|A randomized trial of protocol-based care for early septic shock|
New England Journal of Medicine 370 (18), 1683-1693, 2014
|Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial|
AE Jones, NI Shapiro, S Trzeciak, RC Arnold, HA Claremont, JA Kline, ...
Jama 303 (8), 739-746, 2010
|Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury|
K Kashani, A Al-Khafaji, T Ardiles, A Artigas, SM Bagshaw, M Bell, ...
Critical care 17 (1), 1-12, 2013
|Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality|
JH Kilgannon, AE Jones, NI Shapiro, MG Angelos, B Milcarek, K Hunter, ...
Jama 303 (21), 2165-2171, 2010
|Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network—United States, March–June 2020|
MW Tenforde, SS Kim, CJ Lindsell, E Billig Rose, NI Shapiro, DC Files, ...
Morbidity and Mortality Weekly Report 69 (30), 993-998, 2020
|Serum lactate as a predictor of mortality in emergency department patients with infection|
NI Shapiro, MD Howell, D Talmor, LA Nathanson, A Lisbon, RE Wolfe, ...
Annals of emergency medicine 45 (5), 524-528, 2005
|Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis|
RC Arnold, NI Shapiro, AE Jones, C Schorr, J Pope, E Casner, JE Parrillo, ...
Shock 32 (1), 35-39, 2009
|Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule|
NI Shapiro, RE Wolfe, RB Moore, E Smith, E Burdick, DW Bates
Critical care medicine 31 (3), 670-675, 2003
|National estimates of severe sepsis in United States emergency departments|
HE Wang, NI Shapiro, DC Angus, DM Yealy
Critical care medicine 35 (8), 1928-1936, 2007
|Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol|
NI Shapiro, MD Howell, D Talmor, D Lahey, L Ngo, J Buras, RE Wolfe, ...
Critical care medicine 34 (4), 1025-1032, 2006
|Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis|
S Trzeciak, JV McCoy, R Phillip Dellinger, RC Arnold, M Rizzuto, ...
Intensive care medicine 34 (12), 2210-2217, 2008
|Occult hypoperfusion and mortality in patients with suspected infection|
MD Howell, M Donnino, P Clardy, D Talmor, NI Shapiro
Intensive care medicine 33 (11), 1892-1899, 2007
|Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol|
MA Puskarich, S Trzeciak, NI Shapiro, RC Arnold, JM Horton, JR Studnek, ...
Critical care medicine 39 (9), 2066, 2011
|Demonstration of high‐fidelity simulation team training for emergency medicine|
SD Small, RC Wuerz, R Simon, N Shapiro, A Conn, G Setnik
Academic Emergency Medicine 6 (4), 312-323, 1999
|Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest|
JH Kilgannon, AE Jones, JE Parrillo, RP Dellinger, B Milcarek, K Hunter, ...
Circulation 123 (23), 2717-2722, 2011
|Diagnosing appendicitis: evidence-based review of the diagnostic approach in 2014|
DJ Shogilev, N Duus, SR Odom, NI Shapiro
Western Journal of Emergency Medicine 15 (7), 859, 2014
|Multicenter study of central venous oxygen saturation (ScvO2) as a predictor of mortality in patients with sepsis|
JV Pope, AE Jones, DF Gaieski, RC Arnold, S Trzeciak, NI Shapiro, ...
Annals of emergency medicine 55 (1), 40-46. e1, 2010
|The glycocalyx: a novel diagnostic and therapeutic target in sepsis|
R Uchimido, EP Schmidt, NI Shapiro
Critical care 23 (1), 1-12, 2019
|Effect of hydroxychloroquine on clinical status at 14 days in hospitalized patients with COVID-19: a randomized clinical trial|
WH Self, MW Semler, LM Leither, JD Casey, DC Angus, RG Brower, ...
Jama 324 (21), 2165-2176, 2020
|A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis|
NI Shapiro, S Trzeciak, JE Hollander, R Birkhahn, R Otero, TM Osborn, ...
Critical care medicine 37 (1), 96-104, 2009