Tracking genome engineering outcome at individual DNA breakpoints MT Certo, BY Ryu, JE Annis, M Garibov, J Jarjour, DJ Rawlings, ... Nature methods 8 (8), 671-676, 2011 | 386 | 2011 |
Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template BD Sather, GS Romano Ibarra, K Sommer, G Curinga, M Hale, IF Khan, ... Science translational medicine 7 (307), 307ra156-307ra156, 2015 | 273 | 2015 |
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering S Boissel, J Jarjour, A Astrakhan, A Adey, A Gouble, P Duchateau, ... Nucleic acids research 42 (4), 2591-2601, 2014 | 247 | 2014 |
Fanconi anemia gene editing by the CRISPR/Cas9 system MJ Osborn, R Gabriel, BR Webber, AP DeFeo, AN McElroy, J Jarjour, ... Human gene therapy 26 (2), 114-126, 2015 | 129 | 2015 |
Exploitation of binding energy for catalysis and design SB Thyme, J Jarjour, R Takeuchi, JJ Havranek, J Ashworth, ... Nature 461 (7268), 1300-1304, 2009 | 110 | 2009 |
High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display J Jarjour, H West-Foyle, MT Certo, CG Hubert, L Doyle, MM Getz, ... Nucleic acids research 37 (20), 6871-6880, 2009 | 69 | 2009 |
Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization WH Leung, J Gay, U Martin, TE Garrett, HM Horton, MT Certo, BR Blazar, ... JCI insight 4 (11), 2019 | 61 | 2019 |
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases S Baxter, AR Lambert, R Kuhar, J Jarjour, N Kulshina, F Parmeggiani, ... Nucleic acids research 40 (16), 7985-8000, 2012 | 57 | 2012 |
LAHEDES: the LAGLIDADG homing endonuclease database and engineering server GK Taylor, LH Petrucci, AR Lambert, SK Baxter, J Jarjour, BL Stoddard Nucleic acids research 40 (W1), W110-W116, 2012 | 56 | 2012 |
Multipartite signaling proteins and uses thereof J Jarjour, A Astrakhan, M Certo US Patent 10,428,142, 2019 | 48 | 2019 |
The design and in vivo evaluation of engineered I-OnuI-based enzymes for HEG gene drive YS Chan, R Takeuchi, J Jarjour, DS Huen, BL Stoddard, S Russell PloS one 8 (9), e74254, 2013 | 44 | 2013 |
Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space K Jacoby, M Metzger, BW Shen, MT Certo, J Jarjour, BL Stoddard, ... Nucleic acids research 40 (11), 4954-4964, 2012 | 39 | 2012 |
Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases P Volna, J Jarjour, S Baxter, SR Roffler, RJ Monnat, BL Stoddard, ... Nucleic acids research 35 (8), 2748-2758, 2007 | 38 | 2007 |
Indirect DNA sequence recognition and its impact on nuclease cleavage activity AR Lambert, JP Hallinan, BW Shen, JK Chik, JM Bolduc, N Kulshina, ... Structure 24 (6), 862-873, 2016 | 28 | 2016 |
A laglidadg homing endonuclease cleaving the cc chemokine receptor type-5 (ccr5) gene and uses thereof J Jarjour, A Astrakhan | 23 | 2014 |
Efficient modification of the CCR5 locus in primary human T cells with megaTAL nuclease establishes HIV-1 resistance GSR Ibarra, B Paul, BD Sather, PM Younan, K Sommer, JP Kowalski, ... Molecular Therapy-Nucleic Acids 5, 2016 | 22 | 2016 |
Multipartite signaling proteins and uses thereof J Jarjour, A Astrakhan, M Certo | 18 | 2015 |
Flow cytometric assays for interrogating LAGLIDADG homing endonuclease DNA-binding and cleavage properties SK Baxter, AR Lambert, AM Scharenberg, J Jarjour Enzyme Engineering: Methods and Protocols, 45-61, 2013 | 17 | 2013 |
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus Y Wang, IF Khan, S Boissel, J Jarjour, J Pangallo, S Thyme, D Baker, ... Nucleic Acids Research 42 (10), 6463-6475, 2014 | 13 | 2014 |
LAGLIDADG homing endonuclease cleaving the T cell receptor alpha gene and uses thereof J Jarjour, A Astrakhan US Patent 10,000,746, 2018 | 12 | 2018 |