Shannon K Hughes
Shannon K Hughes
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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function
IK Zervantonakis, SK Hughes-Alford, JL Charest, JS Condeelis, FB Gertler, ...
Proceedings of the National Academy of Sciences 109 (34), 13515-13520, 2012
The human tumor atlas network: charting tumor transitions across space and time at single-cell resolution
O Rozenblatt-Rosen, A Regev, P Oberdoerffer, T Nawy, A Hupalowska, ...
Cell 181 (2), 236-249, 2020
Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer
ET Roussos, M Balsamo, SK Alford, JB Wyckoff, B Gligorijevic, Y Wang, ...
Journal of cell science 124 (13), 2120-2131, 2011
2D protrusion but not motility predicts growth factor–induced cancer cell migration in 3D collagen
AS Meyer, SK Hughes-Alford, JE Kay, A Castillo, A Wells, FB Gertler, ...
Journal of Cell Biology 197 (6), 721-729, 2012
Mena binds α5 integrin directly and modulates α5β1 function
SL Gupton, D Riquelme, SK Hughes-Alford, J Tadros, SS Rudina, ...
Journal of Cell Biology 198 (4), 657-676, 2012
Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate
BK Wacker, SK Alford, EA Scott, MD Thakur, GD Longmore, DL Elbert
Biophysical journal 94 (1), 273-285, 2008
Delivery of sphingosine 1-phosphate from poly (ethylene glycol) hydrogels
BK Wacker, EA Scott, MM Kaneda, SK Alford, DL Elbert
Biomacromolecules 7 (4), 1335-1343, 2006
RAS mutations affect tumor necrosis factor–induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects
PK Kreeger, R Mandhana, SK Alford, KM Haigis, DA Lauffenburger
Cancer research 69 (20), 8191-8199, 2009
The making of a PreCancer Atlas: promises, challenges, and opportunities
S Srivastava, S Ghosh, J Kagan, R Mazurchuk, E Boja, R Chuaqui, ...
Trends in Cancer 4 (8), 523-536, 2018
PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena
SK Hughes, MJ Oudin, J Tadros, J Neil, A Del Rosario, BA Joughin, ...
Molecular biology of the cell 26 (21), 3867-3878, 2015
CD46-induced immunomodulatory CD4+ T cells express the adhesion molecule and chemokine receptor pattern of intestinal T cells
SK Alford, GD Longmore, WF Stenson, C Kemper
The Journal of Immunology 181 (4), 2544-2555, 2008
α-Actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation
Y Feng, H Ngu, SK Alford, M Ward, F Yin, GD Longmore
Experimental cell research 319 (8), 1124-1135, 2013
Characterization of the expression of the pro-metastatic MenaINV isoform during breast tumor progression
MJ Oudin, SK Hughes, N Rohani, MN Moufarrej, JG Jones, JS Condeelis, ...
Clinical & experimental metastasis 33, 249-261, 2016
Quantitative analysis of gradient sensing: towards building predictive models of chemotaxis in cancer
SK Hughes-Alford, DA Lauffenburger
Current opinion in cell biology 24 (2), 284-291, 2012
Fluid shear stress modulates cell migration induced by sphingosine 1-phosphate and vascular endothelial growth factor
SK Hughes, BK Wacker, MM Kaneda, DL Elbert
Annals of biomedical engineering 33, 1003-1014, 2005
Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts
HD Kim, AS Meyer, JP Wagner, SK Alford, A Wells, FB Gertler, ...
Molecular & Cellular Proteomics 10 (11), 2011
Systems approaches to cancer biology
TC Archer, EJ Fertig, SJC Gosline, M Hafner, SK Hughes, BA Joughin, ...
Cancer research 76 (23), 6774-6777, 2016
MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis
MJ Oudin, MA Miller, JAZ Klazen, T Kosciuk, A Lussiez, SK Hughes, ...
Molecular Biology of the Cell 27 (20), 3085-3094, 2016
Endothelial cell migration in human plasma is enhanced by a narrow range of added sphingosine 1‐phosphate: Implications for biomaterials design
SK Alford, MM Kaneda, BK Wacker, DL Elbert
Journal of Biomedical Materials Research Part A: An Official Journal of The …, 2009
Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements
SK Alford, Y Wang, Y Feng, GD Longmore, DL Elbert
Annals of biomedical engineering 38, 2775-2790, 2010
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