Akira Kobayashi
Akira Kobayashi
Professor of Molecular Biology, Doshisha University
Verified email at - Homepage
Cited by
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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
A Kobayashi, MI Kang, H Okawa, M Ohtsuji, Y Zenke, T Chiba, K Igarashi, ...
Molecular and cellular biology 24 (16), 7130-7139, 2004
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
M Komatsu, S Waguri, M Koike, Y Sou, T Ueno, T Hara, N Mizushima, ...
Cell 131 (6), 1149-1163, 2007
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
M Komatsu, H Kurokawa, S Waguri, K Taguchi, A Kobayashi, Y Ichimura, ...
Nature cell biology 12 (3), 213-223, 2010
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers
N Wakabayashi, AT Dinkova-Kostova, WD Holtzclaw, MI Kang, ...
Proceedings of the National Academy of Sciences 101 (7), 2040-2045, 2004
Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1
A Kobayashi, MI Kang, Y Watai, KI Tong, T Shibata, K Uchida, ...
Molecular and cellular biology 26 (1), 221-229, 2006
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
B Padmanabhan, KI Tong, T Ohta, Y Nakamura, M Scharlock, M Ohtsuji, ...
Molecular cell 21 (5), 689-700, 2006
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
T Ohta, K Iijima, M Miyamoto, I Nakahara, H Tanaka, M Ohtsuji, T Suzuki, ...
Cancer research 68 (5), 1303-1309, 2008
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes
MI Kang, A Kobayashi, N Wakabayashi, SG Kim, M Yamamoto
Proceedings of the National Academy of Sciences 101 (7), 2046-2051, 2004
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
Y Katoh, K Itoh, E Yoshida, M Miyagishi, A Fukamizu, M Yamamoto
Genes to Cells 6 (10), 857-868, 2001
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity
T Yamamoto, T Suzuki, A Kobayashi, J Wakabayashi, J Maher, ...
Molecular and cellular biology 28 (8), 2758-2770, 2008
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism
KI Tong, A Kobayashi, F Katsuoka, M Yamamoto
Walter de Gruyter 387 (10_11), 1311-1320, 2006
Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
KI Tong, B Padmanabhan, A Kobayashi, C Shang, Y Hirotsu, S Yokoyama, ...
Molecular and cellular biology 27 (21), 7511-7521, 2007
Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity
H Okawa, H Motohashi, A Kobayashi, H Aburatani, TW Kensler, ...
Biochemical and biophysical research communications 339 (1), 79-88, 2006
Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P‐4501A1 gene.
H Imataka, K Sogawa, KI Yasumoto, Y Kikuchi, K Sasano, A Kobayashi, ...
The EMBO journal 11 (10), 3663-3671, 1992
Carnosic acid, a catechol‐type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S‐alkylation of …
T Satoh, K Kosaka, K Itoh, A Kobayashi, M Yamamoto, Y Shimojo, ...
Journal of neurochemistry 104 (4), 1116-1131, 2008
Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
M Ohtsuji, F Katsuoka, A Kobayashi, H Aburatani, JD Hayes, ...
Journal of Biological Chemistry 283 (48), 33554-33562, 2008
Molecular cloning and functional characterization of a new Cap'n'collar family transcription factor Nrf3
A Kobayashi, E Ito, T Toki, K Kogame, S Takahashi, K Igarashi, N Hayashi, ...
Journal of Biological Chemistry 274 (10), 6443-6452, 1999
Protein S-guanylation by the biological signal 8-nitroguanosine 3′, 5′-cyclic monophosphate
T Sawa, MH Zaki, T Okamoto, T Akuta, Y Tokutomi, S Kim-Mitsuyama, ...
Nature chemical biology 3 (11), 727-735, 2007
Unique function of the Nrf2–Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes
A Kobayashi, T Ohta, M Yamamoto
Methods in enzymology 378, 273-286, 2004
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome
Y Katoh, K Iida, MIL Kang, A Kobayashi, M Mizukami, KI Tong, ...
Archives of biochemistry and biophysics 433 (2), 342-350, 2005
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