David M. Sabatini

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Tim WangHelen Hay Whitney Fellow, Janelia Research CampusVerified email at janelia.hhmi.org
Kivanc BirsoyChapman-Perelman Assistant Professor, Rockefeller UniversityVerified email at rockefeller.edu
Roberto ZoncuUniversity of California BerkeleyVerified email at berkeley.edu
Mathieu LaplanteUniversité LavalVerified email at criucpq.ulaval.ca
Nathanael GrayProfessor of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolVerified email at dfci.harvard.edu
Anne E. CarpenterInstitute Scientist and Imaging Platform Director, Broad Institute of Harvard and MITVerified email at broadinstitute.org
Dudley LammingAssociate Professor of Medicine, University of Wisconsin-MadisonVerified email at medicine.wisc.edu
Do-Hyung KimUniversity of Minnesota - MinneapolisVerified email at umn.edu
Monther Abu-RemailehStanford UniversityVerified email at stanford.edu
Elizaveta (Lisa) FreinkmanSenior R&D Project Manager, Locus BiosciencesVerified email at locus-bio.com
Robert A. SaxtonAssistant Professor, UC BerkeleyVerified email at berkeley.edu
Richard PossematoAssociate Professor, NYU School of MedicineVerified email at nyulangone.org
Solomon H SnyderJohns HopkinsVerified email at jhmi.edu
David E. RootBroad InstituteVerified email at broadinstitute.org
Kuang ShenAssistant Professor, UMass Medical SchoolVerified email at umassmed.edu
Hediye Erdjument-BromageProteomics Core Manager, Memorial Sloan-Kettering Cancer Center, New York, NY, USAVerified email at ski.mskcc.org
Jason MoffatSenior Scientist & Program Head, Genetics & Genome Biology, Sickkids Hospital; Professor, UofTVerified email at utoronto.ca
Shomit SenguptaSenior Director, Atavistik BioVerified email at atavistikbio.com
Pekka KatajistoUniversity of Helsinki and Karolinska InstitutetVerified email at helsinki.fi
Omer YilmazMassachusetts Institute of TechnologyVerified email at mit.edu

David M. Sabatini

Whitehead Institute/MIT/HHMI

Verified email at wi.mit.edu - Homepage

mTOR rapamycin growth nutrients metabolism


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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹ DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021	12021*	2021
mTOR signaling in growth control and disease M Laplante, DM Sabatini cell 149 (2), 274-293, 2012	8752	2012
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex DD Sarbassov, DA Guertin, SM Ali, DM Sabatini Science 307 (5712), 1098-1101, 2005	7957	2005
mTOR signaling in growth, metabolism, and disease RA Saxton, DM Sabatini Cell 168 (6), 960-976, 2017	6026	2017
CellProfiler: image analysis software for identifying and quantifying cell phenotypes AE Carpenter, TR Jones, MR Lamprecht, C Clarke, IH Kang, O Friman, ... Genome biology 7, 1-11, 2006	5100	2006
mTOR: from growth signal integration to cancer, diabetes and ageing R Zoncu, A Efeyan, DM Sabatini Nature reviews Molecular cell biology 12 (1), 21-35, 2011	4489	2011
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery DH Kim, DD Sarbassov, SM Ali, JE King, RR Latek, ... Cell 110 (2), 163-175, 2002	3506	2002
Defining the role of mTOR in cancer DA Guertin, DM Sabatini Cancer cell 12 (1), 9-22, 2007	3405	2007
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton DD Sarbassov, SM Ali, DH Kim, DA Guertin, RR Latek, ... Current biology 14 (14), 1296-1302, 2004	3230	2004
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB DD Sarbassov, SM Ali, S Sengupta, JH Sheen, PP Hsu, AF Bagley, ... Molecular cell 22 (2), 159-168, 2006	3139	2006
Genetic screens in human cells using the CRISPR-Cas9 system T Wang, JJ Wei, DM Sabatini, ES Lander Science 343 (6166), 80-84, 2014	2992	2014
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 Y Sancak, TR Peterson, YD Shaul, RA Lindquist, CC Thoreen, ... Science 320 (5882), 1496-1501, 2008	2858	2008
Cancer cell metabolism: Warburg and beyond PP Hsu, DM Sabatini Cell 134 (5), 703-707, 2008	2660	2008
mTOR signaling at a glance M Laplante, DM Sabatini Journal of cell science 122 (20), 3589-3594, 2009	2647	2009
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 DA Barbie, P Tamayo, JS Boehm, SY Kim, SE Moody, IF Dunn, ... Nature 462 (7269), 108-112, 2009	2622	2009
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids Y Sancak, L Bar-Peled, R Zoncu, AL Markhard, S Nada, DM Sabatini Cell 141 (2), 290-303, 2010	2460	2010
Growing roles for the mTOR pathway DD Sarbassov, SM Ali, DM Sabatini Current opinion in cell biology 17 (6), 596-603, 2005	1947	2005
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen J Moffat, DA Grueneberg, X Yang, SY Kim, AM Kloepfer, G Hinkle, ... Cell 124 (6), 1283-1298, 2006	1944	2006
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 CC Thoreen, SA Kang, JW Chang, Q Liu, J Zhang, Y Gao, LJ Reichling, ... Journal of Biological Chemistry 284 (12), 8023-8032, 2009	1928	2009
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs DM Sabatini, H Erdjument-Bromage, M Lui, P Tempst, SH Snyder Cell 78 (1), 35-43, 1994	1885	1994

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