Wai Leong Tam
Wai Leong Tam
Genome Institute of Singapore
Verified email at - Homepage
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A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes
KC Miranda, T Huynh, Y Tay, YS Ang, WL Tam, AM Thomson, B Lim, ...
Cell 126 (6), 1203-1217, 2006
The epigenetics of epithelial-mesenchymal plasticity in cancer
WL Tam, RA Weinberg
Nature medicine 19 (11), 1438-1449, 2013
Slug and Sox9 cooperatively determine the mammary stem cell state
W Guo, Z Keckesova, JL Donaher, T Shibue, V Tischler, F Reinhardt, ...
Cell 148 (5), 1015-1028, 2012
Reciprocal Transcriptional Regulation of Pou5f1 and Sox2 via the Oct4/Sox2 Complex in Embryonic Stem Cells
JL Chew, YH Loh, W Zhang, X Chen, WL Tam, LS Yeap, P Li, YS Ang, ...
Molecular and cellular biology 25 (14), 6031-6046, 2005
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
X Chen, D Iliopoulos, Q Zhang, Q Tang, MB Greenblatt, M Hatziapostolou, ...
Nature 508 (7494), 103-107, 2014
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells
X Ye, WL Tam, T Shibue, Y Kaygusuz, F Reinhardt, E Ng Eaton, ...
Nature 525 (7568), 256-260, 2015
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1
J Zhang, WL Tam, GQ Tong, Q Wu, HY Chan, BS Soh, Y Lou, J Yang, ...
Nature cell biology 8 (10), 1114-1123, 2006
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
H Lu, KR Clauser, WL Tam, J Fröse, X Ye, EN Eaton, F Reinhardt, ...
Nature cell biology 16 (11), 1105-1117, 2014
Tbx3 improves the germ-line competency of induced pluripotent stem cells
J Han, P Yuan, H Yang, J Zhang, BS Soh, P Li, SL Lim, S Cao, J Tay, ...
Nature 463 (7284), 1096-1100, 2010
Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells
WL Tam, H Lu, J Buikhuisen, BS Soh, E Lim, F Reinhardt, ZJ Wu, JA Krall, ...
Cancer cell 24 (3), 347-364, 2013
Genomic landscape of lung adenocarcinoma in East Asians
J Chen, H Yang, ASM Teo, LB Amer, FG Sherbaf, CQ Tan, JJS Alvarez, ...
Nature genetics 52 (2), 177-186, 2020
Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability
DR Pattabiraman, B Bierie, KI Kober, P Thiru, JA Krall, C Zill, F Reinhardt, ...
Science 351 (6277), aad3680, 2016
MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1
YMS Tay, WL Tam, YS Ang, PM Gaughwin, H Yang, W Wang, R Liu, ...
Stem cells 26 (1), 17-29, 2008
Methionine is a metabolic dependency of tumor-initiating cells
Z Wang, LY Yip, JHJ Lee, Z Wu, HY Chew, PKW Chong, CC Teo, ...
Nature medicine 25 (5), 825-837, 2019
Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages
CY Lim, WL Tam, J Zhang, HS Ang, H Jia, L Lipovich, HH Ng, CL Wei, ...
Cell stem cell 3 (5), 543-554, 2008
The transcriptome of human oocytes
AM Kocabas, J Crosby, PJ Ross, HH Otu, Z Beyhan, H Can, WL Tam, ...
Proceedings of the National Academy of Sciences 103 (38), 14027-14032, 2006
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition
YD Shaul, E Freinkman, WC Comb, JR Cantor, WL Tam, P Thiru, D Kim, ...
Cell 158 (5), 1094-1109, 2014
T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways
WL Tam, CY Lim, J Han, J Zhang, YS Ang, HH Ng, H Yang, B Lim
Stem cells 26 (8), 2019-2031, 2008
Novel therapeutic targets on the horizon for lung cancer
WL Tan, A Jain, A Takano, EW Newell, NG Iyer, WT Lim, EH Tan, W Zhai, ...
The Lancet Oncology 17 (8), e347-e362, 2016
Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression
WC Zhang, TM Chin, H Yang, ME Nga, DP Lunny, EKH Lim, LL Sun, ...
Nature communications 7 (1), 11702, 2016
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