A Src-like inactive conformation in the abl tyrosine kinase domain NM Levinson, O Kuchment, K Shen, MA Young, M Koldobskiy, M Karplus, ... PLoS biology 4 (5), e144, 2006 | 354 | 2006 |
A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity NM Levinson, SG Boxer Nature chemical biology 10 (2), 127-132, 2014 | 161 | 2014 |
Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain NM Levinson, SG Boxer PloS one 7 (4), e29828, 2012 | 146 | 2012 |
Structural basis for the recognition of c-Src by its inactivator Csk NM Levinson, MA Seeliger, PA Cole, J Kuriyan Cell 134 (1), 124-134, 2008 | 145 | 2008 |
Experimental quantification of electrostatics in X–H··· π hydrogen bonds M Saggu, NM Levinson, SG Boxer Journal of the American Chemical Society 134 (46), 18986-18997, 2012 | 130 | 2012 |
Solvent-induced infrared frequency shifts in aromatic nitriles are quantitatively described by the vibrational Stark effect NM Levinson, SD Fried, SG Boxer The journal of physical chemistry B 116 (35), 10470-10476, 2012 | 120 | 2012 |
Direct measurements of electric fields in weak OH··· π hydrogen bonds M Saggu, NM Levinson, SG Boxer Journal of the American Chemical Society 133 (43), 17414-17419, 2011 | 120 | 2011 |
A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation EF Ruff, JM Muretta, AR Thompson, EW Lake, S Cyphers, SK Albanese, ... Elife 7, e32766, 2018 | 62 | 2018 |
A water-mediated allosteric network governs activation of Aurora kinase A S Cyphers, EF Ruff, JM Behr, JD Chodera, NM Levinson Nature chemical biology 13 (4), 402-408, 2017 | 61 | 2017 |
The multifaceted allosteric regulation of Aurora kinase A NM Levinson Biochemical Journal 475 (12), 2025-2042, 2018 | 57 | 2018 |
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states EW Lake, JM Muretta, AR Thompson, DM Rasmussen, A Majumdar, ... Proceedings of the National Academy of Sciences 115 (51), E11894-E11903, 2018 | 55 | 2018 |
Phosphate vibrations probe local electric fields and hydration in biomolecules NM Levinson, EE Bolte, CS Miller, SA Corcelli, SG Boxer Journal of the American Chemical Society 133 (34), 13236-13239, 2011 | 50 | 2011 |
An open library of human kinase domain constructs for automated bacterial expression SK Albanese, DL Parton, M Işık, L Rodríguez-Laureano, SM Hanson, ... Biochemistry 57 (31), 4675-4689, 2018 | 44 | 2018 |
The tyrosine kinase Csk dimerizes through Its SH3 domain NM Levinson, PR Visperas, J Kuriyan PloS one 4 (11), e7683, 2009 | 32 | 2009 |
Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry N Tavernier, Y Thomas, S Vigneron, P Maisonneuve, S Orlicky, P Mader, ... Nature communications 12 (1), 1899, 2021 | 23 | 2021 |
Allostery governs Cdk2 activation and differential recognition of CDK inhibitors A Majumdar, DJ Burban, JM Muretta, AR Thompson, TA Engel, ... Nature chemical biology 17 (4), 456-464, 2021 | 19 | 2021 |
The pseudokinase domains of guanylyl cyclase–A and–B allosterically increase the affinity of their catalytic domains for substrate AB Edmund, TF Walseth, NM Levinson, LR Potter Science signaling 12 (566), eaau5378, 2019 | 14 | 2019 |
Cooperativity between orthosteric inhibitors and allosteric inhibitor 8-anilino-1-naphthalene sulfonic acid (ANS) in cyclin-dependent kinase 2 EB Faber, D Tian, D Burban, NM Levinson, JE Hawkinson, GI Georg ACS chemical biology 15 (7), 1759-1764, 2020 | 12 | 2020 |
Screening through lead optimization of high affinity, allosteric cyclin-dependent kinase 2 (CDK2) inhibitors as male contraceptives that reduce sperm counts in mice EB Faber, N Wang, K John, L Sun, HL Wong, D Burban, R Francis, D Tian, ... Journal of medicinal chemistry 66 (3), 1928-1940, 2023 | 8 | 2023 |
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding EB Faber, L Sun, J Tang, E Roberts, S Ganeshkumar, N Wang, ... Nature communications 14 (1), 3213, 2023 | 5 | 2023 |