Tadashi Honda
Tadashi Honda
Research Professor of Chemistry, Stony Brook University
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Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress
AT Dinkova-Kostova, KT Liby, KK Stephenson, WD Holtzclaw, X Gao, ...
Proceedings of the National Academy of Sciences 102 (12), 4584-4589, 2005
Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages
N Suh, T Honda, HJ Finlay, A Barchowsky, C Williams, NE Benoit, Q Xie, ...
Cancer research 58 (4), 717-723, 1998
A novel synthetic oleanane triterpenoid, 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity
N Suh, Y Wang, T Honda, GW Gribble, E Dmitrovsky, WF Hickey, ...
Cancer research 59 (2), 336-341, 1999
Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages
T Honda, BAV Rounds, L Bore, HJ Finlay, FG Favaloro, N Suh, Y Wang, ...
Journal of medicinal chemistry 43 (22), 4233-4246, 2000
The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling
K Liby, T Hock, MM Yore, N Suh, AE Place, R Risingsong, CR Williams, ...
Cancer research 65 (11), 4789-4798, 2005
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes
MS Yates, M Tauchi, F Katsuoka, KC Flanders, KT Liby, T Honda, ...
Molecular cancer therapeutics 6 (1), 154-162, 2007
Design and synthesis of 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages
T Honda, BAV Rounds, GW Gribble, N Suh, Y Wang, MB Sporn
Bioorganic & medicinal chemistry letters 8 (19), 2711-2714, 1998
Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-, 12-dioxooleana-1, 9 (11)-dien-28-oyl …
MS Yates, MK Kwak, PA Egner, JD Groopman, S Bodreddigari, TR Sutter, ...
Cancer research 66 (4), 2488-2494, 2006
A synthetic triterpenoid, 2-cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor γ
Y Wang, WW Porter, N Suh, T Honda, GW Gribble, LM Leesnitzer, ...
Molecular endocrinology 14 (10), 1550-1556, 2000
Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia
M Konopleva, T Tsao, P Ruvolo, I Stiouf, Z Estrov, CE Leysath, S Zhao, ...
Blood, The Journal of the American Society of Hematology 99 (1), 326-335, 2002
The Novel Synthetic Triterpenoid, CDDO-Imidazolide, Inhibits Inflammatory Response and Tumor Growth in Vivo
AE Place, N Suh, CR Williams, R Risingsong, T Honda, Y Honda, ...
Clinical Cancer Research 9 (7), 2798-2806, 2003
A novel dicyanotriterpenoid, 2-cyano-3, 12-dioxooleana-1, 9 (11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production
T Honda, Y Honda, FG Favaloro Jr, GW Gribble, N Suh, AE Place, ...
Bioorganic & medicinal chemistry letters 12 (7), 1027-1030, 2002
Experimental nonalcoholic steatohepatitis and liver fibrosis are ameliorated by pharmacologic activation of Nrf2 (NF-E2 p45-related factor 2)
RS Sharma, DJ Harrison, D Kisielewski, DM Cassidy, AD McNeilly, ...
Cellular and molecular gastroenterology and hepatology 5 (3), 367-398, 2018
Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages
T Honda, GW Gribble, N Suh, HJ Finlay, BAV Rounds, L Bore, ...
Journal of medicinal chemistry 43 (9), 1866-1877, 2000
The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice
K Liby, DB Royce, CR Williams, R Risingsong, MM Yore, T Honda, ...
Cancer research 67 (6), 2414-2419, 2007
The novel triterpenoid 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism
Y Ito, P Pandey, A Place, MB Sporn, GW Gribble, T Honda, S Kharbanda, ...
New enone derivatives of oleanolic acid and ursolic acid as inhibitors of nitric oxide production in mouse macrophages
T Honda, HJ Finlay, GW Gribble, N Suh, MB Sporn
Bioorganic & Medicinal Chemistry Letters 7 (13), 1623-1628, 1997
The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti–multiple myeloma (MM) activity and overcome bortezomib resistance
D Chauhan, G Li, K Podar, T Hideshima, R Shringarpure, L Catley, ...
Blood 103 (8), 3158-3166, 2004
The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells
K Liby, N Voong, CR Williams, R Risingsong, DB Royce, T Honda, ...
Clinical Cancer Research 12 (14), 4288-4293, 2006
An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1
AT Dinkova-Kostova, P Talalay, J Sharkey, Y Zhang, WD Holtzclaw, ...
Journal of Biological Chemistry 285 (44), 33747-33755, 2010
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