Francisca Vazquez
Francisca Vazquez
Director, Cancer Dependency Map, Broad Institute
Verified email at
Cited by
Cited by
Next-generation characterization of the cancer cell line encyclopedia
M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ...
Nature 569 (7757), 503-508, 2019
Defining a cancer dependency map
A Tsherniak, F Vazquez, PG Montgomery, BA Weir, G Kryukov, ...
Cell 170 (3), 564-576. e16, 2017
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells
RM Meyers, JG Bryan, JM McFarland, BA Weir, AE Sizemore, H Xu, ...
Nature genetics 49 (12), 1779-1784, 2017
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
J Rosenbluh, D Nijhawan, AG Cox, X Li, JT Neal, EJ Schafer, TI Zack, ...
Cell 151 (7), 1457-1473, 2012
Genetic and transcriptional evolution alters cancer cell line drug response
U Ben-David, B Siranosian, G Ha, H Tang, Y Oren, K Hinohara, ...
Nature 560 (7718), 325-330, 2018
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress
F Vazquez, JH Lim, H Chim, K Bhalla, G Girnun, K Pierce, CB Clish, ...
Cancer cell 23 (3), 287-301, 2013
Genomic copy number dictates a gene-independent cell response to CRISPR/Cas9 targeting
AJ Aguirre, RM Meyers, BA Weir, F Vazquez, CZ Zhang, U Ben-David, ...
Cancer discovery 6 (8), 914-929, 2016
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling
SM Corsello, RT Nagari, RD Spangler, J Rossen, M Kocak, JG Bryan, ...
Nature cancer 1 (2), 235-248, 2020
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
GS Cowley, BA Weir, F Vazquez, P Tamayo, JA Scott, S Rusin, ...
Scientific data 1 (1), 1-12, 2014
MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
GV Kryukov, FH Wilson, JR Ruth, J Paulk, A Tsherniak, SE Marlow, ...
Science 351 (6278), 1214-1218, 2016
ARID1B is a specific vulnerability in ARID1A-mutant cancers
KC Helming, X Wang, BG Wilson, F Vazquez, JR Haswell, HE Manchester, ...
Nature medicine 20 (3), 251-254, 2014
The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis
MM Pomerantz, F Li, DY Takeda, R Lenci, A Chonkar, M Chabot, P Cejas, ...
Nature genetics 47 (11), 1346-1351, 2015
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
KH Kim, W Kim, TP Howard, F Vazquez, A Tsherniak, JN Wu, W Wang, ...
Nature medicine 21 (12), 1491-1496, 2015
Mutational processes shape the landscape of TP53 mutations in human cancer
AO Giacomelli, X Yang, RE Lintner, JM McFarland, M Duby, J Kim, ...
Nature genetics 50 (10), 1381-1387, 2018
The landscape of cancer cell line metabolism
H Li, S Ning, M Ghandi, GV Kryukov, S Gopal, A Deik, A Souza, K Pierce, ...
Nature medicine 25 (5), 850-860, 2019
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration
JM McFarland, ZV Ho, G Kugener, JM Dempster, PG Montgomery, ...
Nature communications 9 (1), 4610, 2018
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
EM Chan, T Shibue, JM McFarland, B Gaeta, M Ghandi, N Dumont, ...
Nature 568 (7753), 551-556, 2019
Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression
Y Lee, JE Dominy, YJ Choi, M Jurczak, N Tolliday, JP Camporez, H Chim, ...
Nature 510 (7506), 547-551, 2014
Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation
BG Wilson, KC Helming, X Wang, Y Kim, F Vazquez, Z Jagani, WC Hahn, ...
Molecular and cellular biology, 2014
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry
AD Durbin, MW Zimmerman, NV Dharia, BJ Abraham, AB Iniguez, ...
Nature genetics 50 (9), 1240-1246, 2018
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