| Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli BA Pfeifer, SJ Admiraal, H Gramajo, DE Cane, C Khosla Science 291 (5509), 1790-1792, 2001 | 974 | 2001 |
| Harnessing the biosynthetic code: combinations, permutations, and mutations DE Cane, CT Walsh, C Khosla Science 282 (5386), 63-68, 1998 | 885 | 1998 |
| Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism M Komatsu, T Uchiyama, S Ōmura, DE Cane, H Ikeda Proceedings of the National Academy of Sciences 107 (6), 2646-2651, 2010 | 630 | 2010 |
| Enzymic formation of sesquiterpenes DE Cane Chemical Reviews 90 (7), 1089-1103, 1990 | 612 | 1990 |
| Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology CA Lesburg, G Zhai, DE Cane, DW Christianson Science 277 (5333), 1820-1824, 1997 | 530 | 1997 |
| Terpene synthases are widely distributed in bacteria Y Yamada, T Kuzuyama, M Komatsu, K Shin-Ya, S Omura, DE Cane, ... Proceedings of the National Academy of Sciences 112 (3), 857-862, 2015 | 506 | 2015 |
| Tolerance and specificity of polyketide synthases C Khosla, RS Gokhale, JR Jacobsen, DE Cane Annual review of biochemistry 68 (1), 219-253, 1999 | 481 | 1999 |
| Dissecting and exploiting intermodular communication in polyketide synthases RS Gokhale, SY Tsuji, DE Cane, C Khosla Science 284 (5413), 482-485, 1999 | 441 | 1999 |
| The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases DE Cane, CT Walsh Chemistry & biology 6 (12), R319-R325, 1999 | 421 | 1999 |
| Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase JR Jacobsen, CR Hutchinson, DE Cane, C Khosla Science 277 (5324), 367-369, 1997 | 391 | 1997 |
| Structure and mechanism of the 6-deoxyerythronolide B synthase C Khosla, Y Tang, AY Chen, NA Schnarr, DE Cane Annu. Rev. Biochem. 76 (1), 195-221, 2007 | 365 | 2007 |
| The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase Y Tang, CY Kim, II Mathews, DE Cane, C Khosla Proceedings of the National Academy of Sciences 103 (30), 11124-11129, 2006 | 354 | 2006 |
| Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade MJ Rynkiewicz, DE Cane, DW Christianson Proceedings of the National Academy of Sciences 98 (24), 13543-13548, 2001 | 317 | 2001 |
| Unified stereochemical model of polyether antibiotic structure and biogenesis DE Cane, WD Celmer, JW Westley Journal of the American Chemical Society 105 (11), 3594-3600, 1983 | 307 | 1983 |
| Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme J Jiang, X He, DE Cane Nature Chemical Biology 3 (11), 711-715, 2007 | 299 | 2007 |
| Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites M Komatsu, K Komatsu, H Koiwai, Y Yamada, I Kozone, M Izumikawa, ... ACS synthetic biology 2 (7), 384-396, 2013 | 283 | 2013 |
| Sesquiterpene biosynthesis: cyclization mechanisms DE Cane Comprehensive natural products chemistry 2, 155-200, 1999 | 283* | 1999 |
| Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel SC Tsai, LJW Miercke, J Krucinski, R Gokhale, JCH Chen, PG Foster, ... Proceedings of the National Academy of Sciences 98 (26), 14808-14813, 2001 | 274 | 2001 |
| Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase CM Kao, G Luo, L Katz, DE Cane, C Khosla Journal of the American Chemical Society 117 (35), 9105-9106, 1995 | 252 | 1995 |
| Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase RS Gokhale, D Hunziker, DE Cane, C Khosla Chemistry & biology 6 (2), 117-125, 1999 | 220 | 1999 |
