Ari Firestone
Ari Firestone
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Cited by
Cited by
Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions
K Ling, RL Doughman, AJ Firestone, MW Bunce, RA Anderson
Nature 420 (6911), 89-93, 2002
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
AJ Firestone, JS Weinger, M Maldonado, K Barlan, LD Langston, ...
Nature 484 (7392), 125-129, 2012
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
JM Hyman, AJ Firestone, VM Heine, Y Zhao, CA Ocasio, K Han, M Sun, ...
Proceedings of the National Academy of Sciences 106 (33), 14132-14137, 2009
Phosphatidylinositol Phosphate Kinases Put PI4,5P2 in Its Place
RL Doughman, AJ Firestone, RA Anderson
The Journal of membrane biology 194, 77-89, 2003
Tyrosine phosphorylation of type Iγ phosphatidylinositol phosphate kinase by Src regulates an integrin–talin switch
K Ling, RL Doughman, VV Iyer, AJ Firestone, SF Bairstow, DF Mosher, ...
The Journal of cell biology 163 (6), 1339-1349, 2003
KRAS allelic imbalance enhances fitness and modulates MAP kinase dependence in cancer
MR Burgess, E Hwang, R Mroue, CM Bielski, AM Wandler, BJ Huang, ...
Cell 168 (5), 817-829. e15, 2017
Membrane ruffling requires coordination between type Iα phosphatidylinositol phosphate kinase and Rac signaling
RL Doughman, AJ Firestone, ML Wojtasiak, MW Bunce, RA Anderson
Journal of biological chemistry 278 (25), 23036-23045, 2003
Type Iγ661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis
SF Bairstow, K Ling, X Su, AJ Firestone, C Carbonara, RA Anderson
Journal of Biological Chemistry 281 (29), 20632-20642, 2006
Preclinical efficacy of MEK inhibition in Nras-mutant AML
MR Burgess, E Hwang, AJ Firestone, T Huang, J Xu, J Zuber, N Bohin, ...
Blood, The Journal of the American Society of Hematology 124 (26), 3947-3955, 2014
Controlling destiny through chemistry: small-molecule regulators of cell fate
AJ Firestone, JK Chen
ACS chemical biology 5 (1), 15-34, 2010
Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation
J Xu, KM Haigis, AJ Firestone, ME McNerney, Q Li, E Davis, SC Chen, ...
Cancer discovery 3 (9), 993-1001, 2013
Synthetic lethal interaction of SHOC2 depletion with MEK inhibition in RAS-driven cancers
R Sulahian, JJ Kwon, KH Walsh, E Pailler, TL Bosse, M Thaker, ...
Cell reports 29 (1), 118-134. e8, 2019
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance
MF Pech, LE Fong, JE Villalta, LJG Chan, S Kharbanda, JJ O'Brien, ...
Elife 8, e47362, 2019
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
JR Remsberg, RM Suciu, NA Zambetti, TW Hanigan, AJ Firestone, ...
Nature chemical biology 17 (8), 856-864, 2021
KRAS engages AGO2 to enhance cellular transformation
S Shankar, S Pitchiaya, R Malik, V Kothari, Y Hosono, AK Yocum, ...
Cell reports 14 (6), 1448-1461, 2016
Arhgap36-dependent activation of Gli transcription factors
PG Rack, J Ni, AY Payumo, V Nguyen, JA Crapster, V Hovestadt, M Kool, ...
Proceedings of the National Academy of Sciences 111 (30), 11061-11066, 2014
The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling
T Cupido, PG Rack, AJ Firestone, JM Hyman, K Han, S Sinha, CA Ocasio, ...
Angewandte Chemie 121 (13), 2357-2360, 2009
Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent
JK Mich, H Blaser, NA Thomas, AJ Firestone, D Yelon, E Raz, JK Chen
Developmental biology 328 (2), 342-354, 2009
Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice
R Mroue, B Huang, S Braunstein, AJ Firestone, JL Nakamura
PLoS genetics 11 (5), e1005235, 2015
KRAS insertion mutations are oncogenic and exhibit distinct functional properties
Y White, A Bagchi, J Van Ziffle, A Inguva, G Bollag, C Zhang, H Carias, ...
Nature communications 7 (1), 10647, 2016
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