Anthony Mancuso
Anthony Mancuso
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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
RJ DeBerardinis, A Mancuso, E Daikhin, I Nissim, M Yudkoff, S Wehrli, ...
Proceedings of the National Academy of Sciences 104 (49), 19345-19350, 2007
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
DR Wise, RJ DeBerardinis, A Mancuso, N Sayed, XY Zhang, HK Pfeiffer, ...
Proceedings of the National Academy of Sciences 105 (48), 18782-18787, 2008
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
P Jiang, W Du, X Wang, A Mancuso, X Gao, M Wu, X Yang
Nature cell biology 13 (3), 310-316, 2011
Fructose-1, 6-bisphosphatase opposes renal carcinoma progression
B Li, B Qiu, DSM Lee, ZE Walton, JD Ochocki, LK Mathew, A Mancuso, ...
Nature 513 (7517), 251-255, 2014
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
P Jiang, W Du, A Mancuso, KE Wellen, X Yang
Nature 493 (7434), 689-693, 2013
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
Y Xiang, ZE Stine, J Xia, Y Lu, RS O’Connor, BJ Altman, AL Hsieh, ...
The Journal of clinical investigation 125 (6), 2293-2306, 2015
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
KE Wellen, C Lu, A Mancuso, JMS Lemons, M Ryczko, JW Dennis, ...
Genes & development 24 (24), 2784-2799, 2010
Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
J Ye, A Mancuso, X Tong, PS Ward, J Fan, JD Rabinowitz, CB Thompson
Proceedings of the National Academy of Sciences 109 (18), 6904-6909, 2012
TAp73 enhances the pentose phosphate pathway and supports cell proliferation
W Du, P Jiang, A Mancuso, A Stonestrom, MD Brewer, AJ Minn, TW Mak, ...
Nature cell biology 15 (8), 991-1000, 2013
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
RM Young, D Ackerman, ZL Quinn, A Mancuso, M Gruber, L Liu, ...
Genes & development 27 (10), 1115-1131, 2013
Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming
F Zhao, A Mancuso, TV Bui, X Tong, JJ Gruber, CR Swider, PV Sanchez, ...
Oncogene 29 (20), 2962-2972, 2010
The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation
X Tong, F Zhao, A Mancuso, JJ Gruber, CB Thompson
Proceedings of the National Academy of Sciences 106 (51), 21660-21665, 2009
The MYC oncogene cooperates with sterol-regulated element-binding protein to regulate lipogenesis essential for neoplastic growth
AM Gouw, K Margulis, NS Liu, SJ Raman, A Mancuso, GG Toal, L Tong, ...
Cell metabolism 30 (3), 556-572. e5, 2019
Examination of primary metabolic pathways in a murine hybridoma with carbon‐13 nuclear magnetic resonance spectroscopy
A Mancuso, ST Sharfstein, SN Tucker, DS Clark, HW Blanch
Biotechnology and bioengineering 44 (5), 563-585, 1994
Quantitative in vivo nuclear magnetic resonance studies of hybridoma metabolism
ST Sharfstein, SN Tucker, A Mancuso, HW Blanch, DS Clark
Biotechnology and bioengineering 43 (11), 1059-1074, 1994
IRE1α RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers
H Xie, CHA Tang, JH Song, A Mancuso, JR Del Valle, J Cao, Y Xiang, ...
The Journal of clinical investigation 128 (4), 1300-1316, 2018
A nuclear magnetic resonance technique for determining hybridoma cell concentration in hollow fiber bioreactors
A Mancuso, EJ Fernandez, HW Blanch, DS Clark
Bio/Technology 8 (12), 1282-1285, 1990
MR spectroscopic imaging and diffusion‐weighted MRI for early detection of kainate‐induced status epilepticus in the rat
T Ebisum, WD Rooney, SH Graham, A Mancuso, MW Weiner, ...
Magnetic resonance in medicine 36 (6), 821-828, 1996
Fructose-1, 6-bisphosphatase 2 inhibits sarcoma progression by restraining mitochondrial biogenesis
P Huangyang, F Li, P Lee, I Nissim, AM Weljie, A Mancuso, B Li, B Keith, ...
Cell metabolism 31 (1), 174-188. e7, 2020
Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism
S Shah, WJ Carriveau, J Li, SL Campbell, PK Kopinski, HW Lim, N Daurio, ...
Oncotarget 7 (28), 43713, 2016
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