQ Auyeong, KL Lee, ...
Cell stem cell 14 (2), 237-252, 2014
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
PA Tyrakis, A Palazon, D Macias, KL Lee, AT Phan, P Veliša, J You, ...
Nature 540 (7632), 236-241, 2016
Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-β signaling
Y Nagano, KJ Mavrakis, KL Lee, T Fujii, D Koinuma, H Sase, K Yuki, ...
Journal of Biological Chemistry 282 (28), 20492-20501, 2007
A roadmap for human liver differentiation from pluripotent stem cells
LT Ang, AKY Tan, MI Autio, SH Goh, SH Choo, KL Lee, J Tan, B Pan, ...
Cell reports 22 (8), 2190-2205, 2018
Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ
S Jin, AP Mutvei, IV Chivukula, ER Andersson, D Ramsk÷ld, R Sandberg, ...
Oncogene 32 (41), 4892-4902, 2013
Heparan sulfation–dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state
F Lanner, KL Lee, M Sohl, K Holmborn, H Yang, J Wilbertz, L Poellinger, ...
Stem cells 28 (2), 191-200, 2010
A human pluripotent stem cell model of facioscapulohumeral muscular dystrophy-affected skeletal muscles
L Caron, D Kher, KL Lee, R McKernan, B Dumevska, A Hidalgo, J Li, ...
Stem cells translational medicine 5 (9), 1145-1161, 2016
Arkadia enhances Nodal/TGF-β signaling by coupling phospho-Smad2/3 activity and turnover
KJ Mavrakis, RL Andrew, KL Lee, C Petropoulou, JE Dixon, ...
PLoS biology 5 (3), e67, 2007
Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions
KL Lee, SK Lim, YL Orlov, LY Yit, H Yang, LT Ang, L Poellinger, B Lim
PLoS genetics 7 (6), e1002130, 2011
Down-regulation of Myc is essential for terminal erythroid maturation
SR Jayapal, KL Lee, P Ji, P Kaldis, B Lim, HF Lodish
Journal of Biological Chemistry 285 (51), 40252-40265, 2010
Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition
KP Ng, A Manjeri, KL Lee, W Huang, SY Tan, CTH Chuah, L Poellinger, ...
Blood, The Journal of the American Society of Hematology 123 (21), 3316-3326, 2014
Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells
W Chien, LW Ding, QY Sun, LA Torres-Fernandez, SZ Tan, J Xiao, SL Lim, ...
Oncotarget 5 (13), 4881, 2014
Hypoxia is a key driver of alternative splicing in human breast cancer cells
J Han, J Li, JC Ho, GS Chia, H Kato, S Jha, H Yang, L Poellinger, KL Lee
Scientific reports 7 (1), 4108, 2017
Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer
W Chien, QY Sun, KL Lee, LW Ding, P Wuensche, LA Torres-Fernandez, ...
Molecular Oncology 9 (4), 889-905, 2015
The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth
J Ueda, JC Ho, KL Lee, S Kitajima, H Yang, W Sun, N Fukuhara, N Zaiden, ...
Molecular and cellular biology 34 (19), 3702-3720, 2014
Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells
M Guzman-Ayala, KL Lee, KJ Mavrakis, P Goggolidou, DP Norris, ...
PLoS One 4 (1), e4268, 2009
An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia
TK Ko, A Javed, KL Lee, TN Pathiraja, X Liu, S Malik, SX Soh, XT Heng, ...
Blood, The Journal of the American Society of Hematology 135 (26), 2337-2353, 2020
Interactions between Notch-and hypoxia-induced transcriptomes in embryonic stem cells
H Main, KL Lee, H Yang, S Haapa-Paananen, H Edgren, S Jin, ...
Experimental cell research 316 (9), 1610-1624, 2010
PIAS4 is an activator of hypoxia signalling via VHL suppression during growth of pancreatic cancer cells
W Chien, KL Lee, LW Ding, P Wuensche, H Kato, NB Doan, L Poellinger, ...
British journal of cancer 109 (7), 1795-1804, 2013
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