Rami N Hannoush, Ph.D.
Rami N Hannoush, Ph.D.
Genentech, McGill, Harvard, Versant Ventures
Verified email at - Homepage
Cited by
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Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer
KD Proffitt, B Madan, Z Ke, V Pendharkar, L Ding, MA Lee, RN Hannoush, ...
Cancer research 73 (2), 502-507, 2013
Reconstitution of a Frizzled8· Wnt3a· LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
E Bourhis, C Tam, Y Franke, JF Bazan, J Ernst, J Hwang, M Costa, ...
Journal of Biological Chemistry 285 (12), 9172-9179, 2010
A caspase cascade regulating developmental axon degeneration
DJ Simon, RM Weimer, T McLaughlin, D Kallop, K Stanger, J Yang, ...
Journal of Neuroscience 32 (49), 17540-17553, 2012
Palmitoylation of TEAD transcription factors is required for their stability and function in Hippo pathway signaling
CL Noland, S Gierke, PD Schnier, J Murray, WN Sandoval, M Sagolla, ...
Structure 24 (1), 179-186, 2016
The chemical toolbox for monitoring protein fatty acylation and prenylation
RN Hannoush, JL Sun
Nature chemical biology 6 (7), 498-506, 2010
Inhibition of Wnt signaling by Dishevelled PDZ peptides
Y Zhang, BA Appleton, C Wiesmann, T Lau, M Costa, RN Hannoush, ...
Nature chemical biology 5 (4), 217-219, 2009
Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine
X Gao, RN Hannoush
Nature chemical biology 10 (1), 61-68, 2014
Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs
JP Dijksterhuis, B Baljinnyam, K Stanger, HO Sercan, Y Ji, O Andres, ...
Journal of Biological Chemistry 290 (11), 6789-6798, 2015
Imaging the lipidome: ω-alkynyl fatty acids for detection and cellular visualization of lipid-modified proteins
RN Hannoush, N Arenas-Ramirez
ACS chemical biology 4 (7), 581-587, 2009
Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies
Y Gong, E Bourhis, C Chiu, S Stawicki, VI DeAlmeida, BY Liu, ...
PloS one 5 (9), e12682, 2010
Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6
E Bourhis, W Wang, C Tam, J Hwang, Y Zhang, D Spittler, OW Huang, ...
Structure 19 (10), 1433-1442, 2011
The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins
K Suryamohan, SP Krishnankutty, J Guillory, M Jevit, MS Schröder, M Wu, ...
Nature Genetics 52 (1), 106-117, 2020
Regulation of the oncoprotein Smoothened by small molecules
HJ Sharpe, W Wang, RN Hannoush, FJ De Sauvage
Nature chemical biology 11 (4), 246-255, 2015
Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling
XD Huang, JC McGann, BY Liu, RN Hannoush, JR Lill, V Pham, ...
Science 339 (6126), 1441-1445, 2013
Engineering and structural characterization of a linear polyubiquitin-specific antibody
ML Matsumoto, KC Dong, C Yu, L Phu, X Gao, RN Hannoush, ...
Journal of molecular biology 418 (3-4), 134-144, 2012
Fatty acylation of Wnt proteins
AH Nile, RN Hannoush
Nature chemical biology 12 (2), 60-69, 2016
Scalable total synthesis and biological evaluation of haouamine A and its atropisomer
NZ Burns, IN Krylova, RN Hannoush, PS Baran
Journal of the American Chemical Society 131 (26), 9172-9173, 2009
Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding
AH Nile, S Mukund, K Stanger, W Wang, RN Hannoush
Proceedings of the National Academy of Sciences 114 (16), 4147-4152, 2017
Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors
BC Goess, RN Hannoush, LK Chan, T Kirchhausen, MD Shair
Journal of the American Chemical Society 128 (16), 5391-5403, 2006
A decade of click chemistry in protein palmitoylation: impact on discovery and new biology
X Gao, RN Hannoush
Cell chemical biology 25 (3), 236-246, 2018
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