Genomically Recoded Organisms Expand Biological Functions MJ Lajoie, AJ Rovner, DB Goodman, HR Aerni, AD Haimovich, ... Science 342 (6156), 357-360, 2013 | 977 | 2013 |
Precise manipulation of chromosomes in vivo enables genome-wide codon replacement FJ Isaacs, PA Carr, HH Wang, MJ Lajoie, B Sterling, L Kraal, AC Tolonen, ... Science 333 (6040), 348-353, 2011 | 678 | 2011 |
Biocontainment of genetically modified organisms by synthetic protein design DJ Mandell, MJ Lajoie, MT Mee, R Takeuchi, G Kuznetsov, JE Norville, ... Nature 518 (7537), 55-60, 2015 | 496 | 2015 |
Design, synthesis, and testing toward a 57-codon genome N Ostrov, M Landon, M Guell, G Kuznetsov, J Teramoto, N Cervantes, ... Science 353 (6301), 819-822, 2016 | 364 | 2016 |
The genome project-write JD Boeke, G Church, A Hessel, NJ Kelley, A Arkin, Y Cai, R Carlson, ... Science 353 (6295), 126-127, 2016 | 286 | 2016 |
Lambda red recombineering in Escherichia coli occurs through a fully single-stranded intermediate JA Mosberg, MJ Lajoie, GM Church Genetics 186 (3), 791-799, 2010 | 274 | 2010 |
De novo design of bioactive protein switches RA Langan, SE Boyken, AH Ng, JA Samson, G Dods, AM Westbrook, ... Nature 572 (7768), 205-210, 2019 | 271 | 2019 |
Evolution of a designed protein assembly encapsulating its own RNA genome GL Butterfield, MJ Lajoie, HH Gustafson, DL Sellers, U Nattermann, ... Nature 552 (7685), 415-420, 2017 | 224 | 2017 |
De novo design of modular and tunable protein biosensors A Quijano-Rubio, HW Yeh, J Park, H Lee, RA Langan, SE Boyken, ... Nature 591 (7850), 482-487, 2021 | 200 | 2021 |
Codon usage of highly expressed genes affects proteome-wide translation efficiency I Frumkin, MJ Lajoie, CJ Gregg, G Hornung, GM Church, Y Pilpel Proceedings of the National Academy of Sciences 115 (21), E4940-E4949, 2018 | 200 | 2018 |
Probing the Limits of Genetic Recoding in Essential Genes MJ Lajoie, S Kosuri, JA Mosberg, CJ Gregg, D Zhang, GM Church science 342 (6156), 361-363, 2013 | 172 | 2013 |
Rewriting the genetic code T Mukai, MJ Lajoie, M Englert, D Söll Annual review of microbiology 71, 557-577, 2017 | 168 | 2017 |
Designed protein logic to target cells with precise combinations of surface antigens MJ Lajoie, SE Boyken, AI Salter, J Bruffey, A Rajan, RA Langan, ... Science 369 (6511), 1637-1643, 2020 | 163 | 2020 |
An orthogonalized platform for genetic code expansion in both bacteria and eukaryotes JS Italia, PS Addy, CJJ Wrobel, LA Crawford, MJ Lajoie, Y Zheng, ... Nature Chemical Biology 13 (4), 446-450, 2017 | 136 | 2017 |
Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection PA Carr, HH Wang, B Sterling, FJ Isaacs, MJ Lajoie, G Xu, GM Church, ... Nucleic Acids Research 40 (17), e132-e132, 2012 | 132 | 2012 |
Improved bacterial recombineering by parallelized protein discovery TM Wannier, A Nyerges, HM Kuchwara, M Czikkely, D Balogh, ... Proceedings of the National Academy of Sciences, 2020 | 120 | 2020 |
Improving Lambda Red Genome Engineering in Escherichia coli via Rational Removal of Endogenous Nucleases JA Mosberg, CJ Gregg, MJ Lajoie, HH Wang, GM Church PloS one 7 (9), e44638, 2012 | 116 | 2012 |
Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents T Honda, H Yoshizawa, C Sundararajan, E David, MJ Lajoie, ... Journal of medicinal chemistry 54 (6), 1762-1778, 2011 | 78 | 2011 |
Emergent rules for codon choice elucidated by editing rare arginine codons in Escherichia coli MG Napolitano, M Landon, CJ Gregg, MJ Lajoie, L Govindarajan, ... Proceedings of the National Academy of Sciences 113 (38), E5588-E5597, 2016 | 75 | 2016 |
Overcoming challenges in engineering the genetic code MJ Lajoie, D Söll, GM Church Journal of molecular biology 428 (5), 1004-1021, 2016 | 72 | 2016 |