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TJ Cradick
TJ Cradick
Other namesThomas Cradick, Thomas J Cradick
#CRISPR Consulting https://geneeditingfrontiers.com
Verified email at alum.mit.edu - Homepage
Title
Cited by
Cited by
Year
DNA targeting specificity of RNA-guided Cas9 nucleases
PD Hsu, DA Scott, JA Weinstein, FA Ran, S Konermann, V Agarwala, Y Li, ...
Nature biotechnology 31 (9), 827-832, 2013
53342013
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity
TJ Cradick, EJ Fine, CJ Antico, G Bao
Nucleic acids research 41 (20), 9584-9592, 2013
7782013
CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
Y Lin, TJ Cradick, MT Brown, H Deshmukh, P Ranjan, N Sarode, BM Wile, ...
Nucleic acids research 42 (11), 7473-7485, 2014
7262014
Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
L Ye, J Wang, AI Beyer, F Teque, TJ Cradick, Z Qi, JC Chang, G Bao, ...
Proceedings of the National Academy of Sciences 111 (26), 9591-9596, 2014
4102014
COSMID: a web-based tool for identifying and validating CRISPR/Cas off-target sites
TJ Cradick, P Qiu, CM Lee, EJ Fine, G Bao
Molecular Therapy-Nucleic Acids 3, 2014
3802014
Streptococcus thermophilus CRISPR-Cas9 systems enable specific editing of the human genome
M Müller, CM Lee, G Gasiunas, TH Davis, TJ Cradick, V Siksnys, G Bao, ...
Molecular Therapy 24 (3), 636-644, 2016
2922016
The Neisseria meningitidis CRISPR-Cas9 system enables specific genome editing in mammalian cells
CM Lee, TJ Cradick, G Bao
Molecular Therapy 24 (3), 645-654, 2016
2562016
TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity
C Mussolino, J Alzubi, EJ Fine, R Morbitzer, TJ Cradick, T Lahaye, G Bao, ...
Nucleic acids research 42 (10), 6762-6773, 2014
2302014
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects
CL Ramirez, MT Certo, C Mussolino, MJ Goodwin, TJ Cradick, ...
Nucleic Acids Research, 2012
2302012
Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis b virus DNAs
TJ Cradick, K Keck, S Bradshaw, AC Jamieson, AP McCaffrey
Molecular Therapy 18 (5), 947-954, 2010
2182010
Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus
C Antoniani, V Meneghini, A Lattanzi, T Felix, O Romano, E Magrin, ...
Blood, The Journal of the American Society of Hematology 131 (17), 1960-1973, 2018
2032018
An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage
EJ Fine, TJ Cradick, CL Zhao, Y Lin, G Bao
Nucleic acids research 42 (6), e42-e42, 2014
1542014
Nuclease target site selection for maximizing on-target activity and minimizing off-target effects in genome editing
CM Lee, TJ Cradick, EJ Fine, G Bao
Molecular Therapy 24 (3), 475-487, 2016
1412016
A burden of rare variants associated with extremes of gene expression in human peripheral blood
J Zhao, I Akinsanmi, D Arafat, TJ Cradick, CM Lee, S Banskota, ...
The American Journal of Human Genetics 98 (2), 299-309, 2016
1042016
Defining critical residues in the epitope for a hiv-neutralizing monoclonal antibody using phage display and peptide array technologies
CL Jellis, TJ Cradick, P Rennert, P Salinas, J Boyd, T Amirault, GS Gray
Gene 137 (1), 63-68, 1993
771993
SAPTA: a new design tool for improving TALE nuclease activity
Y Lin, EJ Fine, Z Zheng, CJ Antico, RA Voit, MH Porteus, TJ Cradick, ...
Nucleic acids research 42 (6), e47-e47, 2014
692014
Efficient fdCas9 synthetic endonuclease with improved specificity for precise genome engineering
M Aouida, A Eid, Z Ali, T Cradick, C Lee, H Deshmukh, A Atef, ...
PloS one 10 (7), e0133373, 2015
662015
ZFN-Site searches genomes for zinc finger nuclease target sites and off-target sites
TJ Cradick, G Ambrosini, C Iseli, P Bucher, AP McCaffrey
BMC bioinformatics 12 (1), 152, 2011
612011
TALENs facilitate single-step seamless SDF correction of F508del CFTR in airway epithelial submucosal gland cell-derived CF-iPSCs
S Suzuki, RG Sargent, B Illek, H Fischer, A Esmaeili-Shandiz, MJ Yezzi, ...
Molecular Therapy-Nucleic Acids 5, 2016
462016
Evaluation of homology-independent CRISPR-Cas9 off-target assessment methods
HG Chaudhari, J Penterman, HJ Whitton, SJ Spencer, N Flanagan, ...
The CRISPR Journal 3 (6), 440-453, 2020
432020
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