Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis S Bardarov, S Bardarov Jr, MS Pavelka Jr, V Sambandamurthy, M Larsen, ... Microbiology 148 (10), 3007-3017, 2002 | 717 | 2002 |
A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis VK Sambandamurthy, X Wang, B Chen, RG Russell, S Derrick, FM Collins, ... Nature medicine 8 (10), 1171-1174, 2002 | 443 | 2002 |
Survival perspectives from the world's most successful pathogen, Mycobacterium tuberculosis SM Hingley-Wilson, VK Sambandamurthy, WR Jacobs Jr Nature immunology 4 (10), 949-955, 2003 | 266 | 2003 |
Mycobacterium tuberculosis ΔRD1 ΔpanCD: a safe and limited replicating mutant strain that protects immunocompetent and immunocompromised mice against experimental tuberculosis VK Sambandamurthy, SC Derrick, T Hsu, B Chen, MH Larsen, ... Vaccine 24 (37-39), 6309-6320, 2006 | 222 | 2006 |
The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease EK Schmitt, M Riwanto, V Sambandamurthy, S Roggo, C Miault, ... Angewandte Chemie International Edition 26 (50), 5889-5891, 2011 | 206 | 2011 |
Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis VK Sambandamurthy, SC Derrick, KV Jalapathy, B Chen, RG Russell, ... Infection and immunity 73 (2), 1196-1203, 2005 | 177 | 2005 |
Protection Elicited by a Double Leucine and Pantothenate Auxotroph of Mycobacterium tuberculosis in Guinea Pigs SL Sampson, CC Dascher, VK Sambandamurthy, RG Russell, ... Infection and immunity 72 (5), 3031-3037, 2004 | 171 | 2004 |
Azaindoles: Noncovalent DprE1 Inhibitors from Scaffold Morphing Efforts, Kill Mycobacterium tuberculosis and Are Efficacious in Vivo PS Shirude, R Shandil, C Sadler, M Naik, V Hosagrahara, S Hameed, ... Journal of Medicinal Chemistry 56 (23), 9701-9708, 2013 | 161 | 2013 |
Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates MH Larsen, K Biermann, B Chen, T Hsu, VK Sambandamurthy, ... Vaccine 27 (34), 4709-4717, 2009 | 123 | 2009 |
Bactericidal activity and mechanism of action of AZD5847, a novel oxazolidinone for treatment of tuberculosis V Balasubramanian, S Solapure, H Iyer, A Ghosh, S Sharma, P Kaur, ... Antimicrobial agents and chemotherapy 58 (1), 495-502, 2014 | 120 | 2014 |
Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis M Kurabachew, SHJ Lu, P Krastel, EK Schmitt, BL Suresh, A Goh, ... Journal of antimicrobial chemotherapy 62 (4), 713-719, 2008 | 115 | 2008 |
Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis SJ Tantry, SD Markad, V Shinde, J Bhat, G Balakrishnan, AK Gupta, ... Journal of medicinal chemistry 60 (4), 1379-1399, 2017 | 111 | 2017 |
Methyl-thiazoles: a novel mode of inhibition with the potential to develop novel inhibitors targeting InhA in Mycobacterium tuberculosis PS Shirude, P Madhavapeddi, M Naik, K Murugan, V Shinde, ... Journal of Medicinal Chemistry 56 (21), 8533-8542, 2013 | 106 | 2013 |
Multi-scale surface topography to minimize adherence and viability of nosocomial drug-resistant bacteria J Hasan, S Jain, R Padmarajan, S Purighalla, VK Sambandamurthy, ... Materials & design 140, 332-344, 2018 | 100 | 2018 |
Discovery of pyrazolopyridones as a novel class of noncovalent DprE1 inhibitor with potent anti-mycobacterial activity M Panda, S Ramachandran, V Ramachandran, PS Shirude, ... Journal of medicinal chemistry 57 (11), 4761-4771, 2014 | 99 | 2014 |
4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity M Naik, V Humnabadkar, SJ Tantry, M Panda, A Narayan, S Guptha, ... Journal of medicinal chemistry 57 (12), 5419-5434, 2014 | 95 | 2014 |
Lead optimization of 1, 4-azaindoles as antimycobacterial agents PS Shirude, RK Shandil, MR Manjunatha, C Sadler, M Panda, V Panduga, ... Journal of medicinal chemistry 57 (13), 5728-5737, 2014 | 94 | 2014 |
Aminopyrazinamides: Novel and Specific GyrB Inhibitors that Kill Replicating and Nonreplicating Mycobacterium tuberculosis PS Shirude, P Madhavapeddi, JA Tucker, K Murugan, V Patil, ... ACS chemical biology 8 (3), 519-523, 2013 | 90 | 2013 |
Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis VK Sambandamurthy, WR Jacobs Jr Microbes and infection 7 (5-6), 955-961, 2005 | 82 | 2005 |
In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis M Zhang, C Sala, N Dhar, A Vocat, VK Sambandamurthy, S Sharma, ... Antimicrobial agents and chemotherapy 58 (6), 3217-3223, 2014 | 71 | 2014 |