Lewis Cantley

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John AsaraAssociate Professor Medicine, Harvard Medical School; Director, Beth Israel Deaconess Medical CenterVerified email at bidmc.harvard.edu
Costas LyssiotisProfessor of Physiology, University of MichiganVerified email at lyssiotis.com
Ji LuoNational Cancer InstituteVerified email at nih.gov
David FrumanProfessor of Molecular Biology & Biochemistry, UC IrvineVerified email at uci.edu
John BlenisProfessor of Pharmacology, Weill Cornell MedicineVerified email at med.cornell.edu
Alex TokerVerified email at bidmc.harvard.edu
Jason LocasaleDuke UniversityVerified email at alum.mit.edu
Brendan D. ManningHarvard UniversityVerified email at hsph.harvard.edu
Lucia Rameh PlantVanderbilt UniversityVerified email at vanderbilt.edu
C. Ronald KahnJoslin Diabetes Center and Harvard Medical SchoolVerified email at joslin.harvard.edu
Reuben ShawThe Salk Institute of Biological StudiesVerified email at salk.edu
Pier Paolo PandolfiDirector, Cancer Center and Cancer Research Institute, Beth Israel Deaconess Medical CenterVerified email at bidmc.harvard.edu
Ronald A. DePinhoMD AndersonVerified email at mdanderson.org
David R. KaplanHospital for Sick ChildrenVerified email at sickkids.ca
Steven ShoelsonHarvard Medical SchoolVerified email at joslin.harvard.edu
Gerburg WulfAssociate Professor in Medicine, Harvard Medical SchoolVerified email at bidmc.harvard.edu
Kurt AugerGSKVerified email at gsk.com
Pasi JanneDana Farber Cancer InstituteVerified email at dfci.harvard.edu
Malcolm WhitmanHarvardVerified email at hms.harvard.edu
Marcus D GoncalvesWeill Cornell New York Presbyterian HospitalVerified email at med.cornell.edu

Lewis Cantley

Dana Farber Cancer Center and Harvard Medical School

Verified email at med.cornell.edu

cancer metabolism signal transduction PI 3-Kinase Protein kinases


Title Sort by citations Sort by year Sort by title	Cited by Cited by	Year
Understanding the Warburg effect: the metabolic requirements of cell proliferation MG Vander Heiden, LC Cantley, CB Thompson science 324 (5930), 1029-1033, 2009	16916	2009
AKT/PKB signaling: navigating downstream BD Manning, LC Cantley Cell 129 (7), 1261-1274, 2007	7446	2007
The phosphoinositide 3-kinase pathway LC Cantley Science 296 (5573), 1655-1657, 2002	7363	2002
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling JA Engelman, K Zejnullahu, T Mitsudomi, Y Song, C Hyland, JO Park, ... science 316 (5827), 1039-1043, 2007	5505	2007
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate L Dang, DW White, S Gross, BD Bennett, MA Bittinger, EM Driggers, ... Nature 462 (7274), 739-744, 2009	4746	2009
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism JA Engelman, J Luo, LC Cantley Nature Reviews Genetics 7 (8), 606-619, 2006	4022	2006
Oncogenes and signal transduction LC Cantley, KR Auger, C Carpenter, B Duckworth, A Graziani, R Kapeller, ... Cell 64 (2), 281-302, 1991	3579	1991
SH2 domains recognize specific phosphopeptide sequences S Zhou, SE Shoelson, M Chaudhuri, G Gish, T Pawson, WG Haser, F King, ... Cell 72 (5), 767-778, 1993	3571	1993
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth HR Christofk, MG Vander Heiden, MH Harris, A Ramanathan, ... Nature 452 (7184), 230-233, 2008	3222	2008
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis GM DeNicola, FA Karreth, TJ Humpton, A Gopinathan, C Wei, K Frese, ... Nature 475 (7354), 106-109, 2011	2860*	2011
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway LC Cantley, BG Neel Proceedings of the National Academy of Sciences 96 (8), 4240-4245, 1999	2759	1999
Ras, PI (3) K and mTOR signalling controls tumour cell growth RJ Shaw, LC Cantley Nature 441 (7092), 424-430, 2006	2659	2006
PI3K pathway alterations in cancer: variations on a theme TL Yuan, LC Cantley Oncogene 27 (41), 5497-5510, 2008	2405	2008
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin RJ Shaw, KA Lamia, D Vasquez, SH Koo, N Bardeesy, RA DePinho, ... Science 310 (5754), 1642-1646, 2005	2394	2005
The PI3K pathway in human disease DA Fruman, H Chiu, BD Hopkins, S Bagrodia, LC Cantley, RT Abraham Cell 170 (4), 605-635, 2017	2317	2017
PI3K: downstream AKTion blocks apoptosis TF Franke, DR Kaplan, LC Cantley Cell 88 (4), 435-437, 1997	2201	1997
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress RJ Shaw, M Kosmatka, N Bardeesy, RL Hurley, LA Witters, RA DePinho, ... Proceedings of the National Academy of Sciences 101 (10), 3329-3335, 2004	2162	2004
Phosphoinositide kinases DA Fruman, RE Meyers, LC Cantley Annual review of biochemistry 67 (1), 481-507, 1998	2132	1998
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ... Cell 149 (3), 656-670, 2012	2047	2012
The structural basis for 14-3-3: phosphopeptide binding specificity MB Yaffe, K Rittinger, S Volinia, PR Caron, A Aitken, H Leffers, ... Cell 91 (7), 961-971, 1997	2013	1997

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