Mahmoud A. Pouladi
Mahmoud A. Pouladi
Associate Professor, Department of Medical Genetics, University of British Columbia
Verified email at - Homepage
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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
M Bj÷rkqvist, EJ Wild, J Thiele, A Silvestroni, R Andre, N Lahiri, E Raibon, ...
Journal of Experimental Medicine 205 (8), 1869-1877, 2008
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
W Song, J Chen, A Petrilli, G Liot, E Klinglmayr, Y Zhou, P Poquiz, J Tjong, ...
Nature medicine 17 (3), 377-382, 2011
Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice
AJ Milnerwood, CM Gladding, MA Pouladi, AM Kaufman, RM Hines, ...
Neuron 65 (2), 178-190, 2010
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
S Okamoto*, MA Pouladi*, M Talantova*, D Yao*, P Xia, DE Ehrnhoefer, ...
Nature medicine 15 (12), 1407-1413, 2009
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtiná…
A Kuhn, DR Goldstein, A Hodges, AD Strand, T Sengstag, C Kooperberg, ...
Human molecular genetics 16 (15), 1845-1861, 2007
Choosing an animal model for the study of Huntington's disease
MA Pouladi, AJ Morton, MR Hayden
Nature Reviews Neuroscience 14 (10), 708-721, 2013
Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness
CS Robbins, DE Dawe, SI Goncharova, MA Pouladi, AG Drannik, ...
American journal of respiratory cell and molecular biology 30 (2), 202-211, 2004
Impact of Cigarette Smoke on Clearance and Inflammation after Pseudomonas aeruginosa Infection
AG Drannik, MA Pouladi, CS Robbins, SI Goncharova, S Kianpour, ...
American journal of respiratory and critical care medicine 170 (11), 1164-1171, 2004
Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function
K Takata, T Kozaki, CZW Lee, MS Thion, M Otsuka, S Lim, KH Utami, ...
Immunity 47 (1), 183-198. e6, 2017
Inhibition of phosphatidylinositol-4-phosphate 5-kinase Iα impairs localized actin remodeling and suppresses phagocytosis
MG Coppolino, R Dierckman, J Loijens, RF Collins, M Pouladi, ...
Journal of Biological Chemistry 277 (46), 43849-43857, 2002
Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin
MA Pouladi, RK Graham, JM Karasinska, Y Xie, RD Santos, ┼ PetersÚn, ...
Brain 132 (4), 919-932, 2009
Reversal of phenotypic abnormalities by CRISPR/Cas9-mediated gene correction in Huntington disease patient-derived induced pluripotent stem cells
X Xu, Y Tay, B Sim, SI Yoon, Y Huang, J Ooi, KH Utami, A Ziaei, B Ng, ...
Stem cell reports 8 (3), 619-633, 2017
Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice
MA Pouladi, LM Stanek, Y Xie, S Franciosi, AL Southwell, Y Deng, ...
Human molecular genetics 21 (10), 2219-2232, 2012
Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes
M Valenza, V Leoni, JM Karasinska, L Petricca, J Fan, J Carroll, ...
Journal of Neuroscience 30 (32), 10844-10850, 2010
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease
RK Graham, MA Pouladi, P Joshi, G Lu, Y Deng, NP Wu, BE Figueroa, ...
Journal of Neuroscience 29 (7), 2193-2204, 2009
Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo
RK Graham, Y Deng, J Carroll, K Vaid, C Cowan, MA Pouladi, M Metzler, ...
Journal of Neuroscience 30 (45), 15019-15029, 2010
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis
K Becanovic, MA Pouladi, RS Lim, A Kuhn, P Pavlidis, R Luthi-Carter, ...
Human molecular genetics 19 (8), 1438-1452, 2010
Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression
MA Pouladi, Y Xie, NH Skotte, DE Ehrnhoefer, RK Graham, JE Kim, ...
Human molecular genetics 19 (8), 1528-1538, 2010
Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes
A Maillet, K Tan, X Chai, SN Sadananda, A Mehta, J Ooi, MR Hayden, ...
Scientific Reports 6, 25333, 2016
Mouse models of Huntington disease: variations on a theme
DE Ehrnhoefer, SL Butland, MA Pouladi, MR Hayden
Disease models & mechanisms 2 (3-4), 123-129, 2009
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