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| Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen Y Chen, C Wiesmann, G Fuh, B Li, HW Christinger, P McKay, AM de Vos, ... Journal of molecular biology 293 (4), 865-881, 1999 | 1126 | 1999 |
| The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective … AJ Folkes, K Ahmadi, WK Alderton, S Alix, SJ Baker, G Box, ... Journal of medicinal chemistry 51 (18), 5522-5532, 2008 | 849 | 2008 |
| Crystal structure at 1.7 Å resolution of VEGF in complex with domain 2 of the Flt-1 receptor C Wiesmann, G Fuh, HW Christinger, C Eigenbrot, JA Wells, AM de Vos Cell 91 (5), 695-704, 1997 | 689 | 1997 |
| Allosteric inhibition of protein tyrosine phosphatase 1B C Wiesmann, KJ Barr, J Kung, J Zhu, DA Erlanson, W Shen, BJ Fahr, ... Nature structural & molecular biology 11 (8), 730-737, 2004 | 561 | 2004 |
| Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor C Wiesmann, MH Ultsch, SH Bass, AM de Vos Nature 401 (6749), 184-188, 1999 | 552 | 1999 |
| The discovery of first-in-class drugs: origins and evolution J Eder, R Sedrani, C Wiesmann Nature Reviews Drug Discovery 13 (8), 577-587, 2014 | 551 | 2014 |
| Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site J Bostrom, SF Yu, D Kan, BA Appleton, CV Lee, K Billeci, W Man, F Peale, ... Science 323 (5921), 1610-1614, 2009 | 473 | 2009 |
| Synthetic antibodies from a four-amino-acid code: a dominant role for tyrosine in antigen recognition FA Fellouse, C Wiesmann, SS Sidhu Proceedings of the National Academy of Sciences 101 (34), 12467-12472, 2004 | 461 | 2004 |
| High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries FA Fellouse, K Esaki, S Birtalan, D Raptis, VJ Cancasci, A Koide, ... Journal of molecular biology 373 (4), 924-940, 2007 | 450 | 2007 |
| Macrophage complement receptors and pathogen clearance M van Lookeren Campagne, C Wiesmann, EJ Brown Cellular microbiology 9 (9), 2095-2102, 2007 | 407 | 2007 |
| Cryo-EM in drug discovery: achievements, limitations and prospects JP Renaud, A Chari, C Ciferri, W Liu, HW Rémigy, H Stark, C Wiesmann Nature reviews Drug discovery 17 (7), 471-492, 2018 | 400 | 2018 |
| Mechanism of MEK inhibition determines efficacy in mutant KRAS-versus BRAF-driven cancers G Hatzivassiliou, JR Haling, H Chen, K Song, S Price, R Heald, ... Nature 501 (7466), 232-236, 2013 | 330 | 2013 |
| Crystal structure of the HGF β‐chain in complex with the Sema domain of the Met receptor J Stamos, RA Lazarus, X Yao, D Kirchhofer, C Wiesmann The EMBO journal 23 (12), 2325-2335, 2004 | 307 | 2004 |
| Nerve growth factor: structure and function C Wiesmann, AM De Vos Cellular and Molecular Life Sciences CMLS 58, 748-759, 2001 | 302 | 2001 |
| Antibody-based targeting of FGFR3 in bladder carcinoma and t (4; 14)-positive multiple myeloma in mice J Qing, X Du, Y Chen, P Chan, H Li, P Wu, S Marsters, S Stawicki, J Tien, ... The Journal of clinical investigation 119 (5), 1216-1229, 2009 | 295 | 2009 |
| Structure of C3b in complex with CRIg gives insights into regulation of complement activation C Wiesmann, KJ Katschke, JP Yin, KY Helmy, M Steffek, WJ Fairbrother, ... Nature 444 (7116), 217-220, 2006 | 283 | 2006 |
| Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC MH Ultsch, C Wiesmann, LC Simmons, J Henrich, M Yang, D Reilly, ... Journal of molecular biology 290 (1), 149-159, 1999 | 260 | 1999 |
| Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors—insight into heterotrimeric IL-1 signaling complexes A Lingel, TM Weiss, M Niebuhr, B Pan, BA Appleton, C Wiesmann, ... Structure 17 (10), 1398-1410, 2009 | 256 | 2009 |
| Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding BA Appleton, P Wu, J Maloney, JP Yin, WC Liang, S Stawicki, K Mortara, ... The EMBO journal 26 (23), 4902-4912, 2007 | 253 | 2007 |
