| Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo S Hoffmeyer, O Burk, O Von Richter, HP Arnold, J Brockmöller, A Johne, ... Proceedings of the National Academy of Sciences 97 (7), 3473-3478, 2000 | 3348 | 2000 |
| Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects* I Cascorbi, T Gerloff, A Johne, C Meisel, S Hoffmeyer, M Schwab, ... Clinical Pharmacology & Therapeutics 69 (3), 169-174, 2001 | 922 | 2001 |
| Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1 A Siddiqui, R Kerb, ME Weale, U Brinkmann, A Smith, DB Goldstein, ... New England Journal of Medicine 348 (15), 1442-1448, 2003 | 853 | 2003 |
| The making of bispecific antibodies U Brinkmann, RE Kontermann MAbs 9 (2), 182-212, 2017 | 811 | 2017 |
| Bispecific antibodies RE Kontermann, U Brinkmann Drug discovery today 20 (7), 838-847, 2015 | 646 | 2015 |
| A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies J Buchner, I Pastan, U Brinkmann Analytical biochemistry 205 (2), 263-270, 1992 | 594 | 1992 |
| High-level expression of recombinant genes in Escherichia coli is dependent on the availability of the dnaY gene product U Brinkmann, RE Mattes, P Buckel Gene 85 (1), 109-114, 1989 | 568 | 1989 |
| Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis M Schwab, E Schaeffeler, C Marx, MF Fromm, B Kaskas, J Metzler, ... Gastroenterology 124 (1), 26-33, 2003 | 435 | 2003 |
| Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene* A Johne, K Köpke, T Gerloff, I Mai, S Rietbrock, C Meisel, S Hoffmeyer, ... Clinical Pharmacology & Therapeutics 72 (5), 584-594, 2002 | 417 | 2002 |
| Frequency of C3435T polymorphism of MDR1 gene in African people E Schaeffeler, M Eichelbaum, U Brinkmann, A Penger, S Asante-Poku, ... The Lancet 358 (9279), 383-384, 2001 | 367 | 2001 |
| Association of the P-glycoprotein transporter MDR1C3435T polymorphism with the susceptibility to renal epithelial tumors M Siegsmund, U Brinkmann, E Scháffeler, G Weirich, M Schwab, ... Journal of the American Society of Nephrology 13 (7), 1847-1854, 2002 | 346 | 2002 |
| MDR1 gene polymorphisms and disposition of the P‐glycoprotein substrate fexofenadine S Drescher, E Schaeffeler, M Hitzl, U Hofmann, M Schwab, U Brinkmann, ... British journal of clinical pharmacology 53 (5), 526-534, 2002 | 342 | 2002 |
| A recombinant immunotoxin containing a disulfide-stabilized Fv fragment U Brinkmann, Y Reiter, SH Jung, B Lee, I Pastan Proceedings of the National Academy of Sciences 90 (16), 7538-7542, 1993 | 336 | 1993 |
| Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene K Gellner, R Eiselt, E Hustert, H Arnold, I Koch, M Haberl, CJ Deglmann, ... Pharmacogenetics and Genomics 11 (2), 111-121, 2001 | 333 | 2001 |
| Engineering antibody Fv fragments for cancer detection and therapy: bisulfide-stabilized Fv fragments Y Reiter, U Brinkmann, B Lee, I Pastan Nature biotechnology 14 (10), 1239-1245, 1996 | 326 | 1996 |
| B3 (Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice U Brinkmann, LEEH PAi, DJ FitzGerald, M Willingham, I Pastan Proceedings of the National Academy of Sciences 88 (19), 8616-8620, 1991 | 313 | 1991 |
| Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4 E Hustert, A Zibat, E Presecan-Siedel, R Eiselt, R Mueller, C Fuß, I Brehm, ... Drug metabolism and disposition 29 (11), 1454-1459, 2001 | 296 | 2001 |
| ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2 R Kerb, S Hoffmeyer, U Brinkmann Pharmacogenomics 2 (1), 51-64, 2001 | 275 | 2001 |
| Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies C Klein, C Sustmann, M Thomas, K Stubenrauch, R Croasdale, ... MAbs 4 (6), 653-663, 2012 | 263 | 2012 |
| Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences R Kerb, U Brinkmann, N Chatskaia, D Gorbunov, V Gorboulev, ... Pharmacogenetics and Genomics 12 (8), 591-595, 2002 | 261 | 2002 |
Christian KleinRoche Pharma Research and Early Development, Roche Innovation Center ZurichVerified email at roche.com
