| Reductive carboxylation supports growth in tumour cells with defective mitochondria AR Mullen, WW Wheaton, ES Jin, PH Chen, LB Sullivan, T Cheng, ... Nature 481 (7381), 385-388, 2012 | 1392 | 2012 |
| Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis WW Wheaton, SE Weinberg, RB Hamanaka, S Soberanes, LB Sullivan, ... elife 3, e02242, 2014 | 1117 | 2014 |
| Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells LB Sullivan, DY Gui, AM Hosios, LN Bush, E Freinkman, ... Cell 162 (3), 552-563, 2015 | 1063 | 2015 |
| Mitochondrial reactive oxygen species and cancer LB Sullivan, NS Chandel Cancer & metabolism 2, 1-12, 2014 | 804 | 2014 |
| Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer SM Davidson, T Papagiannakopoulos, BA Olenchock, JE Heyman, ... Cell metabolism 23 (3), 517-528, 2016 | 696 | 2016 |
| A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate ME Pacold, KR Brimacombe, SH Chan, JM Rohde, CA Lewis, ... Nature chemical biology 12 (6), 452-458, 2016 | 465 | 2016 |
| Altered metabolite levels in cancer: implications for tumour biology and cancer therapy LB Sullivan, DY Gui, MGV Heiden Nature Reviews Cancer 16 (11), 680-693, 2016 | 369 | 2016 |
| Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects AR Mullen, Z Hu, X Shi, L Jiang, LK Boroughs, Z Kovacs, R Boriack, ... Cell reports 7 (5), 1679-1690, 2014 | 354 | 2014 |
| Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin DY Gui, LB Sullivan, A Luengo, AM Hosios, LN Bush, N Gitego, ... Cell metabolism 24 (5), 716-727, 2016 | 321 | 2016 |
| The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling LB Sullivan, E Martinez-Garcia, H Nguyen, AR Mullen, E Dufour, ... Molecular cell 51 (2), 236-248, 2013 | 308 | 2013 |
| Aspartate is an endogenous metabolic limitation for tumour growth LB Sullivan, A Luengo, LV Danai, LN Bush, FF Diehl, AM Hosios, AN Lau, ... Nature cell biology 20 (7), 782-788, 2018 | 287 | 2018 |
| Increased demand for NAD+ relative to ATP drives aerobic glycolysis A Luengo, Z Li, DY Gui, LB Sullivan, M Zagorulya, BT Do, R Ferreira, ... Molecular cell 81 (4), 691-707. e6, 2021 | 285 | 2021 |
| EGLN1 inhibition and rerouting of α-ketoglutarate suffice for remote ischemic protection BA Olenchock, J Moslehi, AH Baik, SM Davidson, J Williams, WJ Gibson, ... Cell 164 (5), 884-895, 2016 | 144 | 2016 |
| A non-canonical tricarboxylic acid cycle underlies cellular identity PK Arnold, BT Jackson, KI Paras, JS Brunner, ML Hart, OJ Newsom, ... Nature 603 (7901), 477-481, 2022 | 121 | 2022 |
| Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy A Luengo, LB Sullivan, MGV Heiden BMC biology 12, 1-4, 2014 | 116 | 2014 |
| MAX functions as a tumor suppressor and rewires metabolism in small cell lung cancer A Augert, H Mathsyaraja, AH Ibrahim, B Freie, MJ Geuenich, PF Cheng, ... Cancer cell 38 (1), 97-114. e7, 2020 | 54 | 2020 |
| Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy CA McLellan, BM Vincent, NV Solis, AK Lancaster, LB Sullivan, ... Nature chemical biology 14 (2), 135-141, 2018 | 35 | 2018 |
| Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells SB Crist, T Nemkov, RF Dumpit, J Dai, SJ Tapscott, LD True, A Swarbrick, ... Nature Cell Biology 24 (4), 538-553, 2022 | 28 | 2022 |
| Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis MP Rossmann, K Hoi, V Chan, BJ Abraham, S Yang, J Mullahoo, ... Science 372 (6543), 716-721, 2021 | 28 | 2021 |
| MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme Y Li, NA Ivica, T Dong, DP Papageorgiou, Y He, DR Brown, M Kleyman, ... Nature communications 11 (1), 4837, 2020 | 28 | 2020 |
Navdeep ChandelProfessor of Medicine, Biochemistry and Molecular Genetics, Northwestern UniversityVerified email at northwestern.edu
