| Metabolic control of astrocyte pathogenic activity via cPLA2-MAVS CC Chao, C Gutiérrez-Vázquez, V Rothhammer, L Mayo, MA Wheeler, ... Cell 179 (7), 1483-1498. e22, 2019 | 141 | 2019 |
| Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors VN Lagomarsino, RV Pearse, L Liu, YC Hsieh, MA Fernandez, EA Vinton, ... Neuron 109 (21), 3402-3420. e9, 2021 | 81 | 2021 |
| A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor L Liu, L Ding, M Rovere, MS Wolfe, DJ Selkoe Journal of Cell Biology 218 (2), 644-663, 2019 | 68 | 2019 |
| Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer’s disease S Li, M Jin, L Liu, Y Dang, BL Ostaszewski, DJ Selkoe Acta neuropathologica communications 6, 1-16, 2018 | 61 | 2018 |
| Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals JP Chhatwal, AP Schultz, Y Dang, B Ostaszewski, L Liu, HS Yang, ... Nature communications 11 (1), 6024, 2020 | 54 | 2020 |
| The FAM3 superfamily member ILEI ameliorates Alzheimer’s disease-like pathology by destabilizing the penultimate amyloid-β precursor H Hasegawa, L Liu, I Tooyama, S Murayama, M Nishimura Nature communications 5 (1), 3917, 2014 | 50 | 2014 |
| Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study JP Chhatwal, SA Schultz, E McDade, AP Schultz, L Liu, BJ Hanseeuw, ... The Lancet Neurology 21 (2), 140-152, 2022 | 41* | 2022 |
| Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides L Liu, BM Lauro, MS Wolfe, DJ Selkoe Journal of biological chemistry 296, 2021 | 27 | 2021 |
| Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer’s disease L Liu, N Watanabe, H Akatsu, M Nishimura Neuroscience 330, 236-246, 2016 | 27 | 2016 |
| Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains AM Stern, Y Yang, S Jin, K Yamashita, AL Meunier, W Liu, Y Cai, ... Neuron 111 (13), 2012-2020. e4, 2023 | 25 | 2023 |
| Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease L Liu, BM Lauro, A He, H Lee, S Bhattarai, MS Wolfe, DA Bennett, ... Alzheimer's & Dementia, 2022 | 24 | 2022 |
| Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease L Fonseca-Ornelas, T Viennet, M Rovere, H Jiang, L Liu, S Nuber, ... Cell reports 36 (1), 2021 | 24 | 2021 |
| Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life L Liu, BM Lauro, L Ding, M Rovere, MS Wolfe, DJ Selkoe Alzheimer's & Dementia 15 (9), 1183-1194, 2019 | 23 | 2019 |
| Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity N Ramalingam, SX Jin, TE Moors, L Fonseca-Ornelas, K Shimanaka, ... npj Parkinson's Disease 9 (1), 4, 2023 | 21 | 2023 |
| An ultra‐sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma L Liu, H Kwak, TL Lawton, SX Jin, AL Meunier, Y Dang, B Ostaszewski, ... Alzheimer's & Dementia 18 (6), 1186-1202, 2022 | 21 | 2022 |
| Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations L De Boni, AH Watson, L Zaccagnini, A Wallis, K Zhelcheska, N Kim, ... Acta Neuropathologica 143 (4), 453-469, 2022 | 17 | 2022 |
| Dilysine retrieval signal‐containing p24 proteins collaborate in inhibiting γ‐cleavage of amyloid precursor protein H Hasegawa, L Liu, M Nishimura Journal of neurochemistry 115 (3), 771-781, 2010 | 17 | 2010 |
| Age‐related modulation of γ‐secretase activity in non‐human primate brains M Nishimura, S Nakamura, N Kimura, L Liu, T Suzuki, I Tooyama Journal of neurochemistry 123 (1), 21-28, 2012 | 15 | 2012 |
| Aβ oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this SX Jin, L Liu, S Li, AL Meunier, DJ Selkoe Neurobiology of disease 172, 105816, 2022 | 9 | 2022 |
| Pathogenic mechanisms of cytosolic and membrane-enriched α-synuclein converge on fatty acid homeostasis A Tripathi, H Alnakhala, E Terry-Kantor, A Newman, L Liu, T Imberdis, ... Journal of Neuroscience 42 (10), 2116-2130, 2022 | 9 | 2022 |
Hiroyasu AkatsuProfessor of community-based Medical Education, Nagoya City UniversityVerified email at chojuken.net
