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Luke McAlary
Luke McAlary
Verified email at uow.edu.au
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Year
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins
V Deora, JD Lee, EA Albornoz, L McAlary, CJ Jagaraj, AAB Robertson, ...
Glia 68 (2), 407-421, 2020
1562020
Prion-like propagation of protein misfolding and aggregation in amyotrophic lateral sclerosis
L McAlary, SS Plotkin, JJ Yerbury, NR Cashman
Frontiers in molecular neuroscience 12, 262, 2019
1322019
CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1) G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1
JM Silverman, D Christy, CC Shyu, KM Moon, S Fernando, Z Gidden, ...
Journal of Biological Chemistry 294 (10), 3744-3759, 2019
1232019
Susceptibility of mutant SOD1 to form a destabilized monomer predicts cellular aggregation and toxicity but not in vitro aggregation propensity
L McAlary, JA Aquilina, JJ Yerbury
Frontiers in neuroscience 10, 231906, 2016
922016
The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation
MJ Capper, GSA Wright, L Barbieri, E Luchinat, E Mercatelli, L McAlary, ...
Nature communications 9 (1), 1693, 2018
882018
Proteome homeostasis dysfunction: a unifying principle in ALS pathogenesis
JJ Yerbury, NE Farrawell, L McAlary
Trends in Neurosciences 43 (5), 274-284, 2020
542020
Glutathionylation potentiates benign superoxide dismutase 1 variants to the toxic forms associated with amyotrophic lateral sclerosis
L McAlary, JJ Yerbury, JA Aquilina
Scientific reports 3 (1), 3275, 2013
532013
SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS
NE Farrawell, I Lambert-Smith, K Mitchell, J McKenna, L McAlary, ...
Journal of cell science 131 (11), jcs209122, 2018
462018
Tryptophan 32-mediated SOD1 aggregation is attenuated by pyrimidine-like compounds in living cells
E Pokrishevsky, L McAlary, N Farrawell, B Zhao, M Sher, JJ Yerbury, ...
Scientific Reports 8, 2018
422018
Rapid flow cytometric measurement of protein inclusions and nuclear trafficking
DR Whiten, R San Gil, L McAlary, JJ Yerbury, H Ecroyd, MR Wilson
Scientific Reports 6 (1), 31138, 2016
342016
Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E
J Robert, EB Button, EM Martin, L McAlary, Z Gidden, M Gilmour, G Boyce, ...
Molecular neurodegeneration 15, 1-21, 2020
302020
Amyotrophic lateral sclerosis: proteins, proteostasis, prions, and promises
L McAlary, YL Chew, JS Lum, NJ Geraghty, JJ Yerbury, NR Cashman
Frontiers in Cellular Neuroscience 14, 581907, 2020
302020
Flow cytometric measurement of the cellular propagation of TDP-43 aggregation
R Zeineddine, DR Whiten, NE Farrawell, L McAlary, MA Hanspal, ...
Prion 11 (3), 195-204, 2017
302017
Ubiquitin homeostasis is disrupted in TDP-43 and FUS cell models of ALS
NE Farrawell, L McAlary, JS Lum, CG Chisholm, ST Warraich, IP Blair, ...
Iscience 23 (11), 2020
292020
Emerging developments in targeting proteotoxicity in neurodegenerative diseases
L McAlary, SS Plotkin, NR Cashman
CNS drugs 33 (9), 883-904, 2019
262019
The prion-like nature of amyotrophic lateral sclerosis
L McAlary, JJ Yerbury, NR Cashman
Progress in Molecular Biology and Translational Science 175, 261-296, 2020
222020
Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection
A Crown, L McAlary, E Fagerli, H Brown, JJ Yerbury, A Galaleldeen, ...
PloS one 15 (1), e0227655, 2020
202020
CuATSM Protects Against the In Vitro Cytotoxicity of Wild-Type-Like Copper–Zinc Superoxide Dismutase Mutants but not Mutants That Disrupt Metal Binding
NE Farrawell, MR Yerbury, SS Plotkin, L McAlary, JJ Yerbury
ACS chemical neuroscience 10 (3), 1555-1564, 2018
192018
Trajectory taken by dimeric Cu/Zn superoxide dismutase through the protein unfolding and dissociation landscape is modulated by salt bridge formation
L McAlary, JA Harrison, JA Aquilina, SP Fitzgerald, C Kelso, JLP Benesch, ...
Analytical chemistry 92 (2), 1702-1711, 2019
122019
A copper chaperone–mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis
L McAlary, VK Shephard, GSA Wright, JJ Yerbury
Journal of Biological Chemistry 298 (3), 2022
112022
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