| WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification GS Coombs, J Yu, CA Canning, CA Veltri, TM Covey, JK Cheong, ... Journal of cell science 123 (19), 3357-3367, 2010 | 209 | 2010 |
| Protein phosphatase 1 regulates assembly and function of the β‐catenin degradation complex W Luo, A Peterson, BA Garcia, G Coombs, B Kofahl, R Heinrich, ... The EMBO journal 26 (6), 1511-1521, 2007 | 168 | 2007 |
| Substrate specificity of prostate-specific antigen (PSA) GS Coombs, RC Bergstrom, JL Pellequer, SI Baker, M Navre, MM Smith, ... Chemistry & biology 5 (9), 475-488, 1998 | 153 | 1998 |
| Optimal subsite occupancy and design of a selective inhibitor of urokinase SH Ke, GS Coombs, K Tachias, DR Corey, EL Madison Journal of Biological Chemistry 272 (33), 20456-20462, 1997 | 151 | 1997 |
| Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase R Friedrich, P Fuentes-Prior, E Ong, G Coombs, M Hunter, R Oehler, ... Journal of Biological Chemistry 277 (3), 2160-2168, 2002 | 146 | 2002 |
| Origins of the specificity of tissue-type plasminogen activator. L Ding, GS Coombs, L Strandberg, M Navre, DR Corey, EL Madison Proceedings of the National Academy of Sciences 92 (17), 7627-7631, 1995 | 104 | 1995 |
| Substrate Specificity of Tissue Type Plasminogen Activator: CHARACTERIZATION OF THE FIBRIN INDEPENDENT SPECIFICITY OF t-PA FOR PLASMINOGEN (∗) EL Madison, GS Coombs, DR Corey Journal of Biological Chemistry 270 (13), 7558-7562, 1995 | 100 | 1995 |
| Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer TM Covey, K Edes, GS Coombs, DM Virshup, FA Fitzpatrick PLoS One 5 (10), e13545, 2010 | 90 | 2010 |
| Negative selectivity and the evolution of protease cascades: the specificity of plasmin for peptide and protein substrates LS Hervio, GS Coombs, RC Bergstrom, K Trivedi, DR Corey, EL Madison Chemistry & biology 7 (6), 443-452, 2000 | 88 | 2000 |
| Distinguishing the specificities of closely related proteases: role of P3 in substrate and inhibitor discrimination between tissue-type plasminogen activator and urokinase SH Ke, GS Coombs, K Tachias, M Navre, DR Corey, EL Madison Journal of Biological Chemistry 272 (26), 16603-16609, 1997 | 84 | 1997 |
| Wnt signaling in development, disease and translational medicine GS Coombs, TM Covey, DM Virshup Current drug targets 9 (7), 513-531, 2008 | 83 | 2008 |
| Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer GS Coombs, AA Schmitt, CA Canning, A Alok, ICC Low, N Banerjee, ... Oncogene 31 (2), 213-225, 2012 | 77 | 2012 |
| Negative Regulation of LRP6 Function by Casein Kinase I ϵ Phosphorylation W Swiatek, H Kang, BA Garcia, J Shabanowitz, GS Coombs, DF Hunt, ... Journal of biological chemistry 281 (18), 12233-12241, 2006 | 68 | 2006 |
| ToIC and DsbA are needed for the secretion of STB, a heat‐stable enterotoxin of Escherichia coli DT Foreman, Y Martinez, G Coombs, A Torres, YM Kupersztoch Molecular microbiology 18 (2), 237-245, 1995 | 66 | 1995 |
| Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains GS Coombs, MS Rao, AJ Olson, PE Dawson, EL Madison Journal of biological chemistry 274 (34), 24074-24079, 1999 | 56 | 1999 |
| Distinct Mechanisms Contribute to Stringent Substrate Specificity of Tissue-type Plasminogen Activator (∗) GS Coombs, AT Dang, EL Madison, DR Corey Journal of Biological Chemistry 271 (8), 4461-4467, 1996 | 51 | 1996 |
| Trypsin specificity increased through substrate-assisted catalysis DR Corey, WS Willett, GS Coombs, CS Craik Biochemistry 34 (36), 11521-11527, 1995 | 49 | 1995 |
| Crystals of urokinase type plasminogen activator complexes reveal the binding mode of peptidomimetic inhibitors E Zeslawska, U Jacob, A Schweinitz, G Coombs, W Bode, E Madison Journal of molecular biology 328 (1), 109-118, 2003 | 48 | 2003 |
| Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives MWB McCulloch, GS Coombs, N Banerjee, TS Bugni, KM Cannon, ... Bioorganic & medicinal chemistry 17 (6), 2189-2198, 2009 | 47 | 2009 |
| Directing sequence-specific proteolysis to new targets: the influence of loop size and target sequence on selective proteolysis by tissue-type plasminogen activator and … GS Coombs, RC Bergstrom, EL Madison, DR Corey Journal of Biological Chemistry 273 (8), 4323-4328, 1998 | 41 | 1998 |
Tracy M. CoveyProfessor of Chemistry, Weber State UniversityVerified email at weber.edu
