Sim Taebo
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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
CC Thoreen, SA Kang, JW Chang, Q Liu, J Zhang, Y Gao, LJ Reichling, ...
Journal of Biological Chemistry 284 (12), 8023-8032, 2009
Targeting transcription regulation in cancer with a covalent CDK7 inhibitor
N Kwiatkowski, T Zhang, PB Rahl, BJ Abraham, J Reddy, SB Ficarro, ...
Nature 511 (7511), 616-620, 2014
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
J Zhang, FJ Adrián, W Jahnke, SW Cowan-Jacob, AG Li, RE Iacob, T Sim, ...
Nature 463 (7280), 501-506, 2010
Allosteric inhibitors of Bcr-abl–dependent cell proliferation
FJ Adrián, Q Ding, T Sim, A Velentza, C Sloan, Y Liu, G Zhang, W Hur, ...
Nature chemical biology 2 (2), 95-102, 2006
Discovery of potent and selective covalent inhibitors of JNK
T Zhang, F Inesta-Vaquera, M Niepel, J Zhang, SB Ficarro, T Machleidt, ...
Chemistry & biology 19 (1), 140-154, 2012
Therapeutic targeting of oncogenic K‐Ras by a covalent catalytic site inhibitor
SM Lim, KD Westover, SB Ficarro, RA Harrison, HG Choi, ME Pacold, ...
Angewandte Chemie 126 (1), 203-208, 2014
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function
N Kwiatkowski, N Jelluma, P Filippakopoulos, M Soundararajan, ...
Nature chemical biology 6 (5), 359-368, 2010
Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective …
Q Liu, JW Chang, J Wang, SA Kang, CC Thoreen, A Markhard, W Hur, ...
Journal of medicinal chemistry 53 (19), 7146-7155, 2010
A general strategy for creating “inactive-conformation” abl inhibitors
B Okram, A Nagle, FJ Adrián, C Lee, P Ren, X Wang, T Sim, Y Xie, ...
Chemistry & biology 13 (7), 779-786, 2006
Test systems for harmonics modeling and simulation
R Abu-Hashim, R Burch, G Chang, M Grady, E Gunther, M Halpin, ...
IEEE Transactions on Power Delivery 14 (2), 579-587, 1999
Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors
L Tan, J Wang, J Tanizaki, Z Huang, AR Aref, M Rusan, SJ Zhu, Y Zhang, ...
Proceedings of the National Academy of Sciences 111 (45), E4869-E4877, 2014
Pharmacological targeting of the pseudokinase Her3
T Xie, SM Lim, KD Westover, ME Dodge, D Ercan, SB Ficarro, ...
Nature chemical biology 10 (12), 1006-1012, 2014
Efficient Synthesis of Enantiomerically Pure 2-Acylaziridines:  Facile Syntheses of N-Boc-safingol, N-Boc-d-erythro-sphinganine, and N-Boc-spisulosine from a …
JM Yun, TB Sim, HS Hahm, WK Lee, HJ Ha
The Journal of organic chemistry 68 (20), 7675-7680, 2003
Novel compounds and compositions as protein kinase inhibitors
Q Ding, T Sim, G Zhang, F Adrian, N Gray
US Patent App. 10/817,328, 2005
Tools for target identification and validation
S Wang, TB Sim, YS Kim, YT Chang
Current opinion in chemical biology 8 (4), 371-377, 2004
Compounds and compositions as protein kinase inhibitors
Q Ding, NS Gray, B Li, Y Liu, T Sim, T Uno, G Zhang, CP Soldermann, ...
US Patent 8,552,002, 2013
A Novel Synthesis of 5-Functionalized Oxazolidin-2-ones from Enantiomerically Pure 2-Substituted N-[(R)-(+)-α-Methylbenzyl]aziridines
TB Sim, SH Kang, KS Lee, WK Lee, H Yun, Y Dong, HJ Ha
The Journal of organic chemistry 68 (1), 104-108, 2003
Acquired METD1228V mutation and resistance to MET inhibition in lung cancer
M Bahcall, T Sim, CP Paweletz, JD Patel, RS Alden, Y Kuang, AG Sacher, ...
Cancer discovery 6 (12), 1334-1341, 2016
Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRα, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants
E Weisberg, HG Choi, A Ray, R Barrett, J Zhang, T Sim, W Zhou, ...
Blood, The Journal of the American Society of Hematology 115 (21), 4206-4216, 2010
Novel stereoselective synthesis of functionalized oxazolidinones from chiral aziridines
CS Park, MS Kim, TB Sim, DK Pyun, CH Lee, D Choi, WK Lee, JW Chang, ...
The Journal of organic chemistry 68 (1), 43-49, 2003
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