|A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease|
M Bj÷rkqvist, EJ Wild, J Thiele, A Silvestroni, R Andre, N Lahiri, E Raibon, ...
Journal of Experimental Medicine 205 (8), 1869-1877, 2008
|Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity|
W Song, J Chen, A Petrilli, G Liot, E Klinglmayr, Y Zhou, P Poquiz, J Tjong, ...
Nature medicine 17 (3), 377-382, 2011
|Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice|
AJ Milnerwood, CM Gladding, MA Pouladi, AM Kaufman, RM Hines, ...
Neuron 65 (2), 178-190, 2010
|Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin|
S Okamoto*, MA Pouladi*, M Talantova*, D Yao*, P Xia, DE Ehrnhoefer, ...
Nature medicine 15 (12), 1407-1413, 2009
|Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtiná…|
A Kuhn, DR Goldstein, A Hodges, AD Strand, T Sengstag, C Kooperberg, ...
Human molecular genetics 16 (15), 1845-1861, 2007
|Choosing an animal model for the study of Huntington's disease|
MA Pouladi, AJ Morton, MR Hayden
Nature Reviews Neuroscience 14 (10), 708-721, 2013
|Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness|
CS Robbins, DE Dawe, SI Goncharova, MA Pouladi, AG Drannik, ...
American journal of respiratory cell and molecular biology 30 (2), 202-211, 2004
|Impact of Cigarette Smoke on Clearance and Inflammation after Pseudomonas aeruginosa Infection|
AG Drannik, MA Pouladi, CS Robbins, SI Goncharova, S Kianpour, ...
American journal of respiratory and critical care medicine 170 (11), 1164-1171, 2004
|Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function|
K Takata, T Kozaki, CZW Lee, MS Thion, M Otsuka, S Lim, KH Utami, ...
Immunity 47 (1), 183-198. e6, 2017
|Inhibition of phosphatidylinositol-4-phosphate 5-kinase Iα impairs localized actin remodeling and suppresses phagocytosis|
MG Coppolino, R Dierckman, J Loijens, RF Collins, M Pouladi, ...
Journal of Biological Chemistry 277 (46), 43849-43857, 2002
|Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin|
MA Pouladi, RK Graham, JM Karasinska, Y Xie, RD Santos, ┼ PetersÚn, ...
Brain 132 (4), 919-932, 2009
|Reversal of phenotypic abnormalities by CRISPR/Cas9-mediated gene correction in Huntington disease patient-derived induced pluripotent stem cells|
X Xu, Y Tay, B Sim, SI Yoon, Y Huang, J Ooi, KH Utami, A Ziaei, B Ng, ...
Stem cell reports 8 (3), 619-633, 2017
|Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice|
MA Pouladi, LM Stanek, Y Xie, S Franciosi, AL Southwell, Y Deng, ...
Human molecular genetics 21 (10), 2219-2232, 2012
|Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes|
M Valenza, V Leoni, JM Karasinska, L Petricca, J Fan, J Carroll, ...
Journal of Neuroscience 30 (32), 10844-10850, 2010
|Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease|
RK Graham, MA Pouladi, P Joshi, G Lu, Y Deng, NP Wu, BE Figueroa, ...
Journal of Neuroscience 29 (7), 2193-2204, 2009
|Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo|
RK Graham, Y Deng, J Carroll, K Vaid, C Cowan, MA Pouladi, M Metzler, ...
Journal of Neuroscience 30 (45), 15019-15029, 2010
|Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis|
K Becanovic, MA Pouladi, RS Lim, A Kuhn, P Pavlidis, R Luthi-Carter, ...
Human molecular genetics 19 (8), 1438-1452, 2010
|Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression|
MA Pouladi, Y Xie, NH Skotte, DE Ehrnhoefer, RK Graham, JE Kim, ...
Human molecular genetics 19 (8), 1528-1538, 2010
|Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes|
A Maillet, K Tan, X Chai, SN Sadananda, A Mehta, J Ooi, MR Hayden, ...
Scientific Reports 6, 25333, 2016
|Mouse models of Huntington disease: variations on a theme|
DE Ehrnhoefer, SL Butland, MA Pouladi, MR Hayden
Disease models & mechanisms 2 (3-4), 123-129, 2009