Thomas Kensler
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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
TW Kensler, N Wakabayashi, S Biswal
Annu. Rev. Pharmacol. Toxicol. 47, 89-116, 2007
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
RK Thimmulappa, KH Mai, S Srisuma, TW Kensler, M Yamamoto, ...
Cancer research 62 (18), 5196-5203, 2002
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
M Ramos-Gomez, MK Kwak, PM Dolan, K Itoh, M Yamamoto, P Talalay, ...
Proceedings of the National Academy of Sciences 98 (6), 3410-3415, 2001
The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis
M Yamamoto, TW Kensler, H Motohashi
Physiological reviews 98 (3), 1169-1203, 2018
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice
T Rangasamy, CY Cho, RK Thimmulappa, L Zhen, SS Srisuma, ...
The Journal of clinical investigation 114 (9), 1248-1259, 2004
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers
N Wakabayashi, AT Dinkova-Kostova, WD Holtzclaw, MI Kang, ...
Proceedings of the National Academy of Sciences 101 (7), 2040-2045, 2004
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
RK Thimmulappa, H Lee, T Rangasamy, SP Reddy, M Yamamoto, ...
The Journal of clinical investigation 116 (4), 984-995, 2016
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
JW Fahey, X Haristoy, PM Dolan, TW Kensler, I Scholtus, KK Stephenson, ...
Proceedings of the National Academy of Sciences 99 (11), 7610-7615, 2002
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.
Y Zhang, TW Kensler, CG Cho, GH Posner, P Talalay
Proceedings of the National Academy of Sciences 91 (8), 3147-3150, 1994
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
A Cuadrado, AI Rojo, G Wells, JD Hayes, SP Cousin, WL Rumsey, ...
Nature reviews Drug discovery 18 (4), 295-317, 2019
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele …
RH Hruban, AD Van Mansfeld, GJ Offerhaus, DH Van Weering, ...
The American journal of pathology 143 (2), 545, 1993
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
D Malhotra, E Portales-Casamar, A Singh, S Srivastava, D Arenillas, ...
Nucleic acids research 38 (17), 5718-5734, 2010
Role of NRF2 in protection against hyperoxic lung injury in mice
HY Cho, AE Jedlicka, SPM Reddy, TW Kensler, M Yamamoto, LY Zhang, ...
American journal of respiratory cell and molecular biology 26 (2), 175-182, 2002
Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway: identification of novel gene clusters for cell survival
MK Kwak, N Wakabayashi, K Itoh, H Motohashi, M Yamamoto, ...
Journal of Biological Chemistry 278 (10), 8135-8145, 2003
Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology
TW Kensler, BD Roebuck, GN Wogan, JD Groopman
Toxicological sciences 120 (suppl_1), S28-S48, 2011
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter
MK Kwak, K Itoh, M Yamamoto, TW Kensler
Molecular and cellular biology 22 (9), 2883-2892, 2002
Oxidative mechanisms in carcinogenesis
KZ Guyton, TW Kensler
British medical bulletin 49 (3), 523-544, 1993
The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
J Wakabayashi, Z Zhang, N Wakabayashi, Y Tamura, M Fukaya, ...
Journal of Cell Biology 186 (6), 805-816, 2009
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
T Rangasamy, J Guo, WA Mitzner, J Roman, A Singh, AD Fryer, ...
The Journal of experimental medicine 202 (1), 47-59, 2005
When NRF2 talks, who's listening?
N Wakabayashi, SL Slocum, JJ Skoko, S Shin, TW Kensler
Antioxidants & redox signaling 13 (11), 1649-1663, 2010
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