David M. Sabatini

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Tim WangHelen Hay Whitney Fellow, Janelia Research CampusVerified email at janelia.hhmi.org
Kivanc BirsoyChapman-Perelman Associate Professor, Rockefeller UniversityVerified email at rockefeller.edu
Roberto ZoncuUniversity of California BerkeleyVerified email at berkeley.edu
Mathieu LaplanteUniversité LavalVerified email at criucpq.ulaval.ca
Nathanael GrayProfessor of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolVerified email at dfci.harvard.edu
Anne E. CarpenterInstitute Scientist and Imaging Platform Director, Broad Institute of Harvard and MITVerified email at broadinstitute.org
Dudley LammingAssociate Professor of Medicine, University of Wisconsin-MadisonVerified email at medicine.wisc.edu
Do-Hyung KimUniversity of Minnesota - MinneapolisVerified email at umn.edu
Monther Abu-RemailehStanford UniversityVerified email at stanford.edu
Robert A. SaxtonAssistant Professor, UC BerkeleyVerified email at berkeley.edu
Elizaveta (Lisa) FreinkmanSenior R&D Project Manager, Locus BiosciencesVerified email at locus-bio.com
Richard PossematoAssociate Professor, NYU School of MedicineVerified email at nyulangone.org
Kuang ShenAssistant Professor, UMass Medical SchoolVerified email at umassmed.edu
David E. RootBroad InstituteVerified email at broadinstitute.org
Hediye Erdjument-BromageProteomics Core Manager, Memorial Sloan-Kettering Cancer Center, New York, NY, USAVerified email at ski.mskcc.org
Jason MoffatSenior Scientist & Program Head, Genetics & Genome Biology, Sickkids Hospital; Professor, UofTVerified email at utoronto.ca
Shomit SenguptaSenior Director, Atavistik BioVerified email at atavistikbio.com
Pekka KatajistoUniversity of Helsinki and Karolinska InstitutetVerified email at helsinki.fi
Peggy Ping HsuUniversity of MichiganVerified email at med.umich.edu
Omer YilmazMassachusetts Institute of TechnologyVerified email at mit.edu

David M. Sabatini

Institute of Organic Chemistry and Biochemistry of the CAS

Verified email at uochb.cas.cz

mTOR rapamycin growth nutrients metabolism lysosome leucine


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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹ DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021	12598*	2021
mTOR signaling in growth control and disease M Laplante, DM Sabatini cell 149 (2), 274-293, 2012	9036	2012
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex DD Sarbassov, DA Guertin, SM Ali, DM Sabatini Science 307 (5712), 1098-1101, 2005	8139	2005
mTOR signaling in growth, metabolism, and disease RA Saxton, DM Sabatini Cell 168 (6), 960-976, 2017	6604	2017
CellProfiler: image analysis software for identifying and quantifying cell phenotypes AE Carpenter, TR Jones, MR Lamprecht, C Clarke, IH Kang, O Friman, ... Genome biology 7, 1-11, 2006	5301	2006
mTOR: from growth signal integration to cancer, diabetes and ageing R Zoncu, A Efeyan, DM Sabatini Nature reviews Molecular cell biology 12 (1), 21-35, 2011	4577	2011
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery DH Kim, DD Sarbassov, SM Ali, JE King, RR Latek, ... Cell 110 (2), 163-175, 2002	3609	2002
Defining the role of mTOR in cancer DA Guertin, DM Sabatini Cancer cell 12 (1), 9-22, 2007	3462	2007
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton DD Sarbassov, SM Ali, DH Kim, DA Guertin, RR Latek, ... Current biology 14 (14), 1296-1302, 2004	3320	2004
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB DD Sarbassov, SM Ali, S Sengupta, JH Sheen, PP Hsu, AF Bagley, ... Molecular cell 22 (2), 159-168, 2006	3190	2006
Genetic screens in human cells using the CRISPR-Cas9 system T Wang, JJ Wei, DM Sabatini, ES Lander Science 343 (6166), 80-84, 2014	3118	2014
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 Y Sancak, TR Peterson, YD Shaul, RA Lindquist, CC Thoreen, ... Science 320 (5882), 1496-1501, 2008	2969	2008
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 DA Barbie, P Tamayo, JS Boehm, SY Kim, SE Moody, IF Dunn, ... Nature 462 (7269), 108-112, 2009	2866	2009
Cancer cell metabolism: Warburg and beyond PP Hsu, DM Sabatini Cell 134 (5), 703-707, 2008	2764	2008
mTOR signaling at a glance M Laplante, DM Sabatini Journal of cell science 122 (20), 3589-3594, 2009	2757	2009
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids Y Sancak, L Bar-Peled, R Zoncu, AL Markhard, S Nada, DM Sabatini Cell 141 (2), 290-303, 2010	2562	2010
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen J Moffat, DA Grueneberg, X Yang, SY Kim, AM Kloepfer, G Hinkle, ... Cell 124 (6), 1283-1298, 2006	1985	2006
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 CC Thoreen, SA Kang, JW Chang, Q Liu, J Zhang, Y Gao, LJ Reichling, ... Journal of Biological Chemistry 284 (12), 8023-8032, 2009	1978	2009
Growing roles for the mTOR pathway DD Sarbassov, SM Ali, DM Sabatini Current opinion in cell biology 17 (6), 596-603, 2005	1972	2005
RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs DM Sabatini, H Erdjument-Bromage, M Lui, P Tempst, SH Snyder Cell 78 (1), 35-43, 1994	1939	1994

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