Charles Chavkin
Charles Chavkin
Professor of Pharmacology, University of Washington
Verified email at - Homepage
Cited by
Cited by
Dynorphin is a specific endogenous ligand of the κ opioid receptor
C Chavkin, IF James, A Goldstein
Science 215 (4531), 413-415, 1982
Regulation of -opioid receptors: desensitization, phosphorylation, internalization, and tolerance
JT Williams, SL Ingram, G Henderson, C Chavkin, M von Zastrow, ...
Pharmacological reviews 65 (1), 223-254, 2013
Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
VM Navarro, ML Gottsch, C Chavkin, H Okamura, DK Clifton, RA Steiner
Journal of Neuroscience 29 (38), 11859-11866, 2009
Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus
S Impey, M Mark, EC Villacres, S Poser, C Chavkin, DR Storm
Neuron 16 (5), 973-982, 1996
The dysphoric component of stress is encoded by activation of the dynorphin κ-opioid system
BB Land, MR Bruchas, JC Lemos, M Xu, EJ Melief, C Chavkin
Journal of Neuroscience 28 (2), 407-414, 2008
Specific receptor for the opioid peptide dynorphin: structure--activity relationships.
C Chavkin, A Goldstein
Proceedings of the National Academy of Sciences 78 (10), 6543-6547, 1981
Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP
ST Wong, J Athos, XA Figueroa, VV Pineda, ML Schaefer, CC Chavkin, ...
Neuron 23 (4), 787-798, 1999
κ opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses
JP McLaughlin, M Marton-Popovici, C Chavkin
Journal of Neuroscience 23 (13), 5674-5683, 2003
The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
MR Bruchas, BB Land, C Chavkin
Brain research 1314, 44-55, 2010
Atrial G protein-activated K+ channel: expression cloning and molecular properties.
N Dascal, W Schreibmayer, NF Lim, W Wang, C Chavkin, L DiMagno, ...
Proceedings of the National Academy of Sciences 90 (21), 10235-10239, 1993
Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)
KM Crowder, JM Gunther, TA Jones, BD Hale, HZ Zhang, MR Peterson, ...
Proceedings of the National Academy of Sciences 96 (26), 15268-15273, 1999
Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice.
ZL Wu, SA Thomas, EC Villacres, Z Xia, ML Simmons, C Chavkin, ...
Proceedings of the National Academy of Sciences 92 (1), 220-224, 1995
Kinase cascades and ligand-directed signaling at the kappa opioid receptor
MR Bruchas, C Chavkin
Psychopharmacology 210, 137-147, 2010
Distinct domains of the CB1 cannabinoid receptor mediate desensitization and internalization
W Jin, S Brown, JP Roche, C Hsieh, JP Celver, A Kovoor, C Chavkin, ...
Journal of Neuroscience 19 (10), 3773-3780, 1999
Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive
JC Lemos, MJ Wanat, JS Smith, BAS Reyes, NG Hollon, ...
Nature 490 (7420), 402-406, 2012
Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking
BB Land, MR Bruchas, S Schattauer, WJ Giardino, M Aita, D Messinger, ...
Proceedings of the National Academy of Sciences 106 (45), 19168-19173, 2009
Stress-induced p38 mitogen-activated protein kinase activation mediates κ-opioid-dependent dysphoria
MR Bruchas, BB Land, M Aita, M Xu, SK Barot, S Li, C Chavkin
Journal of Neuroscience 27 (43), 11614-11623, 2007
Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus
JJ Wagner, GW Terman, C Chavkin
Nature 363 (6428), 451-454, 1993
Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction
MR Bruchas, AG Schindler, H Shankar, DI Messinger, M Miyatake, ...
Neuron 71 (3), 498-511, 2011
Kappa opioid receptor activation of p38 MAPK is GRK3-and arrestin-dependent in neurons and astrocytes
MR Bruchas, TA Macey, JD Lowe, C Chavkin
Journal of Biological Chemistry 281 (26), 18081-18089, 2006
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