Peng Lei
Peng Lei
West China Hospital, Sichuan University
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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
P Lei, S Ayton, DI Finkelstein, L Spoerri, GD Ciccotosto, DK Wright, ...
Nature Medicine 18 (2), 291-295, 2012
Metallostasis in Alzheimer's disease
S Ayton, P Lei, AI Bush
Free Radical Biology and Medicine 62, 76-89, 2013
A delicate balance: iron metabolism and diseases of the brain
DJ Hare, S Ayton, AI Bush, P Lei
Frontiers in aging neuroscience 5, 34, 2013
Ceruloplasmin dysfunction and therapeutic potential for parkinson's disease
S Ayton, P Lei, JA Duce, BXW Wong, A Sedjahtera, PA Adlard, AI Bush, ...
Annals of Neurology, 2012
Tau protein: relevance to Parkinson's disease
P Lei, S Ayton, DI Finkelstein, PA Adlard, CL Masters, AI Bush
The international journal of biochemistry & cell biology 42 (11), 1775-1778, 2010
GSK-3 in neurodegenerative diseases
P Lei, S Ayton, AI Bush, PA Adlard
International Journal of Alzheimer’s Disease 2011, 2011
Sequestration of copper from β-amyloid promotes selective lysis by cyclen-hybrid cleavage agents
W Wu, P Lei, Q Liu, J Hu, AP Gunn, M Chen, Y Rui, X Su, Z Xie, YF Zhao, ...
Journal of Biological Chemistry 283 (46), 31657-31664, 2008
Characterization of copper binding to the peptide amyloid‐β (1–16) associated with Alzheimer's disease
QF Ma, J Hu, WH Wu, HD Liu, JT Du, Y Fu, YW Wu, P Lei, YF Zhao, YM Li
Biopolymers: Original Research on Biomolecules 83 (1), 20-31, 2006
Nigral iron elevation is an invariable feature of Parkinson’s disease and is a sufficient cause of neurodegeneration
S Ayton, P Lei
BioMed research international 2014, 2014
Biometals and their therapeutic implications in Alzheimer’s disease
S Ayton, P Lei, AI Bush
Neurotherapeutics 12 (1), 109-120, 2015
Tau-mediated iron export prevents ferroptotic damage after ischemic stroke
QZ Tuo, P Lei, KA Jackman, XL Li, H Xiong, ZY Liuyang, L Roisman, ...
Molecular psychiatry 22 (11), 1520-1530, 2017
An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta
DJ Hare, P Lei, S Ayton, BR Roberts, R Grimm, JL George, DP Bishop, ...
Chemical Science 5 (6), 2160-2169, 2014
Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein
S Ayton, P Lei, DJ Hare, JA Duce, JL George, PA Adlard, C McLean, ...
Journal of Neuroscience 35 (8), 3591-3597, 2015
Motor and cognitive deficits in aged tau knockout mice in two background strains
P Lei, S Ayton, S Moon, Q Zhang, I Volitakis, DI Finkelstein, AI Bush
Molecular neurodegeneration 9 (1), 29, 2014
Copper-induced cytotoxicity: reactive oxygen species or islet amyloid polypeptide oligomer formation
YP Yu, P Lei, J Hu, WH Wu, YF Zhao, YM Li
Chemical Communications 46 (37), 6909-6911, 2010
Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse
P Lei, S Ayton, AT Appukuttan, I Volitakis, PA Adlard, DI Finkelstein, ...
Neurobiology of disease 81, 168-175, 2015
Hydrogen peroxide can be generated by tau in the presence of Cu (II)
XY Su, WH Wu, ZP Huang, J Hu, P Lei, CH Yu, YF Zhao, YM Li
Biochemical and biophysical research communications 358 (2), 661-665, 2007
Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease
S Ayton, P Lei, PA Adlard, I Volitakis, RA Cherny, AI Bush, DI Finkelstein
Molecular neurodegeneration 9 (1), 27, 2014
Phosphorylation modulates the local conformation and self‐aggregation ability of a peptide from the fourth tau microtubule‐binding repeat
JT Du, CH Yu, LX Zhou, WH Wu, P Lei, Y Li, YF Zhao, H Nakanishi, YM Li
The FEBS journal 274 (19), 5012-5020, 2007
Insulin is a kinetic but not a thermodynamic inhibitor of amylin aggregation
W Cui, J Ma, P Lei, W Wu, Y Yu, Y Xiang, A Tong, Y Zhao, Y Li
The FEBS journal 276 (12), 3365-3371, 2009
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