|The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis|
SPS Rao, S Alonso, L Rand, T Dick, K Pethe
Proceedings of the National Academy of Sciences 105 (33), 11945-11950, 2008
|Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis|
K Pethe, P Bifani, J Jang, S Kang, S Park, S Ahn, J Jiricek, J Jung, ...
Nature medicine 19 (9), 1157-1160, 2013
|Use of proteomics to identify novel virulence determinants that are required for Edwardsiella tarda pathogenesis|
PS Srinivasa Rao, Y Yamada, YP Tan, KY Leung
Molecular microbiology 53 (2), 573-586, 2004
|A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy|
K Pethe, PC Sequeira, S Agarwalla, K Rhee, K Kuhen, WY Phong, V Patel, ...
Nature communications 1, 57, 2010
|Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability|
M Gengenbacher, SPS Rao, K Pethe, T Dick
Microbiology 156 (1), 81-87, 2010
|Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness|
S Khare, AS Nagle, A Biggart, YH Lai, F Liang, LC Davis, SW Barnes, ...
Nature 537 (7619), 229-233, 2016
|Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis|
S Hasan, S Daugelat, PSS Rao, M Schreiber
PLoS computational biology 2 (6), 2006
|Opsonized virulent Edwardsiella tarda strains are able to adhere to and survive and replicate within fish phagocytes but fail to stimulate reactive oxygen intermediates|
PSS Rao, TM Lim, KY Leung
Infection and immunity 69 (9), 5689-5697, 2001
|A type III secretion system is required for Aeromonas hydrophila AH-1 pathogenesis|
HB Yu, PSS Rao, HC Lee, S Vilches, S Merino, JM Tomas, KY Leung
Infection and immunity 72 (3), 1248-1256, 2004
|Functional genomics approach to the identification of virulence genes involved in Edwardsiella tarda pathogenesis|
PSS Rao, TM Lim, KY Leung
Infection and immunity 71 (3), 1343-1351, 2003
|The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease|
EK Schmitt, M Riwanto, V Sambandamurthy, S Roggo, C Miault, ...
Angewandte Chemie International Edition 50 (26), 5889-5891, 2011
|Triacylglycerol utilization is required for regrowth of in vitro hypoxic nonreplicating Mycobacterium bovis bacillus Calmette-Guerin|
KL Low, PSS Rao, G Shui, AK Bendt, K Pethe, T Dick, MR Wenk
Journal of bacteriology 191 (16), 5037-5043, 2009
|The effectiveness of a commercial microbial product in poorly prepared tiger shrimp, Penaeus monodon (Fabricius), ponds|
M Shariff, FM Yusoff, TN Devaraja, PS Rao
Aquaculture Research 32 (3), 181-187, 2001
|A major catalase (KatB) that is required for resistance to H2O2 and phagocyte-mediated killing in Edwardsiella tarda|
PSS Rao, Y Yamada, KY Leung
Microbiology 149 (9), 2635-2644, 2003
|A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis|
PA Mak, SPS Rao, M Ping Tan, X Lin, J Chyba, J Tay, SH Ng, BH Tan, ...
ACS chemical biology 7 (7), 1190-1197, 2012
|Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis|
SPS Rao, SB Lakshminarayana, RR Kondreddi, M Herve, LR Camacho, ...
Science translational medicine 5 (214), 214ra168-214ra168, 2013
|Edwardsiella tarda mutants defective in siderophore production, motility, serum resistance and catalase activity|
JA Mathew, YP Tan, PSS Rao, TM Lim, KY Leung
Microbiology 147 (2), 449-457, 2001
|Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents|
SB Lakshminarayana, TB Huat, PC Ho, UH Manjunatha, V Dartois, T Dick, ...
Journal of Antimicrobial Chemotherapy 70 (3), 857-867, 2015
|Direct inhibitors of InhA are active against Mycobacterium tuberculosis|
UH Manjunatha, SPS Rao, RR Kondreddi, CG Noble, LR Camacho, ...
Science translational medicine 7 (269), 269ra3-269ra3, 2015
|Design, synthesis and biological evaluation of indole-2-carboxamides, a promising class of anti-tuberculosis agents|
PWS Ravinder Reddy Kondreddi, Jan Jiricek, Srinivasa P
Journal of Medicinal Chemistry, 2013