Gerald I Shulman
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Cellular mechanisms of insulin resistance
GI Shulman
The Journal of clinical investigation 106 (2), 171-176, 2000
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
KF Petersen, S Dufour, D Befroy, R Garcia, GI Shulman
New England Journal of Medicine 350 (7), 664-671, 2004
Mitochondrial dysfunction and type 2 diabetes
BB Lowell, GI Shulman
Science 307 (5708), 384-387, 2005
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
KF Petersen, D Befroy, S Dufour, J Dziura, C Ariyan, DL Rothman, ...
Science 300 (5622), 1140-1142, 2003
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
H Cho, J Mu, JK Kim, JL Thorvaldsen, Q Chu, EB Crenshaw, KH Kaestner, ...
Science 292 (5522), 1728-1731, 2001
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
J Henao-Mejia, E Elinav, C Jin, L Hao, WZ Mehal, T Strowig, CA Thaiss, ...
Nature 482 (7384), 179-185, 2012
Mechanisms for insulin resistance: common threads and missing links
VT Samuel, GI Shulman
Cell 148 (5), 852-871, 2012
Disruption of IRS-2 causes type 2 diabetes in mice
DJ Withers, JS Gutierrez, H Towery, DJ Burks, JM Ren, S Previs, Y Zhang, ...
Nature 391 (6670), 900-904, 1998
Mechanism of free fatty acid-induced insulin resistance in humans
M Roden, TB Price, G Perseghin, KF Petersen, DL Rothman, GW Cline, ...
The Journal of clinical investigation 97 (12), 2859-2865, 1996
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
C Yu, Y Chen, GW Cline, D Zhang, H Zong, Y Wang, R Bergeron, JK Kim, ...
Journal of Biological Chemistry 277 (52), 50230-50236, 2002
Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β‐cell dysfunction
G Boden, GI Shulman
European journal of clinical investigation 32, 14-23, 2002
Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity
A Dresner, D Laurent, M Marcucci, ME Griffin, S Dufour, GW Cline, ...
The Journal of clinical investigation 103 (2), 253-259, 1999
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
ME Griffin, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee, LJ Goodyear, ...
Diabetes 48 (6), 1270-1274, 1999
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
VT Samuel, ZX Liu, X Qu, BD Elder, S Bilz, D Befroy, AJ Romanelli, ...
Journal of Biological Chemistry 279 (31), 32345-32353, 2004
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study
M Krssak, KF Petersen, A Dresner, L DiPietro, SM Vogel, DL Rothman, ...
Diabetologia 42 (1), 113-116, 1999
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
LD Klaman, O Boss, OD Peroni, JK Kim, JL Martino, JM Zabolotny, ...
Molecular and cellular biology 20 (15), 5479-5489, 2000
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
ED Abel, O Peroni, JK Kim, YB Kim, O Boss, E Hadro, T Minnemann, ...
Nature 409 (6821), 729-733, 2001
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
GI Shulman, DL Rothman, T Jue, P Stein, RA DeFronzo, RG Shulman
New England Journal of Medicine 322 (4), 223-228, 1990
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
MD Michael, RN Kulkarni, C Postic, SF Previs, GI Shulman, ...
Molecular cell 6 (1), 87-97, 2000
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
JY Kim, E Van De Wall, M Laplante, A Azzara, ME Trujillo, SM Hofmann, ...
The Journal of clinical investigation 117 (9), 2621-2637, 2007
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