David M. Virshup

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Babita MadanAssistant Professor at Duke-NUS Medical SchoolVerified email at duke-nus.edu.sg
Jit Kong CheongResearch Assistant Professor, Yong Loo Lin School of Medicine, NUSVerified email at nus.edu.sg
Nathan HarmstonCardiff UniversityVerified email at cardiff.ac.uk
Jia YuSenior Research Fellow, Duke-NUS Medical SchoolVerified email at duke-nus.edu.sg
Gary CoombsProfessor of Biology, Waldorf UniversityVerified email at waldorf.edu
Rajesh NarasimamurthyPrincipal research scientist, Duke-NUS medical school, SingaporeVerified email at duke-nus.edu.sg
Daniel ForgerUniversity of MichiganVerified email at umich.edu
Enrico PetrettoAssoc. Professor & Director @ Centre for Computational Biology of Duke-NUS Medical School, SingaporeVerified email at duke-nus.edu.sg
Zahra Kabiri, MD, PhDAssistant Professor, Duke UniversityVerified email at duke.edu
Tracy M. CoveyProfessor of Chemistry, Weber State UniversityVerified email at weber.edu
Alex MatterCEO, AtumRa Therapeutics Pte Ltd., SingaporeVerified email at atumratx.com
Simran KaurMcGill Goodman Cancer Research CenterVerified email at mail.mcgill.ca
Sang Hyun LeeDuke-NUS Graduate Medical School SingaporeVerified email at duke-nus.edu.sg
Jae Kyoung KimAssoc. Professor, Mathematical Sciences, KAIST & Chief Investigator, Biomedical Mathematics GroupVerified email at kaist.ac.kr
Bart O. WilliamsVan Andel Research InstituteVerified email at vai.org
Rami N Hannoush, Ph.D.Genentech, McGill, Harvard, Versant VenturesVerified email at post.harvard.edu
Marian L. WatermanProfessor, Department of Microbiology and Molecular GeneticsVerified email at uci.edu
Ruby Huang Yun-JuProfessor, School of Medicine, National Taiwan UniversityVerified email at ntu.edu.tw
Steven G. RozenDuke-NUS Medical School SingaporeVerified email at duke-nus.edu.sg
Joseph S. TakahashiDepartment of Neuroscience, Howard Hughes Medical Institute, University of Texas SouthwesternVerified email at utsouthwestern.edu

David M. Virshup

Duke-NUS Medical School Singapore

Verified email at duke-nus.edu.sg

Casein Kinase 1 protein phosphatases Wnt signaling circadian rhythms


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An hPer2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome KL Toh, CR Jones, Y He, EJ Eide, WA Hinz, DM Virshup, LJ Ptácek, ... Science 291 (5506), 1040-1043, 2001	1745	2001
Post-translational modifications regulate the ticking of the circadian clock M Gallego, DM Virshup Nature reviews Molecular cell biology 8 (2), 139-148, 2007	952	2007
From promiscuity to precision: protein phosphatases get a makeover DM Virshup, S Shenolikar Molecular cell 33 (5), 537-545, 2009	719	2009
Control of mammalian circadian rhythm by CKIε-regulated proteasome-mediated PER2 degradation EJ Eide, MF Woolf, H Kang, P Woolf, W Hurst, F Camacho, EL Vielhaber, ... Molecular and cellular biology 25 (7), 2795-2807, 2005	596	2005
Regulation of β-catenin signaling by the B56 subunit of protein phosphatase 2A JM Seeling, JR Miller, R Gil, RT Moon, R White, DM Virshup Science 283 (5410), 2089-2091, 1999	591	1999
The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm B McCright, AM Rivers, S Audlin, DM Virshup Journal of Biological Chemistry 271 (36), 22081-22089, 1996	478	1996
Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I ɛ E Vielhaber, E Eide, A Rivers, ZH Gao, DM Virshup Molecular and cellular biology 20 (13), 4888-4899, 2000	433	2000
Protein phosphatase 2A: a panoply of enzymes DM Virshup Current opinion in cell biology 12 (2), 180-185, 2000	423	2000
The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iε EJ Eide, EL Vielhaber, WA Hinz, DM Virshup Journal of Biological Chemistry 277 (19), 17248-17254, 2002	416	2002
Setting clock speed in mammals: the CK1ɛ tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins QJ Meng, L Logunova, ES Maywood, M Gallego, J Lebiecki, TM Brown, ... Neuron 58 (1), 78-88, 2008	410	2008
Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer KD Proffitt, B Madan, Z Ke, V Pendharkar, L Ding, MA Lee, RN Hannoush, ... Cancer research 73 (2), 502-507, 2013	376	2013
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts Z Kabiri, G Greicius, B Madan, S Biechele, Z Zhong, H Zaribafzadeh, ... Development 141 (11), 2206-2215, 2014	332	2014
Identification of cellular proteins required for simian virus 40 DNA replication MS Wold, DH Weinberg, DM Virshup, JJ Li, TJ Kelly Journal of Biological Chemistry 264 (5), 2801-2809, 1989	306	1989
Identification of a new family of protein phosphatase 2A regulatory subunits (∗) B McCright, DM Virshup Journal of Biological Chemistry 270 (44), 26123-26128, 1995	302	1995
Wnt addiction of genetically defined cancers reversed by PORCN inhibition B Madan, Z Ke, N Harmston, SY Ho, AO Frois, J Alam, DA Jeyaraj, ... Oncogene 35 (17), 2197-2207, 2016	299	2016
Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex ZH Gao, JM Seeling, V Hill, A Yochum, DM Virshup Proceedings of the National Academy of Sciences 99 (3), 1182-1187, 2002	298	2002
Casein kinase 1: Complexity in the family JK Cheong, DM Virshup The international journal of biochemistry & cell biology 43 (4), 465-469, 2011	267	2011
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1 H Okamura, C Garcia-Rodriguez, H Martinson, J Qin, DM Virshup, A Rao Molecular and cellular biology 24 (10), 4184-4195, 2004	257	2004
PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo G Greicius, Z Kabiri, K Sigmundsson, C Liang, R Bunte, MK Singh, ... Proceedings of the National Academy of Sciences 115 (14), E3173-E3181, 2018	255	2018
Role for the PP2A/B56δ phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis SS Margolis, JA Perry, CM Forester, LK Nutt, Y Guo, MJ Jardim, ... Cell 127 (4), 759-773, 2006	250	2006

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