| A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline T Jonsson, JK Atwal, S Steinberg, J Snaedal, PV Jonsson, S Bjornsson, ... Nature 488 (7409), 96-99, 2012 | 2097 | 2012 |
| Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index JR Junutula, H Raab, S Clark, S Bhakta, DD Leipold, S Weir, Y Chen, ... Nature biotechnology 26 (8), 925-932, 2008 | 1449 | 2008 |
| Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target YJ Yu, Y Zhang, M Kenrick, K Hoyte, W Luk, Y Lu, J Atwal, JM Elliott, ... Science translational medicine 3 (84), 84ra44-84ra44, 2011 | 788 | 2011 |
| Importance of cellular microenvironment and circulatory dynamics in B cell immunotherapy Q Gong, Q Ou, S Ye, WP Lee, J Cornelius, L Diehl, WY Lin, Z Hu, Y Lu, ... The Journal of Immunology 174 (2), 817-826, 2005 | 631 | 2005 |
| Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates YJ Yu, JK Atwal, Y Zhang, RK Tong, KR Wildsmith, C Tan, N Bien-Ly, ... Science translational medicine 6 (261), 261ra154-261ra154, 2014 | 365 | 2014 |
| An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells NS Wilson, B Yang, A Yang, S Loeser, S Marsters, D Lawrence, Y Li, ... Cancer cell 19 (1), 101-113, 2011 | 340 | 2011 |
| Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants N Bien-Ly, YJ Yu, D Bumbaca, J Elstrott, CA Boswell, Y Zhang, W Luk, ... Journal of Experimental Medicine 211 (2), 233-244, 2014 | 324 | 2014 |
| A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo JK Atwal, Y Chen, C Chiu, DL Mortensen, WJ Meilandt, Y Liu, CE Heise, ... Science translational medicine 3 (84), 84ra43-84ra43, 2011 | 299 | 2011 |
| Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer TT Junttila, K Parsons, C Olsson, Y Lu, Y Xin, J Theriault, L Crocker, ... Cancer research 70 (11), 4481-4489, 2010 | 292 | 2010 |
| Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier JA Couch, YJ Yu, Y Zhang, JM Tarrant, RN Fuji, WJ Meilandt, H Solanoy, ... Science translational medicine 5 (183), 183ra57-183ra57, 2013 | 259 | 2013 |
| Discovery of novel blood-brain barrier targets to enhance brain uptake of therapeutic antibodies YJY Zuchero, X Chen, N Bien-Ly, D Bumbaca, RK Tong, X Gao, S Zhang, ... Neuron 89 (1), 70-82, 2016 | 252 | 2016 |
| Lack of widespread BBB disruption in Alzheimer’s disease models: focus on therapeutic antibodies N Bien-Ly, CA Boswell, S Jeet, TG Beach, K Hoyte, W Luk, V Shihadeh, ... Neuron 88 (2), 289-297, 2015 | 189 | 2015 |
| Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling J Jackman, Y Chen, A Huang, B Moffat, JM Scheer, SR Leong, WP Lee, ... Journal of biological chemistry 285 (27), 20850-20859, 2010 | 122 | 2010 |
| Antibody-mediated targeting of tau in vivo does not require effector function and microglial engagement SH Lee, CE Le Pichon, O Adolfsson, V Gafner, M Pihlgren, H Lin, ... Cell reports 16 (6), 1690-1700, 2016 | 119 | 2016 |
| Retinoblastoma protein inhibits IFN-gamma induced apoptosis. DE Berry, Y Lu, B Schmidt, PG Fallon, C O'Connell, SX Hu, HJ Xu, ... Oncogene 12 (8), 1809-1819, 1996 | 100 | 1996 |
| NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway Y Lu, J Brush, TA Stewart Journal of Biological Chemistry 274 (15), 10047-10052, 1999 | 99 | 1999 |
| Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice R Deng, YG Meng, K Hoyte, J Lutman, Y Lu, S Iyer, LE DeForge, FP Theil, ... MAbs 4 (1), 101-109, 2012 | 72 | 2012 |
| Evidence for retinoblastoma protein (RB) dependent and independent IFN-gamma responses: RB coordinately rescues IFN-gamma induction of MHC class II gene transcription in … Y Lu, GD Ussery, MM Muncaster, BL Gallie, G Blanck Oncogene 9 (4), 1015-1019, 1994 | 66 | 1994 |
| Multidimensional biodata integration and relationship inference K Qu, N Lin, Y Lu, DG Payan US Patent 7,243,112, 2007 | 65 | 2007 |
| Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer’s disease G Ayalon, SH Lee, O Adolfsson, C Foo-Atkins, JK Atwal, M Blendstrup, ... Science Translational Medicine 13 (593), eabb2639, 2021 | 58 | 2021 |
