| Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions K Ling, RL Doughman, AJ Firestone, MW Bunce, RA Anderson Nature 420 (6911), 89-93, 2002 | 545 | 2002 |
| Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein AJ Firestone, JS Weinger, M Maldonado, K Barlan, LD Langston, ... Nature 484 (7392), 125-129, 2012 | 405 | 2012 |
| Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade JM Hyman, AJ Firestone, VM Heine, Y Zhao, CA Ocasio, K Han, M Sun, ... Proceedings of the National Academy of Sciences 106 (33), 14132-14137, 2009 | 355 | 2009 |
| Phosphatidylinositol Phosphate Kinases Put PI4,5P2 in Its Place RL Doughman, AJ Firestone, RA Anderson The Journal of membrane biology 194, 77-89, 2003 | 320 | 2003 |
| Tyrosine phosphorylation of type Iγ phosphatidylinositol phosphate kinase by Src regulates an integrin–talin switch K Ling, RL Doughman, VV Iyer, AJ Firestone, SF Bairstow, DF Mosher, ... The Journal of cell biology 163 (6), 1339-1349, 2003 | 182 | 2003 |
| KRAS allelic imbalance enhances fitness and modulates MAP kinase dependence in cancer MR Burgess, E Hwang, R Mroue, CM Bielski, AM Wandler, BJ Huang, ... Cell 168 (5), 817-829. e15, 2017 | 180 | 2017 |
| Membrane ruffling requires coordination between type Iα phosphatidylinositol phosphate kinase and Rac signaling RL Doughman, AJ Firestone, ML Wojtasiak, MW Bunce, RA Anderson Journal of biological chemistry 278 (25), 23036-23045, 2003 | 152 | 2003 |
| Type Iγ661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis SF Bairstow, K Ling, X Su, AJ Firestone, C Carbonara, RA Anderson Journal of Biological Chemistry 281 (29), 20632-20642, 2006 | 109 | 2006 |
| Preclinical efficacy of MEK inhibition in Nras-mutant AML MR Burgess, E Hwang, AJ Firestone, T Huang, J Xu, J Zuber, N Bohin, ... Blood, The Journal of the American Society of Hematology 124 (26), 3947-3955, 2014 | 96 | 2014 |
| Controlling destiny through chemistry: small-molecule regulators of cell fate AJ Firestone, JK Chen ACS chemical biology 5 (1), 15-34, 2010 | 91 | 2010 |
| Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance MF Pech, LE Fong, JE Villalta, LJG Chan, S Kharbanda, JJ O'Brien, ... Elife 8, e47362, 2019 | 79 | 2019 |
| Synthetic lethal interaction of SHOC2 depletion with MEK inhibition in RAS-driven cancers R Sulahian, JJ Kwon, KH Walsh, E Pailler, TL Bosse, M Thaker, ... Cell reports 29 (1), 118-134. e8, 2019 | 75 | 2019 |
| Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation J Xu, KM Haigis, AJ Firestone, ME McNerney, Q Li, E Davis, SC Chen, ... Cancer discovery 3 (9), 993-1001, 2013 | 70 | 2013 |
| ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth JR Remsberg, RM Suciu, NA Zambetti, TW Hanigan, AJ Firestone, ... Nature chemical biology 17 (8), 856-864, 2021 | 55 | 2021 |
| KRAS engages AGO2 to enhance cellular transformation S Shankar, S Pitchiaya, R Malik, V Kothari, Y Hosono, AK Yocum, ... Cell reports 14 (6), 1448-1461, 2016 | 47 | 2016 |
| Arhgap36-dependent activation of Gli transcription factors PG Rack, J Ni, AY Payumo, V Nguyen, JA Crapster, V Hovestadt, M Kool, ... Proceedings of the National Academy of Sciences 111 (30), 11061-11066, 2014 | 45 | 2014 |
| The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling T Cupido, PG Rack, AJ Firestone, JM Hyman, K Han, S Sinha, CA Ocasio, ... Angewandte Chemie 121 (13), 2357-2360, 2009 | 45 | 2009 |
| Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent JK Mich, H Blaser, NA Thomas, AJ Firestone, D Yelon, E Raz, JK Chen Developmental biology 328 (2), 342-354, 2009 | 25 | 2009 |
| KRAS insertion mutations are oncogenic and exhibit distinct functional properties Y White, A Bagchi, J Van Ziffle, A Inguva, G Bollag, C Zhang, H Carias, ... Nature communications 7 (1), 10647, 2016 | 20 | 2016 |
| Discovery of a potent chloroacetamide GPX4 inhibitor with bioavailability to enable target engagement in mice, a potential tool compound for inducing ferroptosis in vivo JT Randolph, MJ O’Connor, F Han, CW Hutchins, YA Siu, M Cho, ... Journal of Medicinal Chemistry 66 (6), 3852-3865, 2023 | 19 | 2023 |
