Skeletal muscle excitation–contraction coupling: who are the dancing partners? RT Rebbeck, Y Karunasekara, PG Board, NA Beard, MG Casarotto, ... The international journal of biochemistry & cell biology 48, 28-38, 2014 | 133 | 2014 |
High-throughput screens to discover small-molecule modulators of ryanodine receptor calcium release channels RT Rebbeck, MM Essawy, FR Nitu, BD Grant, GD Gillispie, DD Thomas, ... SLAS DISCOVERY: Advancing Life Sciences R&D 22 (2), 176-186, 2017 | 61 | 2017 |
The β1a subunit of the skeletal DHPR binds to skeletal RyR1 and activates the channel via its 35-residue C-terminal tail RT Rebbeck, Y Karunasekara, EM Gallant, PG Board, NA Beard, ... Biophysical journal 100 (4), 922-930, 2011 | 56 | 2011 |
Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic SM Batiste, DJ Blackwell, K Kim, DO Kryshtal, N Gomez-Hurtado, ... Proceedings of the National Academy of Sciences 116 (11), 4810-4815, 2019 | 47 | 2019 |
The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1. 5 and RyR2 function CN Johnson, R Pattanayek, F Potet, RT Rebbeck, DJ Blackwell, ... Cell Calcium 82, 102063, 2019 | 45 | 2019 |
S100A1 protein does not compete with calmodulin for ryanodine receptor binding but structurally alters the ryanodine receptor· calmodulin complex RT Rebbeck, FR Nitu, D Rohde, P Most, DM Bers, DD Thomas, ... Journal of Biological Chemistry 291 (30), 15896-15907, 2016 | 38 | 2016 |
Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators A Lindsay, CW Baumann, RT Rebbeck, SL Yuen, WM Southern, ... Skeletal muscle 10, 1-14, 2020 | 35 | 2020 |
RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays RT Rebbeck, DP Singh, KA Janicek, DM Bers, DD Thomas, ... Scientific reports 10 (1), 1791, 2020 | 31 | 2020 |
Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814 K Walweel, N Gomez-Hurtado, RT Rebbeck, YW Oo, NA Beard, ... Journal of molecular and cellular cardiology 130, 96-106, 2019 | 24 | 2019 |
An α‐helical C‐terminal tail segment of the skeletal L‐type Ca2+ channel β1a subunit activates ryanodine receptor type 1 via a hydrophobic surface Y Karunasekara, RT Rebbeck, LM Weaver, PG Board, AF Dulhunty, ... The FASEB Journal 26 (12), 5049-5059, 2012 | 22 | 2012 |
β1a490–508, a 19-residue peptide from C-terminal tail of Cav1. 1 β1a subunit, potentiates voltage-dependent calcium release in adult skeletal muscle fibers EO Hernández-Ochoa, RO Olojo, RT Rebbeck, AF Dulhunty, ... Biophysical journal 106 (3), 535-547, 2014 | 17 | 2014 |
A large-scale high-throughput screen for modulators of SERCA activity PA Bidwell, SL Yuen, J Li, K Berg, RT Rebbeck, CC Aldrich, ... Biomolecules 12 (12), 1789, 2022 | 11 | 2022 |
The functional significance of redox-mediated intersubunit cross-linking in regulation of human type 2 ryanodine receptor R Nikolaienko, E Bovo, RT Rebbeck, D Kahn, DD Thomas, RL Cornea, ... Redox Biology 37, 101729, 2020 | 11 | 2020 |
Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit RT Rebbeck, H Willemse, L Groom, MG Casarotto, PG Board, NA Beard, ... Skeletal muscle 5, 1-15, 2015 | 9 | 2015 |
Synergistic FRET assays for drug discovery targeting RyR2 channels RT Rebbeck, KS Ginsburg, CY Ko, A Fasoli, K Rusch, GF Cai, X Dong, ... Journal of molecular and cellular cardiology 168, 13-23, 2022 | 8 | 2022 |
Novel drug discovery platform for spinocerebellar ataxia, using fluorescence technology targeting β-III-spectrin RT Rebbeck, AK Andrick, SA Denha, B Svensson, P Guhathakurta, ... Journal of Biological Chemistry 296, 2021 | 8 | 2021 |
CaMKIIδ post-translational modifications increase affinity for calmodulin inside cardiac ventricular myocytes M Simon, CY Ko, RT Rebbeck, S Baidar, RL Cornea, DM Bers Journal of molecular and cellular cardiology 161, 53-61, 2021 | 4 | 2021 |
Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators O Roopnarine, SL Yuen, AR Thompson, LN Roelike, RT Rebbeck, ... Scientific reports 13 (1), 10673, 2023 | 3 | 2023 |
Early-phase drug discovery of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia type 5 P Guhathakurta, RT Rebbeck, SA Denha, AR Keller, AL Carter, AE Atang, ... Journal of Biological Chemistry 299 (3), 2023 | 3 | 2023 |
Interactions between dihydropyridine β1A subunit and ryanodine receptor isoforms RT Rebbeck, H Willemse, L Groom, RT Dirksen, AF Dulhunty Biophysical Journal 104 (2), 105a, 2013 | 2 | 2013 |