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David Farrens
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Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
DL Farrens, C Altenbach, K Yang, WL Hubbell, HG Khorana
science 274 (5288), 768-770, 1996
15331996
Functionally different agonists induce distinct conformations in the G protein coupling domain of the β2Adrenergic receptor
P Ghanouni, Z Gryczynski, JJ Steenhuis, TW Lee, DL Farrens, ...
Journal of Biological Chemistry 276 (27), 24433-24436, 2001
4782001
Agonist-induced conformational changes in the G-protein-coupling domain of the β2 adrenergic receptor
P Ghanouni, JJ Steenhuis, DL Farrens, BK Kobilka
Proceedings of the National Academy of Sciences 98 (11), 5997-6002, 2001
4392001
Coupling ligand structure to specific conformational switches in the β2-adrenoceptor
X Yao, C Parnot, X Deupi, VRP Ratnala, G Swaminath, D Farrens, ...
Nature chemical biology 2 (8), 417-422, 2006
4272006
Structural features and light-dependent changes in the cytoplasmic interhelical E− F loop region of rhodopsin: a site-directed spin-labeling study
C Altenbach, K Yang, DL Farrens, ZT Farahbakhsh, HG Khorana, ...
Biochemistry 35 (38), 12470-12478, 1996
3881996
Biosensor reveals multiple sources for mitochondrial NAD+
XA Cambronne, ML Stewart, DH Kim, AM Jones-Brunette, RK Morgan, ...
Science 352 (6292), 1474-1477, 2016
3522016
Structure of a signaling cannabinoid receptor 1-G protein complex
KK Kumar, M Shalev-Benami, MJ Robertson, H Hu, SD Banister, ...
Cell 176 (3), 448-458. e12, 2019
3432019
Domains responsible for constitutive and Ca2+-dependent interactions between calmodulin and small conductance Ca2+-activated potassium channels
JE Keen, R Khawaled, DL Farrens, T Neelands, A Rivard, CT Bond, ...
Journal of Neuroscience 19 (20), 8830-8838, 1999
2831999
Structure and Function in Rhodopsin: MEASUREMENT OF THE RATE OF METARHODOPSIN II DECAY BY FLUORESCENCE SPECTROSCOPY (∗)
DL Farrens, HG Khorana
Journal of Biological Chemistry 270 (10), 5073-5076, 1995
2291995
Conformational changes in rhodopsin: movement of helix F detected by site-specific chemical labeling and fluorescence spectroscopy
TD Dunham, DL Farrens
Journal of Biological Chemistry 274 (3), 1683-1690, 1999
2171999
Rhodopsin activation exposes a key hydrophobic binding site for the transducin α-subunit C terminus
JM Janz, DL Farrens
Journal of Biological Chemistry 279 (28), 29767-29773, 2004
1392004
Structure and function in rhodopsin. Single cysteine substitution mutants in the cytoplasmic interhelical E− F loop region show position-specific effects in transducin activation
K Yang, DL Farrens, WL Hubbell, HG Khorana
Biochemistry 35 (38), 12464-12469, 1996
1271996
Structure and function in rhodopsin. Cysteines 65 and 316 are in proximity in a rhodopsin mutant as indicated by disulfide formation and interactions between attached spin labels
K Yang, DL Farrens, C Altenbach, ZT Farahbakhsh, WL Hubbell, ...
Biochemistry 35 (45), 14040-14046, 1996
1261996
Mapping proximity within proteins using fluorescence spectroscopy. A study of T4 lysozyme showing that tryptophan residues quench bimane fluorescence
SE Mansoor, HS Mchaourab, DL Farrens
Biochemistry 41 (8), 2475-2484, 2002
1212002
Rhodopsin self-associates in asolectin liposomes
SE Mansoor, K Palczewski, DL Farrens
Proceedings of the National Academy of Sciences 103 (9), 3060-3065, 2006
1162006
Monomeric rhodopsin is the minimal functional unit required for arrestin binding
H Tsukamoto, A Sinha, M DeWitt, DL Farrens
Journal of molecular biology 399 (3), 501-511, 2010
1142010
Distance mapping in proteins using fluorescence spectroscopy: the tryptophan-induced quenching (TrIQ) method
SE Mansoor, MA DeWitt, DL Farrens
Biochemistry 49 (45), 9722-9731, 2010
1052010
Stability of dark state rhodopsin is mediated by a conserved ion pair in intradiscal loop E-2
JM Janz, JF Fay, DL Farrens
Journal of Biological Chemistry 278 (19), 16982-16991, 2003
1032003
Single-cysteine substitution mutants at amino acid positions 306− 321 in rhodopsin, the sequence between the cytoplasmic end of helix VII and the palmitoylation sites …
K Cai, J Klein-Seetharaman, D Farrens, C Zhang, C Altenbach, ...
Biochemistry 38 (25), 7925-7930, 1999
981999
Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties
JC Craig, MA Schumacher, SE Mansoor, DL Farrens, RG Brennan, ...
Journal of Biological Chemistry 276 (15), 11719-11728, 2001
962001
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