Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide MJ Macias, M Hyvönen, E Baraldi, J Schultz, M Sudol, M Saraste, ... Nature 382 (6592), 646-649, 1996 | 562 | 1996 |
PH domain: the first anniversary TJ Gibson, M Hyvönen, A Musacchio, M Saraste, E Birney Trends in biochemical sciences 19 (9), 349-353, 1994 | 437 | 1994 |
Structure of the binding site for inositol phosphates in a PH domain. M Hyvönen, MJ Macias, M Nilges, H Oschkinat, M Saraste, M Wilmanns The EMBO journal 14 (19), 4676-4685, 1995 | 411 | 1995 |
Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics PY Colin, B Kintses, F Gielen, CM Miton, G Fischer, MF Mohamed, ... Nature communications 6 (1), 10008, 2015 | 398 | 2015 |
T7 Vectors with a Modified T7lacPromoter for Expression of Proteins inEscherichia coli J Peränen, M Rikkonen, M Hyvönen, L Kääriäinen Analytical biochemistry 236 (2), 371-373, 1996 | 338 | 1996 |
Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia M Hyvönen, M Saraste The EMBO journal 16 (12), 3396-3404, 1997 | 288 | 1997 |
Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1, 3, 4, 5-tetrakisphosphate E Baraldi, KD Carugo, M Hyvönen, PL Surdo, AM Riley, BVL Potter, ... Structure 7 (4), 449-460, 1999 | 243 | 1999 |
Functionalised staple linkages for modulating the cellular activity of stapled peptides YH Lau, P De Andrade, ST Quah, M Rossmann, L Laraia, N Sköld, ... Chemical Science 5 (5), 1804-1809, 2014 | 209 | 2014 |
Structural basis for the inhibition of activin signalling by follistatin AE Harrington, SA MorrisTriggs, BT Ruotolo, CV Robinson, S Ohnuma, ... The EMBO journal 25 (5), 1035-1045, 2006 | 206 | 2006 |
Using a fragmentbased approach to target protein–protein interactions DE Scott, MT Ehebauer, T Pukala, M Marsh, TL Blundell, ... ChemBioChem 14 (3), 332-342, 2013 | 142 | 2013 |
Pleckstrin homology domains: a fact file M Saraste, M Hyvönen Current opinion in structural biology 5 (3), 403-408, 1995 | 136 | 1995 |
The alphavirus replicase protein nsP1 is membrane-associated and has affinity to endocytic organelles J Peränen, P Laakkonen, M Hyvönen, L Kääriäinen Virology 208 (2), 610-620, 1995 | 136 | 1995 |
Expression of Semliki Forest virus nsP1-specific methyltransferase in insect cells and in Escherichia coli P Laakkonen, M Hyvönen, J Peränen, L Kääriäinen Journal of virology 68 (11), 7418-7425, 1994 | 135 | 1994 |
A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates SJ Walsh, S Omarjee, WRJD Galloway, TTL Kwan, HF Sore, JS Parker, ... Chemical Science 10 (3), 694-700, 2019 | 127 | 2019 |
Targeting protein–protein interactions and fragment-based drug discovery E Valkov, T Sharpe, M Marsh, S Greive, M Hyvönen Fragment-Based Drug Discovery and X-Ray Crystallography, 145-179, 2012 | 123 | 2012 |
Double strainpromoted macrocyclization for the rapid selection of cellactive stapled peptides YH Lau, Y Wu, M Rossmann, BX Tan, P de Andrade, YS Tan, C Verma, ... Angewandte Chemie International Edition 54 (51), 15410-15413, 2015 | 119 | 2015 |
An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily B van Loo, S Jonas, AC Babtie, A Benjdia, O Berteau, M Hyvönen, ... Proceedings of the National Academy of Sciences 107 (7), 2740-2745, 2010 | 118 | 2010 |
Alternative modulation of protein–protein interactions by small molecules G Fischer, M Rossmann, M Hyvönen Current opinion in biotechnology 35, 78-85, 2015 | 98 | 2015 |
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2 M Janeček, M Rossmann, P Sharma, A Emery, DJ Huggins, SR Stockwell, ... Scientific Reports 6 (1), 28528, 2016 | 95 | 2016 |
Development of a new antibody to the human inhibin/activin βB subunit and its application to improved inhibin B ELISAs H Ludlow, S Muttukrishna, M Hyvönen, NP Groome Journal of immunological methods 329 (1-2), 102-111, 2008 | 87 | 2008 |