Sang Hyun Lee
Sang Hyun Lee
Duke-NUS Graduate Medical School Singapore
Verified email at - Homepage
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A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
H Okabe, SH Lee, J Phuchareon, DG Albertson, F McCormick, O Tetsu
PloS one 1 (1), e128, 2006
Tpr directly binds to Mad1 and Mad2 and is important for the Mad1–Mad2-mediated mitotic spindle checkpoint
SH Lee, H Sterling, A Burlingame, F McCormick
Genes & development 22 (21), 2926-2931, 2008
Pharmacologic inhibition of RAF→ MEK→ ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1
S Gysin, SH Lee, NM Dean, M McMahon
Cancer research 65 (11), 4870-4880, 2005
The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis
T Utermark, T Rao, H Cheng, Q Wang, SH Lee, ZC Wang, JD Iglehart, ...
Genes & development 26 (14), 1573-1586, 2012
IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ϵ and Wnt/β-catenin independent inhibition of mitotic spindle formation
JK Cheong, NT Hung, H Wang, P Tan, PM Voorhoeve, SH Lee, ...
Oncogene 30 (22), 2558-2569, 2011
The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis
M Kitagawa, SH Lee
Frontiers in cell and developmental biology 3, 14, 2015
p97/DAP5 is a ribosome‐associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins
SH Lee, F McCormick
The EMBO journal 25 (17), 4008-4019, 2006
Skp2 suppresses p53-dependent apoptosis by inhibiting p300
M *Kitagawa, SH *Lee, F McCormick, (* co-first)
Molecular cell 29 (2), 217-231, 2008
BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression
P Xu, EA Raetz, M Kitagawa, DM Virshup, SH Lee
Biology open 2 (5), 479-486, 2013
Characterization of the nuclear import and export functions of IκBε
SH Lee, M Hannink
Journal of Biological Chemistry 277 (26), 23358-23366, 2002
E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines
M Kitagawa, M Aonuma, SH Lee, S Fukutake, F McCormick
Oncogene 27 (40), 5303-5314, 2008
Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization
J Wang, Z Wang, T Yu, H Yang, DM Virshup, GJPL Kops, SH Lee, W Zhou, ...
Protein & cell 7 (7), 516-526, 2016
Cdk1 coordinates timely activation of MKlp2 kinesin with relocation of the chromosome passenger complex for cytokinesis
M Kitagawa, SYS Fung, UFS Hameed, H Goto, M Inagaki, SH Lee
Cell reports 7 (1), 166-179, 2014
Targeting Aurora B to the equatorial cortex by MKlp2 is required for cytokinesis
M Kitagawa, SYS Fung, N Onishi, H Saya, SH Lee
PloS one 8 (6), e64826, 2013
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality
M Kitagawa, PJ Liao, KH Lee, J Wong, SC Shang, N Minami, ...
Nature communications 8 (1), 2200, 2017
Downregulation of Skp2 and p27/Kip1 synergistically induces apoptosis in T98G glioblastoma cells
SH Lee, F McCormick
Journal of molecular medicine 83, 296-307, 2005
Molecular mechanisms that regulate transcription factor localization suggest new targets for drug development
SH Lee, M Hannink
Advanced drug delivery reviews 55 (6), 717-731, 2003
TRIM28 is an E3 ligase for ARF-mediated NPM1/B23 SUMOylation that represses centrosome amplification
SH Neo, Y Itahana, J Alagu, M Kitagawa, AK Guo, SH Lee, K Tang, ...
Molecular and cellular biology 35 (16), 2851-2863, 2015
Mad2 inhibits the mitotic kinesin MKlp2
SH Lee, F McCormick, H Saya
Journal of cell biology 191 (6), 1069-1077, 2010
The N-terminal nuclear export sequence of IκBα is required for RanGTP-dependent binding to CRM1
SH Lee, M Hannink
Journal of Biological Chemistry 276 (26), 23599-23606, 2001
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