| How does a drug molecule find its target binding site? Y Shan, ET Kim, MP Eastwood, RO Dror, MA Seeliger, DE Shaw Journal of the American Chemical Society 133 (24), 9181-9183, 2011 | 668 | 2011 |
| Activation of tyrosine kinases by mutation of the gatekeeper threonine M Azam, MA Seeliger, NS Gray, J Kuriyan, GQ Daley Nature structural & molecular biology 15 (10), 1109-1118, 2008 | 493 | 2008 |
| Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680 MA Young, NP Shah, LH Chao, M Seeliger, ZV Milanov, WH Biggs III, ... Cancer research 66 (2), 1007-1014, 2006 | 350 | 2006 |
| Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms N Jura, X Zhang, NF Endres, MA Seeliger, T Schindler, J Kuriyan Molecular cell 42 (1), 9-22, 2011 | 335 | 2011 |
| A conserved protonation-dependent switch controls drug binding in the Abl kinase Y Shan, MA Seeliger, MP Eastwood, F Frank, H Xu, MØ Jensen, RO Dror, ... Proceedings of the National Academy of Sciences 106 (1), 139-144, 2009 | 289 | 2009 |
| High yield bacterial expression of active c‐Abl and c‐Src tyrosine kinases MA Seeliger, M Young, MN Henderson, P Pellicena, DS King, AM Falick, ... Protein Science 14 (12), 3135-3139, 2005 | 275 | 2005 |
| Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones JP Maianti, A McFedries, ZH Foda, RE Kleiner, XQ Du, MA Leissring, ... Nature 511 (7507), 94-98, 2014 | 267 | 2014 |
| A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export B Montpetit, ND Thomsen, KJ Helmke, MA Seeliger, JM Berger, K Weis Nature 472 (7342), 238-242, 2011 | 261 | 2011 |
| c-Src binds to the cancer drug imatinib with an inactive Abl/c-Kit conformation and a distributed thermodynamic penalty MA Seeliger, B Nagar, F Frank, X Cao, MN Henderson, J Kuriyan Structure 15 (3), 299-311, 2007 | 261 | 2007 |
| Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase B Nagar, O Hantschel, M Seeliger, JM Davies, WI Weis, G Superti-Furga, ... Molecular cell 21 (6), 787-798, 2006 | 255 | 2006 |
| Mechanism of CDK5/p25 binding by CDK inhibitors M Mapelli, L Massimiliano, C Crovace, MA Seeliger, LH Tsai, L Meijer, ... Journal of medicinal chemistry 48 (3), 671-679, 2005 | 246 | 2005 |
| Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors L Wang, BGK Perera, SB Hari, B Bhhatarai, BJ Backes, MA Seeliger, ... Nature chemical biology 8 (12), 982-989, 2012 | 228 | 2012 |
| Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations MA Seeliger, P Ranjitkar, C Kasap, Y Shan, DE Shaw, NP Shah, ... Cancer research 69 (6), 2384-2392, 2009 | 185 | 2009 |
| Structural basis for the recognition of c-Src by its inactivator Csk NM Levinson, MA Seeliger, PA Cole, J Kuriyan Cell 134 (1), 124-134, 2008 | 145 | 2008 |
| Three different binding sites of Cks1 are required for p27-ubiquitin ligation D Sitry, MA Seeliger, TK Ko, D Ganoth, SE Breward, LS Itzhaki, M Pagano, ... Journal of Biological Chemistry 277 (44), 42233-42240, 2002 | 131 | 2002 |
| A dynamically coupled allosteric network underlies binding cooperativity in Src kinase ZH Foda, Y Shan, ET Kim, DE Shaw, MA Seeliger Nature communications 6 (1), 5939, 2015 | 121 | 2015 |
| Targeting conformational plasticity of protein kinases M Tong, MA Seeliger ACS chemical biology 10 (1), 190-200, 2015 | 114 | 2015 |
| Structural and functional analysis of the allosteric inhibition of IRE1α with ATP-competitive ligands HC Feldman, M Tong, L Wang, R Meza-Acevedo, TA Gobillot, I Lebedev, ... ACS chemical biology 11 (8), 2195-2205, 2016 | 96 | 2016 |
| Tuning a three-component reaction for trapping kinase substrate complexes AV Statsuk, DJ Maly, MA Seeliger, MA Fabian, WH Biggs III, DJ Lockhart, ... Journal of the American Chemical Society 130 (51), 17568-17574, 2008 | 88 | 2008 |
| Fibronectin interaction and enhancement of growth factors: importance for wound healing KM Sawicka, M Seeliger, T Musaev, LK Macri, RAF Clark Advances in wound care 4 (8), 469-478, 2015 | 84 | 2015 |
John KuriyanProfessor of Molecular and Cell Biology and ChemistryVerified email at berkeley.edu
