David Orlando
David Orlando
Associate Director, Syros Pharmaceuticals
Verified email at syros.com
Title
Cited by
Cited by
Year
Master transcription factors and mediator establish super-enhancers at key cell identity genes
WA Whyte, DA Orlando, D Hnisz, BJ Abraham, CY Lin, MH Kagey, ...
Cell 153 (2), 307-319, 2013
21712013
Mediator and cohesin connect gene expression and chromatin architecture
MH Kagey, JJ Newman, S Bilodeau, Y Zhan, DA Orlando, NL van Berkum, ...
Nature 467 (7314), 430-435, 2010
16962010
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
J Lovén, HA Hoke, CY Lin, A Lau, DA Orlando, CR Vakoc, JE Bradner, ...
Cell 153 (2), 320-334, 2013
16422013
A high-resolution root spatiotemporal map reveals dominant expression patterns
SM Brady, DA Orlando, JY Lee, JY Wang, J Koch, JR Dinneny, D Mace, ...
Science 318 (5851), 801-806, 2007
9752007
Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling
AC Mullen, DA Orlando, JJ Newman, J Lovén, RM Kumar, S Bilodeau, ...
Cell 147 (3), 565-576, 2011
5272011
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation
WA Whyte, S Bilodeau, DA Orlando, HA Hoke, GM Frampton, CT Foster, ...
Nature 482 (7384), 221-225, 2012
4852012
Revisiting global gene expression analysis
J Lovén, DA Orlando, AA Sigova, CY Lin, PB Rahl, CB Burge, DL Levens, ...
Cell 151 (3), 476-482, 2012
4822012
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
CJ Ceol, Y Houvras, J Jane-Valbuena, S Bilodeau, DA Orlando, V Battisti, ...
Nature 471 (7339), 513-517, 2011
4262011
Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells
AA Sigova, AC Mullen, B Molinie, S Gupta, DA Orlando, MG Guenther, ...
Proceedings of the National Academy of Sciences 110 (8), 2876-2881, 2013
3852013
Global control of cell-cycle transcription by coupled CDK and network oscillators
DA Orlando, CY Lin, A Bernard, JY Wang, JES Socolar, ES Iversen, ...
Nature 453 (7197), 944-947, 2008
3072008
Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome
DA Orlando, MW Chen, VE Brown, S Solanki, YJ Choi, ER Olson, CC Fritz, ...
Cell reports 9 (3), 1163-1170, 2014
2512014
Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons
Y Li, H Wang, J Muffat, AW Cheng, DA Orlando, J Lovén, S Kwok, ...
Cell Stem Cell 13 (4), 446-458, 2013
2392013
Protonophore‐and pH‐insensitive glucose and sucrose accumulation detected by FRET nanosensors in Arabidopsis root tips
B Chaudhuri, F Hörmann, S Lalonde, SM Brady, DA Orlando, P Benfey, ...
The Plant Journal 56 (6), 948-962, 2008
952008
Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements
JM Dowen, S Bilodeau, DA Orlando, MR Hübner, BJ Abraham, ...
Stem cell reports 1 (5), 371-378, 2013
902013
Cyclin-Dependent Kinases Are Regulators and Effectors of Oscillations Driven by a Transcription Factor Network
LAS Kovacs, MB Mayhew, DA Orlando, Y Jin, Q Li, C Huang, SI Reed, ...
Molecular Cell 49 (6), 1177-1179, 2013
562013
Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network
LAS Kovacs, MB Mayhew, DA Orlando, Y Jin, Q Li, C Huang, SI Reed, ...
Molecular cell 45 (5), 669-679, 2012
562012
Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network
LAS Kovacs, MB Mayhew, DA Orlando, Y Jin, Q Li, C Huang, SI Reed, ...
Molecular cell 45 (5), 669-679, 2012
562012
Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network
LAS Kovacs, MB Mayhew, DA Orlando, Y Jin, Q Li, C Huang, SI Reed, ...
Molecular cell 45 (5), 669-679, 2012
562012
Superenhancer analysis defines novel epigenomic subtypes of non-APL AML, including an RARα dependency targetable by SY-1425, a potent and selective RARα agonist
MR McKeown, MR Corces, ML Eaton, C Fiore, E Lee, JT Lopez, ...
Cancer discovery, 2017
492017
Manipulating large-scale Arabidopsis microarray expression data: identifying dominant expression patterns and biological process enrichment
DA Orlando, SM Brady, JD Koch, JR Dinneny, PN Benfey
Plant Systems Biology, 57-77, 2009
462009
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